Raf
Le chinasi Raf sono componenti chiave della via di segnalazione MAPK/ERK, svolgendo un ruolo critico nella trasmissione dei segnali dalla membrana cellulare al nucleo. L'attivazione di Raf porta alla fosforilazione di MEK, che successivamente attiva ERK, influenzando la divisione, la differenziazione e la sopravvivenza cellulare. Le mutazioni in Raf, in particolare in B-Raf, sono associate a vari tipi di cancro, rendendo Raf un bersaglio cruciale nella terapia del cancro. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di Raf per supportare la tua ricerca in oncologia, trasduzione del segnale e sviluppo terapeutico.
Trovati 81 prodotti per "Raf".
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Formula:C29H24F3N5OPurezza:97.22% - 99.27%Colore e forma:SolidPeso molecolare:515.53Vemurafenib
CAS:Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.Formula:C23H18ClF2N3O3SPurezza:98% - 99.65%Colore e forma:SolidPeso molecolare:489.92LY3009120
CAS:LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.Formula:C23H29FN6OPurezza:96.96% - ≥95%Colore e forma:Yellow SolidPeso molecolare:424.51PROTAC BRAF-V600E degrader-1
CAS:PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.Formula:C48H54F2N10O10SPurezza:99.43%Colore e forma:SolidPeso molecolare:1001.07KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.Formula:C110H186N44O27S2Purezza:99.34%Colore e forma:SolidPeso molecolare:2621.06Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Formula:C24H24F3N5O5S3Purezza:99.45% - 99.82%Colore e forma:SolidPeso molecolare:615.67Doramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Formula:C31H37N5O3Purezza:97.14% - 98.80%Colore e forma:SolidPeso molecolare:527.66Ref: TM-T6277
5mg34,00€1mL*10mM (DMSO)42,00€10mg52,00€25mg74,00€50mg96,00€100mg120,00€200mg213,00€500mg359,00€1g532,00€TAK-580
CAS:TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.Formula:C17H12Cl2F3N7O2SPurezza:99.60% - 99.77%Colore e forma:White SolidPeso molecolare:506.29Regorafenib Hydrochloride
CAS:Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Formula:C21H16Cl2F4N4O3Purezza:99.56%Colore e forma:SolidPeso molecolare:519.28AZ 628
CAS:AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.Formula:C27H25N5O2Purezza:99.50%Colore e forma:SolidPeso molecolare:451.52Raf inhibitor 1 dihydrochloride
CAS:Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8HClPurezza:98.19% - 99.54%Colore e forma:SolidPeso molecolare:551.86Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8Purezza:99.91%Colore e forma:SolidPeso molecolare:478.94TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formula:C27H23F2N7O3Purezza:99.28% - 99.58%Colore e forma:Yellow SolidPeso molecolare:531.51Ref: TM-T9693
1mg46,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg147,00€25mg258,00€50mg386,00€100mg537,00€200mg710,00€PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Formula:C24H22F2N6O3SPurezza:99.51% - 99.66%Colore e forma:SolidPeso molecolare:512.53GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Formula:C19H18N4O2Purezza:99.62%Colore e forma:SolidPeso molecolare:334.37Ref: TM-T6320
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg205,00€50mg334,00€100mg537,00€200mg765,00€RAF-IN-1
CAS:RAF-IN-1 inhibits cRAF, BRAF and BRAFV600E, with GI50 3.4 and 2.9 nM in mutant cell lines.Formula:C26H22F3N3O4Purezza:99.62%Colore e forma:White SolidPeso molecolare:497.47Ref: TM-T63365
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta1mg447,00€5mg1.009,00€MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Formula:C33H36N2O3Purezza:97.23%Colore e forma:OilPeso molecolare:508.65Ref: TM-T24437
1mg34,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg160,00€25mg276,00€50mg400,00€100mg532,00€500mg1.063,00€B-Raf IN 13
CAS:B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.Formula:C19H19ClFN3O4SPurezza:99.41% - >99.99%Colore e forma:SolidPeso molecolare:439.89BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Formula:C22H18F2N4O3SPurezza:98.2% - 98.41%Colore e forma:SolidPeso molecolare:456.47Ref: TM-T10599
1mg44,00€5mg87,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg236,00€50mg371,00€100mg530,00€200mg770,00€GSK2008607
CAS:GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.Formula:C31H28F3N7O3S2Purezza:99.99%Colore e forma:SolidPeso molecolare:667.72Ref: TM-T27454
1mg315,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€SOS1-IN-15
CAS:SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Formula:C28H27F3N6O2Purezza:98.32%Colore e forma:SolidPeso molecolare:536.548B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formula:C20H19N5O3SPurezza:99.31% - 99.78%Colore e forma:SolidPeso molecolare:409.46Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormula:C25H17F3N4O3Purezza:97.99% - 98%Colore e forma:SolidPeso molecolare:478.42Ref: TM-T22272
50mgPrezzo su richiesta100mgPrezzo su richiesta1mg34,00€5mg65,00€10mg92,00€1mL*10mM (DMSO)94,00€25mg180,00€B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formula:C19H15N3OSPurezza:98%Colore e forma:SolidPeso molecolare:333.41Uplarafenib
CAS:Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Formula:C22H21F3N4O4SPurezza:99.98%Colore e forma:SolidPeso molecolare:494.49Ref: TM-T63333
1mg54,00€5mg119,00€1mL*10mM (DMSO)131,00€10mg170,00€25mg359,00€50mg538,00€100mg928,00€Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formula:C18H19FN8O2SPurezza:98%Colore e forma:SolidPeso molecolare:430.46HG6-64-1
CAS:HG6-64-1 (HMSL 10017-101-1, compound 9 (XI-1)) is a potent and selective B-Raf inhibitor with an IC50 = 0.09 μM in B-raf V600E-transformed Ba/F3 cells.Formula:C32H34F3N5O2Purezza:99.89%Colore e forma:SolidPeso molecolare:577.64Ref: TM-T15480
1mg69,00€5mg147,00€1mL*10mM (DMSO)178,00€10mg215,00€25mg371,00€50mg522,00€100mg708,00€Brimarafenib
CAS:Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.Formula:C24H17F3N4O4Purezza:98.32%Colore e forma:White SolidPeso molecolare:482.41Ref: TM-T89116
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta1mg172,00€5mg376,00€pan-Raf/RTK inhibitor 1
CAS:Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf). It exhibits antiproliferative activity against various cancer cell lines and can be utilized in cancer research.Formula:C29H28F3N7O3Colore e forma:SolidPeso molecolare:579.573Rineterkib
CAS:Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.Formula:C26H27BrF3N5O2Purezza:99.73%Colore e forma:SolidPeso molecolare:578.42Ref: TM-T11224
1mg87,00€5mg170,00€1mL*10mM (DMSO)224,00€10mg318,00€25mg538,00€50mg765,00€100mg1.035,00€I-37 free base( 2359690-13-2(free base))
I-37 free base is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.Formula:C22H24ClF3N4OPurezza:99.75%Colore e forma:SolidPeso molecolare:452.9
