Canale del potassio
I canali del potassio sono un gruppo diversificato di proteine di membrana che facilitano il flusso di ioni potassio (K+) attraverso la membrana cellulare. Questi canali svolgono un ruolo cruciale nel mantenimento del potenziale di membrana a riposo, nella regolazione del volume cellulare e nel controllo dell'eccitabilità dei neuroni e delle cellule muscolari. I canali del potassio sono coinvolti in vari processi fisiologici, tra cui la regolazione del ritmo cardiaco, la secrezione di insulina e il rilascio di neurotrasmettitori. La disfunzione dei canali del potassio è legata a condizioni come aritmie, epilessia e ipertensione. Presso CymitQuimica, offriamo una vasta gamma di modulatori dei canali del potassio per supportare la tua ricerca in elettrofisiologia, salute cardiovascolare e neurobiologia.
Trovati 280 prodotti di "Canale del potassio"
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NS13001
CAS:NS13001, an oral SK channel modulator, shows promise for SCA2 therapy; EC50: 1.8 µM (SK2), 0.14 µM (SK3).Formula:C17H16ClN7Purezza:99.55%Colore e forma:SolidPeso molecolare:353.81Disopyramide
CAS:Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.Formula:C21H29N3OPurezza:99.62%Colore e forma:SolidPeso molecolare:339.47Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurezza:99% - 99.99%Colore e forma:Off-White To Yellow SolidPeso molecolare:414.77Quinidine hydrochloride monohydrate
CAS:Quinidine hydrochloride monohydrate is an optical isomer of quinine. Quinidine prolongs cellular action potential and decreases automaticity.Formula:C20H27ClN2O3Purezza:94.4% - 99.68%Colore e forma:SolidPeso molecolare:378.89Dronedarone hydrochloride
CAS:Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5S·HClPurezza:99.61%Colore e forma:SolidPeso molecolare:593.22Ref: TM-T1073
5mg38,00€10mg52,00€25mg87,00€50mg117,00€100mg170,00€200mg250,00€500mg424,00€1mL*10mM (DMSO)55,00€Diazoxide
CAS:Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.Formula:C8H7ClN2O2SPurezza:99% - 99.83%Colore e forma:SolidPeso molecolare:230.67BMS-394136
CAS:BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.Formula:C24H21Cl2FN4OPurezza:98.59% - 99.95%Colore e forma:SolidPeso molecolare:471.35ICA-27243
CAS:<p>ICA-27243: Potent KCNQ2/Q3 opener, oral, EC50 0.38 μM; less effective on KCNQ4, KCNQ3/Q5; antiepileptic.</p>Formula:C12H7ClF2N2OPurezza:99.54%Colore e forma:SolidPeso molecolare:268.65VU0134992 hydrochloride
CAS:VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 μM).Formula:C20H32BrClN2O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:447.84Ref: TM-T13316
5mg37,00€10mg59,00€25mg104,00€50mg170,00€100mg283,00€200mg437,00€1mL*10mM (DMSO)42,00€IK1 inhibitor PA-6
CAS:IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouseFormula:C31H32N4O2Purezza:98.9%Colore e forma:SolidPeso molecolare:492.61NS5806
CAS:NS5806 activates K+ currents, slows KV4.2/4.3 decay with KChIP2, and boosts KV4.3/KChIP2 peaks (EC50=5.3μM).Formula:C16H8Br2F6N6OPurezza:97.95%Colore e forma:SolidPeso molecolare:574.07Flufenamic acid
CAS:<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Formula:C14H10F3NO2Purezza:98.68%Colore e forma:White To Light Yellow Crystalline PowderPeso molecolare:281.23Eleclazine hydrochloride
CAS:Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).Formula:C21H17ClF3N3O3Purezza:99.86%Colore e forma:SolidPeso molecolare:451.83Ref: TM-T15207
1mg62,00€5mg116,00€10mg170,00€25mg283,00€50mg424,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)128,00€Ketanserin
CAS:Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.Formula:C22H22FN3O3Purezza:99.19% - 99.73%Colore e forma:SolidPeso molecolare:395.43Hydroxyhexamide
CAS:Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.Formula:C15H22N2O4SPurezza:98.91%Colore e forma:SolidPeso molecolare:326.41Cloperastine hydrochloride
CAS:Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.Formula:C20H25Cl2NOPurezza:97.74% - 99.42%Colore e forma:SolidPeso molecolare:366.33ADWX 1 TFA
ADWX 1 TFA is a novel peptide that potently targets and inhibits the Kv1.3 channel, with an IC50 of 1.89 pM. It specifically suppresses the activity of the Kv1.3 channel, in addition to inhibiting initial calcium signaling and NF-κB activation. This compound has been shown to ameliorate symptoms in rats with experimental autoimmune encephalomyelitis (EAE). ADWX 1 TFA is utilized in research focused on T-cell-mediated autoimmune diseases.Formula:C169H281N57O46S7·xC2HF3O2Colore e forma:SolidPeso molecolare:4071.85 (free base)ADWX 1
Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.Formula:C169H281N57O46S7Purezza:98%Colore e forma:SolidPeso molecolare:4071.86Potassium Channel Targeted Library
A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;Colore e forma:Odour SolidRef: TM-L7300
