Canale del potassio
I canali del potassio sono un gruppo diversificato di proteine di membrana che facilitano il flusso di ioni potassio (K+) attraverso la membrana cellulare. Questi canali svolgono un ruolo cruciale nel mantenimento del potenziale di membrana a riposo, nella regolazione del volume cellulare e nel controllo dell'eccitabilità dei neuroni e delle cellule muscolari. I canali del potassio sono coinvolti in vari processi fisiologici, tra cui la regolazione del ritmo cardiaco, la secrezione di insulina e il rilascio di neurotrasmettitori. La disfunzione dei canali del potassio è legata a condizioni come aritmie, epilessia e ipertensione. Presso CymitQuimica, offriamo una vasta gamma di modulatori dei canali del potassio per supportare la tua ricerca in elettrofisiologia, salute cardiovascolare e neurobiologia.
Trovati 318 prodotti per "Canale del potassio".
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GsAF-II
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodiumFormula:C176H261N47O45S7Purezza:98%Colore e forma:SolidPeso molecolare:3979.7Foslevcromakalim
CAS:Foslevcromakalim (QLS-101) is an KATP opener, converted to its active form by alkaline phosphatase in vivo, reduces intraocular pressure in normotensive mice.Formula:C16H19N2O6PPurezza:99.73%Colore e forma:White SolidPeso molecolare:366.31κM-Conotoxin RIIIJ
κM-Conotoxin RIIIJ (κM-RIIIJ) selectively inhibits Kv1.2 channels, exhibiting an IC50 value of 33 nM [1].Formula:C117H184N32O36S6Purezza:98%Colore e forma:SolidPeso molecolare:2807.3Heteropodatoxin-1
Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9Formula:C168H238N46O51S6Purezza:98%Colore e forma:SolidPeso molecolare:3910.35Slotoxin
Slotoxin, a peptide extracted from the venom of the Centruroides noxius Hoffmann scorpion, inhibits high-conductance calcium-activated potassium channels with aFormula:C177H275N47O50S7Purezza:98%Colore e forma:SolidPeso molecolare:4085.82(S)-(+)-Docosahexaenyl-2'-hydroxy-1'-propylamide
(S)-(+)-Docosahexaenyl-2'-hydroxy-1'-propylamide (N-Docosahexacnoylethanolamide(22:6)) is a homologue of dehydroepiandrosterone (DHEA). This compound can block Shaker-related voltage-gated potassium channels and inhibits Kv1.2 K+ currents with an IC50 value of 1.5 μM.Colore e forma:Odour SolidAmmTX3
KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.Formula:C158H262N50O48S6Purezza:98%Colore e forma:SolidPeso molecolare:3822.47Iberiotoxin
CAS:Selective blocker of the big conductance Ca2+-activated K+ channel.Formula:C179H274N50O55S7Purezza:98%Colore e forma:SolidPeso molecolare:4230Thalidomide-O-Triazole-C4-amino
CAS:Thalidomide-O-Triazole-C4-amino is an E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-linker conjugate) designed for the synthesis of aTAG 4531.Formula:C20H22N6O5Colore e forma:SolidPeso molecolare:426.43MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.Formula:C22H21N7O3SColore e forma:SolidPeso molecolare:463.512Ebio3
Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.Formula:C19H23F2N3O2Colore e forma:SolidPeso molecolare:363.4BKCa activator-1
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.Formula:C22H23F7N2O3Colore e forma:SolidPeso molecolare:496.418Tertiapin
CAS:Tertiapin (reduced) is a synthetic bee venom peptide characterized by disulfide bonds between Cys3-Cys14 and Cys5-Cys18. It acts as an inhibitor of inward-rectifying potassium channels (potassium Channel) and can also block the activity of calcium-activated large conductance potassium channels. Tertiapin (reduced) is utilized in research related to diseases such as rheumatoid arthritis and multiple sclerosis.Formula:C106H180N34O23S5Colore e forma:SolidPeso molecolare:2459.1Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;Colore e forma:Odour SolidRef: TM-L2300
