MLK
Le MLK (Mixed-Lineage Kinases) sono un gruppo di chinasi in grado di attivare più vie MAPK, tra cui JNK e p38, fosforilando le chinasi MAP a monte (MAP2K). Le MLK sono coinvolte nelle risposte cellulari allo stress, nell'apoptosi e nella neuroinfiammazione. La disregolazione dell'attività delle MLK è associata a malattie neurodegenerative e a certi tipi di cancro. Presso CymitQuimica, offriamo una gamma di modulatori MLK di alta qualità per supportare la tua ricerca in neurobiologia, risposta allo stress e trasduzione del segnale.
Trovati 20 prodotti di "MLK"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
GW806742X
CAS:GW806742X inhibits MLKL with Kd 9.3 μM, preventing necroptosis; also targets VEGFR2.Formula:C25H22F3N7O4SPurezza:98.3%Colore e forma:SolidPeso molecolare:573.55Anticancer agent 267
Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.Formula:C13H11N5O4SColore e forma:SolidPeso molecolare:333.32PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.Formula:C46H55F2N9O9SColore e forma:SolidPeso molecolare:948.05MLKL-IN-2
CAS:MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.
Formula:C26H25N5OPurezza:98.30%Colore e forma:SolidPeso molecolare:423.51KWCN-41
CAS:KWCN-41, a RIPK1 inhibitor with 88 nM IC50, blocks necrosis, spares apoptosis, and is anti-inflammatory.Formula:C18H17N3O2Colore e forma:SolidPeso molecolare:307.35MLKL-IN-7
MLKL-IN-7 (compound 9) is an MLKL inhibitor that exhibits anti-necrotic activity in HT-29 cells, with an IC50 value of 148.4 nM.Formula:C21H15N5O5S2Peso molecolare:481.05146NecroX-2
CAS:NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.Formula:C25H32N4O4S2Purezza:97.12%Colore e forma:SolidPeso molecolare:516.68RIPK3-IN-3
RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.Formula:C16H11N5SColore e forma:SolidPeso molecolare:305.36PROTAC MLKL Degrader-2
PROTAC MLKL Degrader-2, a PROTAC that targets MLKL (Mixed Lineage Kinase), incorporates the PROTAC target protein ligand, E3 ligase ligand Thalidomide, and PROTAC Linker N-Methylpiperazine. The conjugate of the E3 ubiquitin ligase ligand and Linker is Thalidomide-N-Methylpiperazine. This compound exhibits antinecroptotic activity in human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model.Formula:C36H35N9O9SColore e forma:SolidPeso molecolare:769.78CEP1347-VHL-02
CEP1347-VHL-02 is a PROTAC that selectively targets MLK3. This compound is composed of the target protein ligand CEP-1347, the E3 ubiquitin ligase ligand (S,R,S)-AHPC-Me, and the PROTAC linker Amino-PEG3-CH2COOH. The participating component responsible for controlling the target protein ligand activity is CEP-1347-acid, whereas the conjugate of the E3 ubiquitin ligase ligand and linker is identified as (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2.Formula:C61H72N8O11S3Colore e forma:SolidPeso molecolare:1189.47MLK-IN-1
CAS:MLK-IN-1 is a potent and selective mixed-lineage kinase 3 (MLK-3) inhibitor, showing excellent brain penetration and high specificity for MLK-3. MLK-IN-1 at 100 nM supports sustained axonogenesis in cultures challenged with HIV-1 Tat-activated microglia and protects neuronal cells from Tat-induced damage, establishing it as a valuable probe for neuroinflammation and neurodegeneration research.Formula:C23H20N4O3SPurezza:99.74%Colore e forma:SolidPeso molecolare:432.5Ref: TM-T39102
1mg54,00€5mg114,00€10mg178,00€25mg394,00€50mg620,00€100mg982,00€1mL*10mM (DMSO)126,00€Necrosulfonamide
CAS:Necrosulfonamide ((E)-Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. High-Quality, Low-Cost!Formula:C18H15N5O6S2Purezza:98.85% - 99.49%Colore e forma:SolidPeso molecolare:461.47MLKL-IN-5
CAS:MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .Formula:C18H20N6O4SColore e forma:SolidPeso molecolare:416.45SZM-1209
CAS:SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM.Formula:C31H29F5N4O5S2Purezza:98%Colore e forma:SolidPeso molecolare:696.71IM-54
CAS:IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.Formula:C19H23N3O2Purezza:99.24%Colore e forma:SolidPeso molecolare:325.4Ref: TM-T24160
1mg49,00€5mg104,00€10mg164,00€25mg281,00€50mg404,00€100mg567,00€1mL*10mM (DMSO)115,00€TC13172
CAS:TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.Formula:C17H16N4O5SPurezza:98%Colore e forma:SolidPeso molecolare:388.4MLKL-IN-1
MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM.Formula:C19H20N2O3Colore e forma:SolidPeso molecolare:324.37MLKL-IN-6
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.
Formula:C20H18N4O5Purezza:98%Colore e forma:SolidPeso molecolare:394.38Topoisomerase I/II inhibitor 8
CAS:TopoisomeraseI/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of TopoisomeraseI/II that induces DNA damage and activates PARP-1, leading to the activation of RIPK1, RIPK3, and MLKL, ultimately causing necroptosis. It shows significant anticancer activity by effectively targeting cancer cell nuclei and inducing cell death through necroptosis, offering substantial clinical potential in overcoming resistance in cancer treatment.Formula:C14H11Br2NO5S2Colore e forma:SolidPeso molecolare:497.179MBA-m1
CAS:MBA-m1 is an MLKL inhibitor that suppresses necroptosis in Mlkl−/−NIH-3T3 cells. Additionally, MBA-m1 alleviates disease conditions in mouse models of dermatitis and abdominal aortic aneurysm induced by MLKL.Formula:C27H21ClN2O2Colore e forma:SolidPeso molecolare:440.92
