Raf
Le chinasi Raf sono componenti chiave della via di segnalazione MAPK/ERK, svolgendo un ruolo critico nella trasmissione dei segnali dalla membrana cellulare al nucleo. L'attivazione di Raf porta alla fosforilazione di MEK, che successivamente attiva ERK, influenzando la divisione, la differenziazione e la sopravvivenza cellulare. Le mutazioni in Raf, in particolare in B-Raf, sono associate a vari tipi di cancro, rendendo Raf un bersaglio cruciale nella terapia del cancro. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di Raf per supportare la tua ricerca in oncologia, trasduzione del segnale e sviluppo terapeutico.
Trovati 81 prodotti per "Raf".
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Pepinh-TRIF TFA
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interactionFormula:C180H279F3N58O40S2Purezza:98%Colore e forma:SolidPeso molecolare:4014.09741Sorafenib tosylate
CAS:Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).Formula:C21H16ClF3N4O3·C7H8O3SPurezza:99.24% - 99.94%Colore e forma:SolidPeso molecolare:637.03LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Formula:C25H25F3N4O4Purezza:98.30% - 99.92%Colore e forma:White SolidPeso molecolare:502.49Ref: TM-T11898
1mg50,00€5mg115,00€1mL*10mM (DMSO)128,00€10mg175,00€25mg344,00€50mg537,00€100mg653,00€200mg898,00€500mg1.369,00€Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Formula:C24H19ClN4O4Purezza:95.77% - 98.83%Colore e forma:White SolidPeso molecolare:462.89MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Formula:C22H24N6OPurezza:99.69%Colore e forma:SolidPeso molecolare:388.47Sorafenib
CAS:Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57Formula:C21H16ClF3N4O3Purezza:98% - 99.89%Colore e forma:White SolidPeso molecolare:464.82B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Formula:C20H17F2N5O4SPurezza:98.86%Colore e forma:SolidPeso molecolare:461.44LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formula:C27H19F3N8OPurezza:99.03%Colore e forma:SolidPeso molecolare:528.49KG5
CAS:KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).Formula:C20H16F3N7OSPurezza:98.32%Colore e forma:SolidPeso molecolare:459.45Ref: TM-T41003
1mg33,00€2mg44,00€5mg71,00€1mL*10mM (DMSO)85,00€10mg100,00€25mg193,00€50mg296,00€100mg425,00€200mg595,00€Cyclorasin 9A5 TFA
Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.Formula:C75H108FN25O13·xC2HF3O2Colore e forma:SolidPeso molecolare:1586.82 (free base)VUBI1-octanoic acid
VUBI1-octanoic acid is a conjugate of both the SOS1 ligand and linker, and it is applied in the synthesis of (4S)-PROTAC SOS1 degrader-1.Colore e forma:Odour SolidVem-L-Cy5
Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAFFormula:C63H68F5N7O9SPurezza:98%Colore e forma:SolidPeso molecolare:1194.31MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Colore e forma:Odour SolidRef: TM-L1400
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaR18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formula:C101H157N27O29S3Purezza:98%Colore e forma:SolidPeso molecolare:2309.69Cyclorasin 9A5
CAS:Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, demonstrating an inhibitionFormula:C75H108FN25O13Purezza:98%Colore e forma:SolidPeso molecolare:1586.82SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Formula:C29H34F3N5O2Colore e forma:SolidPeso molecolare:541.61SOS1-IN-11
CAS:SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Formula:C22H24F3N5OPurezza:99.4%Colore e forma:SolidPeso molecolare:431.45Ref: TM-T60029
1mg72,00€5mg160,00€1mL*10mM (DMSO)172,00€10mg269,00€25mg427,00€50mg610,00€100mg820,00€RAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.Formula:C27H28ClF4N5O2Purezza:98.43%Colore e forma:SolidPeso molecolare:565.99Anti-Phospho-RAF1 (Ser43) Antibody (8R108)
Anti-Phospho-RAF1 (Ser43) Antibody (8R108) is an antibody targeting Phospho-RAF1 (Ser43). Anti-Phospho-RAF1 (Ser43) Antibody (8R108) can be used in ELISA, IF.Colore e forma:Odour LiquidAnti-Phospho-RAF1 (Ser621) Antibody (2K681)
Anti-Phospho-RAF1 (Ser621) Antibody (2K681) is an antibody targeting Phospho-RAF1 (Ser621). Anti-Phospho-RAF1 (Ser621) Antibody (2K681) can be used in ELISA, WB, IF.Colore e forma:Odour LiquidAnti-Phospho-RAF1 (Ser259) Antibody (5X237)
Anti-Phospho-RAF1 (Ser259) Antibody (5X237) is an antibody targeting Phospho-RAF1 (Ser259). Anti-Phospho-RAF1 (Ser259) Antibody (5X237) can be used in ELISA, WB, IHC, IF.Colore e forma:Odour LiquidRegorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:482.82Ref: TM-T1792
5mg34,00€10mg49,00€1mL*10mM (DMSO)54,00€25mg75,00€50mg90,00€100mg137,00€200mg175,00€500mg294,00€Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFormula:C21H17ClF4N4O4Purezza:99.69%Colore e forma:SolidPeso molecolare:500.83Ref: TM-T1792L
5mg34,00€10mg46,00€1mL*10mM (DMSO)55,00€25mg65,00€50mg94,00€100mg133,00€200mg197,00€500mg329,00€ZM 336372
