Ras
Le proteine Ras sono piccole GTPasi che agiscono come interruttori molecolari nella via di segnalazione MAPK, controllando la crescita, la differenziazione e la sopravvivenza cellulare. Ras attivato avvia una cascata di segnalazione che include Raf, MEK ed ERK, portando a varie risposte cellulari. Le mutazioni nei geni Ras sono comuni nei tumori, rendendo Ras un importante focus della ricerca sul cancro. Presso CymitQuimica, offriamo una gamma di modulatori di Ras per supportare la tua ricerca in biologia del cancro, trasduzione del segnale e sviluppo terapeutico.
Trovati 156 prodotti di "Ras"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
HJC0197
CAS:HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Formula:C19H21N3OSPurezza:98.05%Colore e forma:SolidPeso molecolare:339.45ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formula:C21H17ClF2N4O2Purezza:97.78%Colore e forma:SolidPeso molecolare:430.84MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formula:C22H18N4Purezza:98.07% - 99.52%Colore e forma:SolidPeso molecolare:338.41Ketoconazole
CAS:<p>Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.</p>Formula:C26H28Cl2N4O4Purezza:99.53% - 99.62%Colore e forma:Crystals From 4-Methylpentanone SolidPeso molecolare:531.43K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Formula:C31H33ClN4O4Purezza:99.00%Colore e forma:SolidPeso molecolare:561.07MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formula:C33H39N7O2Purezza:97.3% - 99.07%Colore e forma:SolidPeso molecolare:565.71BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formula:C23H25F3N4O3Purezza:99.2% - 99.66%Colore e forma:SolidPeso molecolare:462.46RMC-6236
CAS:<p>RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.</p>Formula:C44H58N8O5SPurezza:98.24% - 99.92%Colore e forma:SolidPeso molecolare:811.05KRAS inhibitor-42
<p>KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.</p>Formula:C34H47ClN8O4S2Colore e forma:SolidPeso molecolare:730.28502pan-KRAS-IN-10
Pan-KRAS-IN-10 (Compound 58) acts as an inhibitor of the human tumor mutant gene KRAS. It suppresses the proliferation of KRAS mutant cells, specifically AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.7 and 0.24 nM, respectively.Formula:C45H57N7O5SPeso molecolare:807.41419KRAS G12D inhibitor 20
KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.Formula:C18H26N6OPeso molecolare:342.21681KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Formula:C31H30F5N7O2Purezza:98%Colore e forma:SolidPeso molecolare:627.61ADT-007
CAS:<p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>Formula:C26H24FNO5Purezza:97.75%Colore e forma:SoildPeso molecolare:449.47KRpep-2d
CAS:KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Formula:C109H183N43O25S2Colore e forma:SolidPeso molecolare:2560.02KRASG12C IN-14
<p>KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.</p>Formula:C51H65F4N9O9S2Colore e forma:SolidPeso molecolare:1088.24Rapaprutug
CAS:<p>Rapaprutug is a monoclonal antibody that targets human KARS1 (lysyl-tRNA synthetase 1). It can block inflammation-related signaling pathways involving KARS1, thereby reducing the production and release of inflammatory factors. Rapaprutug shows potential for research into inflammatory diseases.</p>Colore e forma:LiquidMRTF-A-IN-2
<p>MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Colore e forma:Odour SolidSOS1-IN-11
CAS:<p>SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).</p>Formula:C22H24F3N5OPurezza:99.4%Colore e forma:SolidPeso molecolare:431.45KRpep-2d TFA
<p>KRpep-2d (TFA) is a potent inhibitor of K-Ras, effectively hindering the proliferation of K-Ras-driven cancer cells, thereby serving as a valuable asset for</p>Formula:C110H183F3N44O27S2Colore e forma:SolidPeso molecolare:2675.03(E/Z)-ZINC09659342
CAS:<p>(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.</p>Formula:C23H15F3N2O4Purezza:>99.99%Colore e forma:SolidPeso molecolare:440.37Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Formula:C13H11F3N2OSColore e forma:SolidPeso molecolare:300.3Rac1 Inhibitor W56
CAS:Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Formula:C74H117N19O23SPurezza:98%Colore e forma:SolidPeso molecolare:1671.93Ras Inhibitory Peptide acetate