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaKV1.3-IN-1
KV1.3-IN-1 (Compound trans-18), a selective KV1.3 channel inhibitor with IC50 values of 230 nM in Ltk cells and 26.12 nM in PHA-activated T-lymphocytes,Formula:C23H30N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:430.56Iberiotoxin TFA
Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, exhibiting a dissociation constant (Kd) of approximately 1 nM, yet itFormula:C179H274N50O55S7·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:4230.85 (free base)Tamapin TFA
Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small conductance Ca(2+)-activated KFormula:C146H238N44O41S6·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:3458.11 (free base)Pandinotoxin Kα
CAS:Pandinotoxin Kα, a chemical compound extracted from the emperor scorpion (Pandinus imperator) venom, functions as an inhibitor of the A-type potassium channel [Formula:C169H267N53O48S7Purezza:98%Colore e forma:SolidPeso molecolare:4033.71Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Formula:C169H278N54O48S8Purezza:98%Colore e forma:SolidPeso molecolare:4090.87KTX-Sp2
KTX-Sp2, a potassium channel toxin, effectively blocks exogenous voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.3, as well inhibits the endogenous Kv1.3Formula:C155H244N58O49S7Purezza:98%Colore e forma:SolidPeso molecolare:3928.41Apamin
CAS:Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.Formula:C79H131N31O24S4Purezza:98%Colore e forma:SolidPeso molecolare:2027.34Margatoxin
CAS:KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.Formula:C178H286N52O50S7Purezza:98%Colore e forma:SolidPeso molecolare:4178.96HG1 Toxin
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.Formula:C337H503N103O97S6Peso molecolare:7736.59176Charybdotoxin
CAS:Specific inhibitor of the big conductance Ca2+-activated K+ channel.Formula:C176H277N57O55S7Purezza:98%Colore e forma:SolidPeso molecolare:4295.95Dendrotoxin-I
CAS:Dendrotoxin-I, a neurotoxin from Dendroaspis snake venom, potently blocks K⁺ channels, specifically targeting voltage-gated potassium channel subunits KV1.1 andFormula:C312H491N99O83S6Purezza:98%Colore e forma:SolidPeso molecolare:7149.24AmmTX3 TFA
AmmTX3 TFA, a peptide toxin derived from Androctonus mauretanicus scorpion venom, functions as a selective blocker of the K_v4 channel.Formula:C158H262N50O48S6·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:3822.47 (free acid)Hongotoxin-1
Hongotoxin-1, a chemical compound isolated from the venom of Centruroides limbatus, functions as a potassium channel inhibitor.Formula:C181H299N53O49S7Purezza:98%Colore e forma:SolidPeso molecolare:4226.13Vm24-toxin
CAS:Vm24-toxin, a peptide toxin isolated from the Mexican scorpion Vaejovis mexicanus smithi, serves as an inhibitor of the Kv1.3 potassium channel [1].Formula:C157H253N51O45S9Purezza:98%Colore e forma:SolidPeso molecolare:3863.59ShK toxin
CAS:ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the voltage-dependent potassium channel (Kv1.3 channel).Formula:C169H274N54O48S7Purezza:98%Colore e forma:SolidPeso molecolare:4054.8Jingzhaotoxin-X
Jingzhaotoxin-X (JZTX-X) selectively inhibits Kv4.2 and Kv4.3 potassium channels, resulting in prolonged mechanical hyperalgesia [1].Formula:C164H242N46O41S6Purezza:98%Colore e forma:SolidPeso molecolare:3706.35Stromatoxin 1
CAS:Stromatoxin 1, a peptide isolated from tarantulas, acts as an inhibitor of various potassium channels, including K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3.Formula:C156H237N49O48S7Purezza:98%Colore e forma:SolidPeso molecolare:3791.31Tamapin
Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated KFormula:C146H238N44O41S6Purezza:98%Colore e forma:SolidPeso molecolare:3458.11Noxiustoxin