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaIon Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Colore e forma:Odour SolidTertiapin LQ
Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.Formula:C106H179N33O24S4Purezza:98%Colore e forma:SolidPeso molecolare:2428.03Aekatperone
Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).Formula:C20H25N5O2SColore e forma:SolidPeso molecolare:399.51GsAF-I
GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28Formula:C160H244N46O42S7Purezza:98%Colore e forma:SolidPeso molecolare:3708.39Apamin acetate
Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.Purezza:96.97%Colore e forma:SolidPhe-Met-Arg-Phe amide trifluoroacetate
CAS:Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.Formula:C33H44F6N8O8SPurezza:98%Colore e forma:SolidPeso molecolare:826.81Dalazatide HCl
Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,Colore e forma:SolidPeso molecolare:4317.53 (Free base)Foslevcromakalim
CAS:Foslevcromakalim (QLS-101) is an KATP opener, converted to its active form by alkaline phosphatase in vivo, reduces intraocular pressure in normotensive mice.Formula:C16H19N2O6PColore e forma:SolidPeso molecolare:366.31Lei-Dab7 TFA
Lei-Dab7 TFA blocks SK2 channels with 3.8 nM affinity, is >200x selective, and enhances LTP in rat hippocampus.Formula:C143H237F3N46O41S6Colore e forma:SolidPeso molecolare:3506.08Ebio2
Ebio2 is an effective activator of KCNQ2.Formula:C17H19F2N3O2Colore e forma:SolidPeso molecolare:335.349Tertiapin
CAS:Tertiapin (reduced) is a synthetic bee venom peptide characterized by disulfide bonds between Cys3-Cys14 and Cys5-Cys18. It acts as an inhibitor of inward-rectifying potassium channels (potassium Channel) and can also block the activity of calcium-activated large conductance potassium channels. Tertiapin (reduced) is utilized in research related to diseases such as rheumatoid arthritis and multiple sclerosis.Formula:C106H180N34O23S5Colore e forma:SolidPeso molecolare:2459.1BeKm-1
CAS:Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.Formula:C174H261N51O52S6Purezza:98%Colore e forma:SolidPeso molecolare:4091.65ShK-Dap22
CAS:Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Formula:C166H268N54O48S7Purezza:98%Colore e forma:SolidPeso molecolare:4012.7Guangxitoxin 1E
CAS:Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.Formula:C178H248N44O45S7Purezza:98%Colore e forma:SolidPeso molecolare:3948.61Phe-Met-Arg-Phe, amide
CAS:Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.Formula:C29H42N8O4SPurezza:98%Colore e forma:SolidPeso molecolare:598.76Pinacidil monohydrate
CAS:Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.Formula:C13H21N5OPurezza:99.94% - 99.98%Colore e forma:PowderPeso molecolare:263.34MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.Formula:C22H21N7O3SColore e forma:SolidPeso molecolare:463.512Lei-Dab7
CAS:Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Formula:C141H236N46O39S6Purezza:98%Colore e forma:SolidPeso molecolare:3392.06GsAF-II
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodiumFormula:C176H261N47O45S7Purezza:98%Colore e forma:SolidPeso molecolare:3979.7Heteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Formula:C168H238N46O51S6Purezza:98%Colore e forma:SolidPeso molecolare:3910.35AmmTX3
KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.Formula:C158H262N50O48S6Purezza:98%Colore e forma:SolidPeso molecolare:3822.47Ebio3
Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.Formula:C19H23F2N3O2Colore e forma:SolidPeso molecolare:363.4Dendrotoxin K
CAS:Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.Formula:C294H462N84O75S6Colore e forma:SolidPeso molecolare:6559.66BKCa activator-1
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.Formula:C22H23F7N2O3Colore e forma:SolidPeso molecolare:496.418Guanfu base A
CAS:Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.Formula:C24H31NO6Purezza:99.71% - 99.85%Colore e forma:SolidPeso molecolare:429.5HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formula:C337H503N103O97S6Peso molecolare:7736.59176Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Formula:C179H274N50O55S7Purezza:98%Colore e forma:SolidPeso molecolare:4230Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Formula:C169H278N54O48S8Purezza:98%Colore e forma:SolidPeso molecolare:4090.87Apamin
CAS:Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.Formula:C79H131N31O24S4Purezza:98%Colore e forma:SolidPeso molecolare:2027.34Charybdotoxin
CAS:Specific inhibitor of the big conductance Ca2+-activated K+ channel.Formula:C176H277N57O55S7Purezza:98%Colore e forma:SolidPeso molecolare:4295.95Margatoxin
CAS:KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.Formula:C178H286N52O50S7Purezza:98%Colore e forma:SolidPeso molecolare:4178.96
