ERK
ERK è una proteina chiave nella via di segnalazione MAPK (Mitogen-Activated Protein Kinase), coinvolta nella trasmissione dei segnali dai recettori di superficie cellulare al DNA nel nucleo della cellula. ERK svolge un ruolo cruciale nella regolazione di vari processi cellulari, tra cui la proliferazione, la differenziazione e la sopravvivenza. La disregolazione della segnalazione ERK è associata allo sviluppo del cancro e di altre malattie, rendendola un importante bersaglio per l'intervento terapeutico. Presso CymitQuimica, offriamo una selezione di inibitori e modulatori di ERK di alta qualità per supportare la tua ricerca sulla segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 204 prodotti di "ERK"
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ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Formula:C14H17ClN2O3SPurezza:98.92% - 99.84%Colore e forma:SolidPeso molecolare:328.814Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFormula:C21H23Cl3N4O2Purezza:99.85%Colore e forma:SolidPeso molecolare:469.79PERK-IN-3
CAS:PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).Formula:C22H16F2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:406.38CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Formula:C22H17Cl2FN4O2Colore e forma:SolidPeso molecolare:459.3BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formula:C16H14N2O3Purezza:98%Colore e forma:SolidPeso molecolare:282.29Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurezza:98.31%Colore e forma:SolidPeso molecolare:454.53Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Formula:C13H10BrNOColore e forma:SolidPeso molecolare:276.13ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Formula:C24H23Cl2FN4O2Colore e forma:SolidPeso molecolare:489.37ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Formula:C22H18Cl2N4O2S2Colore e forma:SolidPeso molecolare:505.44GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Formula:C26H21F3N4OColore e forma:SolidPeso molecolare:462.47Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Formula:C18H18N2O4Colore e forma:SolidPeso molecolare:326.35PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Formula:C14H22BO4PColore e forma:SolidPeso molecolare:296.11mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Formula:C93H150N20O25Purezza:99.26%Colore e forma:SolidPeso molecolare:1948.312,5-Dihydroxybiphenyl
CAS:<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Formula:C12H10O2Purezza:99.66%Colore e forma:White To Grey-Brownish PowderPeso molecolare:186.21Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Formula:C19H19ClF2N4O3SColore e forma:SolidPeso molecolare:456.89D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Formula:C17H15N5OSColore e forma:SolidPeso molecolare:337.4ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Formula:C29H32ClN5O4Purezza:98.81%Colore e forma:SolidPeso molecolare:550.05UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Formula:C25H22ClNO2Colore e forma:SolidPeso molecolare:403.9ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Formula:C16H11Cl2FN4O2Colore e forma:SolidPeso molecolare:381.19Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Formula:C8H16O2S2Purezza:97.51%Colore e forma:Yellow To Orange LiquidPeso molecolare:208.34