CAS:Noxiustoxin, a toxin extracted from the venom of the Mexican scorpion Centruroides noxius, inhibits both the voltage-dependent potassium channel (Kv1.3, IC50 =Formula:C174H286N52O54S7Purezza:98%Colore e forma:SolidPeso molecolare:4195BmP02
BmP02, a compound isolated from Chinese scorpion (Buthus martensi Karsch) venom, acts as a selective Kv1.3 channel blocker and a highly-selective Kv4.2Formula:C115H182N36O41S7Purezza:98%Colore e forma:SolidPeso molecolare:2949.35δ-Dendrotoxin
CAS:δ-Dendrotoxin is a potassium (K+) channel blocker derived from black mamba snake venom and is utilized in neurological disease research [1].Formula:C296H452N82O76S6Purezza:98%Colore e forma:SolidPeso molecolare:6567.65Ssm spooky toxin
Ssm Spooky Toxin, derived from Scolopendra mutilans, exhibits potent lethality affecting both hematological and respiratory systems primarily through theFormula:C270H413N69O79S4Purezza:98%Colore e forma:SolidPeso molecolare:6017.84Hemitoxin
Hemitoxin, a scorpion-venom peptide, functions as a K+ channel blocker and selectively inhibits rat Kv1.1, Kv1.2, and Kv1.3 channels expressed in XenopusFormula:C159H259N49O49S8Purezza:98%Colore e forma:SolidPeso molecolare:3897.58Tertiapin-RQ
Tertiapin-RQ, an inward rectifier potassium (K+) channel-blocking peptide, exhibits antidepressant effects [1].Formula:C106H175N37O25S4Purezza:98%Colore e forma:SolidPeso molecolare:2496.02Kv3.1 modulator 2
Kv3.1 modulator 2 is an agent that regulates Kv3.1 channels, exhibiting an EC50 value of 68 nM.Formula:C22H20ClN5O3Colore e forma:SolidPeso molecolare:437.12547HsTX1
CAS:HsTX1, a 34-residue, C-terminally amidated peptide isolated from the scorpion Heterometrus spinnifer, features four disulfide bridges and acts as a potassiumFormula:C149H246N54O46S9Purezza:98%Colore e forma:SolidPeso molecolare:3818.47RU-TRAAK-2
CAS:RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.Formula:C19H17N3OSPurezza:99.81%Colore e forma:SolidPeso molecolare:335.42Ref: TM-T60061
1mg77,00€5mg166,00€1mL*10mM (DMSO)172,00€10mg250,00€25mg429,00€50mg587,00€100mg827,00€200mg1.108,00€ShK-Dap22
CAS:Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Formula:C166H268N54O48S7Purezza:98%Colore e forma:SolidPeso molecolare:4012.7Ebio2
Ebio2 is an effective activator of KCNQ2.Formula:C17H19F2N3O2Colore e forma:SolidPeso molecolare:335.349Spinoxin
CAS:Spinoxin, a 34-residue peptide neurotoxin extracted from the venom of Heterometrus spinifer, is characterized by four disulfide bridges.Formula:C147H236N48O46S9Purezza:98%Colore e forma:SolidPeso molecolare:3700.33Aam-KTX
Aam-KTX, a toxic peptide sourced from Mesobuthus eupeus scorpion venom, acts as a selective K_v channel inhibitor, exhibiting IC_50 values of 1.1 nM for K_v1.3Formula:C174H288N58O48S7Purezza:98%Colore e forma:SolidPeso molecolare:4184.96Maurotoxin
CAS:Maurotoxin, a 34-residue peptide featuring four disulfide bridges, is extracted from the chactoid scorpion (Scorpio maurus) and known to impede Shaker potassiumFormula:C145H232N46O46S8Purezza:98%Colore e forma:SolidPeso molecolare:3612.19Dendrotoxin K TFA
Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1].Formula:C294H462N84O75S6·XC2HF3OC2Purezza:98%Colore e forma:SolidPeso molecolare:6559.66 (free base)Nateglinide-D5
CAS:Nateglinide D5 is a deuterium labeled Nateglinide.Formula:C19H27NO3Purezza:98%Colore e forma:SolidPeso molecolare:322.45Clamikalant sodium
CAS:Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.Formula:C19H21ClN3NaO5S2Purezza:99.95%Colore e forma:SolidPeso molecolare:493.96Ref: TM-T63330
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg164,00€25mg319,00€50mg512,00€100mg802,00€200mg1.099,00€Naminidil
CAS:Naminidil is an opener of cyanoguanidine KATP.Formula:C15H19N5Purezza:98%Colore e forma:SolidPeso molecolare:269.34
