Raf
Le chinasi Raf sono componenti chiave della via di segnalazione MAPK/ERK, svolgendo un ruolo critico nella trasmissione dei segnali dalla membrana cellulare al nucleo. L'attivazione di Raf porta alla fosforilazione di MEK, che successivamente attiva ERK, influenzando la divisione, la differenziazione e la sopravvivenza cellulare. Le mutazioni in Raf, in particolare in B-Raf, sono associate a vari tipi di cancro, rendendo Raf un bersaglio cruciale nella terapia del cancro. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di Raf per supportare la tua ricerca in oncologia, trasduzione del segnale e sviluppo terapeutico.
Trovati 82 prodotti di "Raf"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
LUT014
CAS:<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Formula:C27H19F3N8OPurezza:99.03%Colore e forma:SolidPeso molecolare:528.49B-Raf IN 2
CAS:<p>B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.</p>Formula:C20H17F2N5O4SPurezza:98.86%Colore e forma:SolidPeso molecolare:461.44MRTX0902
CAS:<p>MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.</p>Formula:C22H24N6OPurezza:99.69%Colore e forma:SolidPeso molecolare:388.47Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Formula:C24H19ClN4O4Purezza:95.77% - 98.83%Colore e forma:SolidPeso molecolare:462.89Sorafenib
CAS:Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57Formula:C21H16ClF3N4O3Purezza:98% - 99.89%Colore e forma:SolidPeso molecolare:464.82Sorafenib tosylate
CAS:<p>Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).</p>Formula:C21H16ClF3N4O3·C7H8O3SPurezza:99.24% - 99.94%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:637.03LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Formula:C25H25F3N4O4Purezza:98.3% - 99.92%Colore e forma:SolidPeso molecolare:502.49Regorafénib N-oxyde (M2)
CAS:<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>Formula:C21H15ClF4N4O4Purezza:98.03% - 98.26%Colore e forma:SolidPeso molecolare:498.81Vem-L-Cy5
Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAFFormula:C63H68F5N7O9SPurezza:98%Colore e forma:SolidPeso molecolare:1194.31R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formula:C101H157N27O29S3Purezza:98%Colore e forma:SolidPeso molecolare:2309.69Cyclorasin 9A5
CAS:<p>Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, demonstrating an inhibition</p>Formula:C75H108FN25O13Purezza:98%Colore e forma:SolidPeso molecolare:1586.82Cyclorasin 9A5 TFA
<p>Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.</p>Formula:C75H108FN25O13·xC2HF3O2Colore e forma:SolidPeso molecolare:1586.82 (free base)SOS1-IN-11
CAS:<p>SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).</p>Formula:C22H24F3N5OPurezza:99.4%Colore e forma:SolidPeso molecolare:431.45SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Formula:C29H34F3N5O2Colore e forma:SolidPeso molecolare:541.61MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Colore e forma:Odour SolidVUBI1-octanoic acid
VUBI1-octanoic acid is a conjugate of both the SOS1 ligand and linker, and it is applied in the synthesis of (4S)-PROTAC SOS1 degrader-1.Colore e forma:Odour SolidKG5
CAS:<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>Formula:C20H16F3N7OSPurezza:98.32%Colore e forma:SolidPeso molecolare:459.45PROTAC B-Raf degrader 1
CAS:PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.Formula:C36H37N5O12SPurezza:98%Colore e forma:SolidPeso molecolare:763.77Anti-Phospho-RAF1 (Ser259) Antibody (5X237)
<p>Anti-Phospho-RAF1 (Ser259) Antibody (5X237) is an antibody targeting Phospho-RAF1 (Ser259). Anti-Phospho-RAF1 (Ser259) Antibody (5X237) can be used in ELISA, WB, IHC, IF.</p>Colore e forma:Odour LiquidAnti-Phospho-RAF1 (Ser621) Antibody (2K681)
Anti-Phospho-RAF1 (Ser621) Antibody (2K681) is an antibody targeting Phospho-RAF1 (Ser621). Anti-Phospho-RAF1 (Ser621) Antibody (2K681) can be used in ELISA, WB, IF.Colore e forma:Odour LiquidAnti-Phospho-RAF1 (Ser43) Antibody (8R108)
