Canale TRP/TRPV

Optovin is a TRPA1 activator, which is reversibly photoactivated.

AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).

CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of …

AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).

A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.

Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current …

TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of …

ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.

N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.

Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits (−)-englerin A-activated TRPC4/TRPC5 channels (IC50s: …

Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is …

JT010 is an effective agonist of TRPA1 (EC50: 0.65 nM).

A 425619 is a potent TRPV1 antagonist

TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally …

ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.

WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 …

EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel …

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.

GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: …

JYL 1421 is an antagonist of TRPV1 receptor (IC50: 8 nM).

GSK2193874 was identified as a selective, orally active TRPV4 blocker.

GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: …

BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 …

Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of …

SAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).

RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: …

Camphor is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is …

Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation …

TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate …

IA-Alkyne is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically …

GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM …

Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the …

GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with …

PF-05105679 has the potential for cold-related pain. PF-05105679 is an orally active and selective TRPM8 …

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) …

AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe …

Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin …

TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 …

BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 …

EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits …

TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells …

JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 …

Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the …

RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and …

trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma …

SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in …

Probenecid is a benzoic acid derivative with antihyperuricemic property.

Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide …

Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.

ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.

Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by …

SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).

Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) …

NSC 139486 is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.

TRPM4-IN-1 is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.

HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through …

Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist.

Ononetin is a TRPM3 channel blocker(IC50: 0.3 μM).

A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 …

PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited …

(+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with …

TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 …