<p>Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.</p>Formula:C55H95N19O13Purezza:96.63%Colore e forma:SolidPeso molecolare:1230.46G12 TFA
G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.Formula:C54H96F3N15O17Peso molecolare:1283.70607KRAS inhibitor-33
KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.Formula:C33H39ClF2N6O3Colore e forma:SolidPeso molecolare:641.15FAM49B (190-198) mouse
CAS:<p>FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.</p>Formula:C49H71N9O14SColore e forma:SolidPeso molecolare:1042.2Pan-RAS-IN-7
CAS:Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.Formula:C59H76N8O8Colore e forma:SolidPeso molecolare:1025.28Goralatide
CAS:Goralatide, isolated from fetal calf bone marrow, exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells.Formula:C20H33N5O9Purezza:98%Colore e forma:SolidPeso molecolare:487.5MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Colore e forma:Odour SolidMC 976
CAS:MC 976 is a derivative of Vitamin D3.Formula:C27H42O3Purezza:98%Colore e forma:SolidPeso molecolare:414.63BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formula:C47H62N8O4SColore e forma:SolidPeso molecolare:835.11KS-58
CAS:KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.Formula:C64H89FN12O14S2Colore e forma:SolidPeso molecolare:1333.59GGTI298 Trifluoroacetate
CAS:<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Formula:C27H33N3O3S·C2HF3O2Purezza:98.07% - >99.99%Colore e forma:SolidPeso molecolare:593.66KRAS inhibitor-38
CAS:KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Formula:C53H68ClF2N9O8SColore e forma:SolidPeso molecolare:1064.686-Thio-GTP tetrasodium
6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.Formula:C10H12N5Na4O13P3SColore e forma:SolidPeso molecolare:626.89559MRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Formula:C22H21N3Colore e forma:SolidPeso molecolare:327.42SEPT9-IN-1
SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC50 value of 94.83 μM. It exhibits cytotoxicity against human oral squamous carcinoma cells, with an IC50 of 21 µM.Formula:C26H30ClN3O3Colore e forma:SolidPeso molecolare:467.988Sevelamer Carbonate
CAS:<p>Sevelamer carbonate, a non-absorbed polymer, binds phosphate with carbonate instead of chloride.</p>Formula:(C3H7N·C3H5ClO)x·xCH2O3Purezza:98%Colore e forma:SolidPeso molecolare:211.64Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Formula:C23H24ClN3O3Purezza:97.98%Colore e forma:SolidPeso molecolare:425.91K-Ras(G12C) inhibitor 12
CAS:K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C15H17ClIN3O3Purezza:97.16%Colore e forma:SolidPeso molecolare:449.67MLS000532223
CAS:<p>MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).</p>Formula:C15H9NO3Purezza:98.6%Colore e forma:SolidPeso molecolare:251.24(S)-AMG-510
CAS:<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Formula:C30H30F2N6O3Purezza:99.05% - 99.76%Colore e forma:SolidPeso molecolare:560.594CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formula:C21H17ClF6N2O2Purezza:99.58%Colore e forma:SolidPeso molecolare:478.82Adagrasib
CAS:<p>View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.</p>Formula:C32H35ClFN7O2Purezza:99.10% - 99.9%Colore e forma:SolidPeso molecolare:604.12FTI-277 hydrochloride
CAS:FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.Formula:C22H30ClN3O3S2Purezza:97.57% - 97.61%Colore e forma:SolidPeso molecolare:484.07ML-097
CAS:ML-097 (CID-2160985) is a pan activator of Ras-related GTPasesFormula:C14H11BrO3Purezza:99.12%Colore e forma:SolidPeso molecolare:307.139ARS-1620
CAS:<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Formula:C21H17ClF2N4O2Purezza:98.86%Colore e forma:SolidPeso molecolare:430.84ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Formula:C21H31N5O2Purezza:99.56%Colore e forma:SolidPeso molecolare:385.5SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Formula:C24H28N2O9SPurezza:95.65%Colore e forma:SolidPeso molecolare:520.55APS6-45
CAS:<p>APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.</p>Formula:C23H16F8N4O3Purezza:99.39%Colore e forma:SolidPeso molecolare:548.39