Anti-Phospho-RAF1 (Ser43) Antibody (8R108) is an antibody targeting Phospho-RAF1 (Ser43). Anti-Phospho-RAF1 (Ser43) Antibody (8R108) can be used in ELISA, IF.Colore e forma:Odour LiquidRAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.Formula:C27H28ClF4N5O2Purezza:98.43%Colore e forma:SolidPeso molecolare:565.99GW 5074
CAS:GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.Formula:C15H8Br2INO2Purezza:99.32%Colore e forma:SolidPeso molecolare:520.94Regorafenib monohydrate
CAS:<p>Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine</p>Formula:C21H17ClF4N4O4Purezza:99.69%Colore e forma:SolidPeso molecolare:500.83PLX8394
CAS:<p>Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.</p>Formula:C25H21F3N6O3SPurezza:98.75% - >99.99%Colore e forma:SolidPeso molecolare:542.53Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurezza:98.3% - 98.81%Colore e forma:SolidPeso molecolare:471.46Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Formula:C14H9F4N5O4SPurezza:98.36% - 99.39%Colore e forma:SolidPeso molecolare:419.31Agerafenib
CAS:Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.Formula:C24H22F3N5O5Purezza:95.78% - 99.23%Colore e forma:SolidPeso molecolare:517.46Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurezza:98.27%Colore e forma:SolidPeso molecolare:547.99AZ304
CAS:<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Formula:C27H25N5O2Purezza:99.82%Colore e forma:SolidPeso molecolare:451.52TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Formula:C27H18F4N4O3SPurezza:98% - 99.5%Colore e forma:SolidPeso molecolare:554.52RAF265
CAS:RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Formula:C24H16F6N6OPurezza:99.56%Colore e forma:SolidPeso molecolare:518.41AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formula:C22H19F4N7OPurezza:99.49% - 99.75%Colore e forma:SolidPeso molecolare:473.43Raf inhibitor 2
CAS:Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.Formula:C15H8Br2ClNO2Purezza:98.53%Colore e forma:SolidPeso molecolare:429.49Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Formula:C22H27ClFN7O4SPurezza:99.51% - 99.83%Colore e forma:SolidPeso molecolare:540.01B-Raf IN 11
CAS:B-Raf IN 11 is a novel selective inhibitor.Formula:C17H14BrF2N3O3SPurezza:99.947%Colore e forma:SolidPeso molecolare:458.28BAY-293
CAS:<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Formula:C25H28N4O2SPurezza:97.16%Colore e forma:SolidPeso molecolare:448.58RAF709
CAS:<p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>Formula:C28H29F3N4O4Purezza:99.28% - 99.8%Colore e forma:SolidPeso molecolare:542.55BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Formula:C28H33F2N7O2SPurezza:97.33% - 99.07%Colore e forma:SolidPeso molecolare:569.67K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C16H21ClIN3O4SPurezza:97.33% - 97.45%Colore e forma:SolidPeso molecolare:513.78SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Formula:C27H27N5O2Purezza:95.42% - 99.06%Colore e forma:SolidPeso molecolare:453.54Plx-4032
CAS:Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Formula:C23H18ClF2N3O3SPurezza:98.53% - 99.36%Colore e forma:SolidPeso molecolare:489.92Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:482.82K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formula:C17H22Cl2N2O3SPurezza:89.07% - 97.09%Colore e forma:SolidPeso molecolare:405.34ZM 336372
CAS:ZM 336372 is a potent and selective c-Raf inhibitor.Formula:C23H23N3O3Purezza:97.24% - 97.51%Colore e forma:SolidPeso molecolare:389.45L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurezza:≥95%Colore e forma:SolidPeso molecolare:347.8PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formula:C17H14ClF2N3O3SPurezza:97.78% - 99.83%Colore e forma:SolidPeso molecolare:413.83CCT196969
CAS:CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.Formula:C27H24FN7O3Purezza:98.93% - 99.65%Colore e forma:SolidPeso molecolare:513.52Belvarafenib
CAS:Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.Formula:C23H16ClFN6OSPurezza:98% - 99.65%Colore e forma:SolidPeso molecolare:478.93I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFormula:C23H26ClF3N4O2Purezza:99.64% - 99.88%Colore e forma:SolidPeso molecolare:482.92