CAS:ZM 336372 is a potent and selective c-Raf inhibitor.Formula:C23H23N3O3Purezza:97.24% - 97.51%Colore e forma:SolidPeso molecolare:389.45GW 5074
CAS:GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.Formula:C15H8Br2INO2Purezza:99.32%Colore e forma:Yellow SolidPeso molecolare:520.94Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Formula:C23H20F3N5O2S2Purezza:99.62% - >99.99%Colore e forma:SolidPeso molecolare:519.56K-Ras(G12C) inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Formula:C17H22Cl2N2O3SPurezza:89.07% - 97.09%Colore e forma:SolidPeso molecolare:405.34PLX8394
CAS:Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.Formula:C25H21F3N6O3SPurezza:98.75% - >99.99%Colore e forma:SolidPeso molecolare:542.53Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurezza:98.3% - 98.81%Colore e forma:White SolidPeso molecolare:471.46Ref: TM-T6971
1mg54,00€2mg78,00€5mg109,00€1mL*10mM (DMSO)112,00€10mg169,00€25mg311,00€50mg500,00€100mg718,00€Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Formula:C14H9F4N5O4SPurezza:98.36% - 99.39%Colore e forma:SolidPeso molecolare:419.31Agerafenib
CAS:Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.Formula:C24H22F3N5O5Purezza:95.78% - 99.23%Colore e forma:White SolidPeso molecolare:517.46Ref: TM-T2070
1mg39,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg124,00€25mg219,00€50mg358,00€100mg530,00€200mg757,00€Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurezza:98.27%Colore e forma:Yellow SolidPeso molecolare:547.99Ref: TM-T22436
1mg92,00€2mg128,00€5mg178,00€1mL*10mM (DMSO)243,00€10mg268,00€25mg439,00€50mg610,00€100mg820,00€200mg1.099,00€AZ304
CAS:AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).Formula:C27H25N5O2Purezza:99.82%Colore e forma:SolidPeso molecolare:451.52TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Formula:C27H18F4N4O3SPurezza:98% - 99.5%Colore e forma:SolidPeso molecolare:554.52I-37 free base( 2359690-13-2(free base))
I-37 free base is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.Formula:C22H24ClF3N4OPurezza:99.75%Colore e forma:SolidPeso molecolare:452.9Ref: TM-T8721L
1mg58,00€5mg118,00€1mL*10mM (DMSO)141,00€10mg172,00€25mg281,00€50mg396,00€100mg537,00€200mg742,00€RAF265
CAS:RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Formula:C24H16F6N6OPurezza:99.56%Colore e forma:White SolidPeso molecolare:518.41Ref: TM-T6296
1mg44,00€2mg59,00€5mg93,00€1mL*10mM (DMSO)94,00€10mg140,00€25mg253,00€50mg413,00€100mg605,00€AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formula:C22H19F4N7OPurezza:99.49% - 99.75%Colore e forma:SolidPeso molecolare:473.43Ref: TM-T4301
1mg44,00€1mL*10mM (DMSO)90,00€5mg96,00€10mg138,00€25mg268,00€50mg439,00€100mg645,00€500mg1.333,00€Raf inhibitor 2
CAS:Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.Formula:C15H8Br2ClNO2Purezza:98.53%Colore e forma:White SolidPeso molecolare:429.49Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Formula:C22H27ClFN7O4SPurezza:99.56% - 99.84%Colore e forma:SolidPeso molecolare:540.01B-Raf IN 11
CAS:B-Raf IN 11 is a novel selective inhibitor.Formula:C17H14BrF2N3O3SPurezza:99.94%Colore e forma:SolidPeso molecolare:458.28BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formula:C25H28N4O2SPurezza:97.16%Colore e forma:SolidPeso molecolare:448.58Ref: TM-T5418
1mg50,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg177,00€25mg321,00€50mg482,00€100mg710,00€200mg982,00€RAF709
CAS:RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.Formula:C28H29F3N4O4Purezza:99.28% - 99.8%Colore e forma:White SolidPeso molecolare:542.55Ref: TM-T3711
1mg38,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)88,00€10mg124,00€25mg245,00€50mg401,00€100mg592,00€500mg1.243,00€BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Formula:C28H33F2N7O2SPurezza:97.33% - 99.07%Colore e forma:SolidPeso molecolare:569.67K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C16H21ClIN3O4SPurezza:97.33% - 97.45%Colore e forma:SolidPeso molecolare:513.78Ref: TM-T6556
1mg34,00€5mg78,00€10mg108,00€1mL*10mM (DMSO)108,00€25mg215,00€50mg311,00€100mg425,00€200mg597,00€SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Formula:C27H27N5O2Purezza:95.42% - 99.06%Colore e forma:SolidPeso molecolare:453.54Plx-4032
CAS:Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Formula:C23H18ClF2N3O3SPurezza:98.53% - 99.94%Colore e forma:SolidPeso molecolare:489.92L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurezza:98.48%Colore e forma:SolidPeso molecolare:347.8PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formula:C17H14ClF2N3O3SPurezza:97.78% - 99.96%Colore e forma:SolidPeso molecolare:413.83CCT196969
CAS:CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.Formula:C27H24FN7O3Purezza:98.93% - 99.65%Colore e forma:SolidPeso molecolare:513.52Belvarafenib
CAS:Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.Formula:C23H16ClFN6OSPurezza:98% - 99.65%Colore e forma:Yellow SolidPeso molecolare:478.93
