Canale del potassio
I canali del potassio sono un gruppo diversificato di proteine di membrana che facilitano il flusso di ioni potassio (K+) attraverso la membrana cellulare. Questi canali svolgono un ruolo cruciale nel mantenimento del potenziale di membrana a riposo, nella regolazione del volume cellulare e nel controllo dell'eccitabilità dei neuroni e delle cellule muscolari. I canali del potassio sono coinvolti in vari processi fisiologici, tra cui la regolazione del ritmo cardiaco, la secrezione di insulina e il rilascio di neurotrasmettitori. La disfunzione dei canali del potassio è legata a condizioni come aritmie, epilessia e ipertensione. Presso CymitQuimica, offriamo una vasta gamma di modulatori dei canali del potassio per supportare la tua ricerca in elettrofisiologia, salute cardiovascolare e neurobiologia.
Trovati 280 prodotti di "Canale del potassio"
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UK 66914
CAS:UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias.Formula:C18H24N4O3SPurezza:99.75%Colore e forma:SolidPeso molecolare:376.47DMP-543
CAS:DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.Formula:C26H18F2N2OPurezza:99.74%Colore e forma:SolidPeso molecolare:412.43(+)-KCC2 blocker 1
CAS:(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).Formula:C22H25NO5SPurezza:99.88%Colore e forma:SolidPeso molecolare:415.5Ref: TM-T12504
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€1mL*10mM (DMSO)284,00€MK-0448
CAS:MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization current I Kur.Formula:C24H21FN4O2SPurezza:99.25% - 99.79%Colore e forma:SolidPeso molecolare:448.51GW 542573X
CAS:GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curveFormula:C19H28N2O5Purezza:99.99%Colore e forma:SolidPeso molecolare:364.44KT-362 fumarate
CAS:<p>KT-362 fumarate, a novel antagonist of Ca, K, and Na channels, induces vasodilation and relaxes rabbit arterial strips.</p>Formula:C26H32N2O7SPurezza:99.75% - 99.98%Colore e forma:SolidPeso molecolare:516.61RL648_81
CAS:RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.Formula:C17H17F4N3O2Purezza:99.82%Colore e forma:SolidPeso molecolare:371.33Sipatrigine
CAS:Sipatrigine (619C89) is an inhibitor of glutamate release, TREK ion channels, TRESK channels, sodium channels, and calcium channels.Formula:C15H16Cl3N5Purezza:98.64% - 99.77%Colore e forma:SolidPeso molecolare:372.68Ref: TM-T16887
1mg96,00€5mg202,00€10mg303,00€25mg507,00€50mg730,00€100mg1.026,00€200mg1.378,00€1mL*10mM (DMSO)224,00€IKs124
CAS:IKs124 is a KCNE2/KCNQ1 potassium channel blocker, for hKCNE1 and hKCNE3, and can be used to study peptic ulcers.Formula:C18H26N2O3SPurezza:99.53%Colore e forma:SolidPeso molecolare:350.48ZM 226600
CAS:ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.Formula:C16H14F3NO4SPurezza:99.87%Colore e forma:SolidPeso molecolare:373.35Ref: TM-T23563
2mg35,00€5mg50,00€10mg80,00€25mg145,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)55,00€Linaprazan
CAS:Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.Formula:C21H26N4O2Purezza:99.54%Colore e forma:SolidPeso molecolare:366.46Ref: TM-T10435
5mg50,00€10mg80,00€25mg145,00€50mg212,00€100mg356,00€1mL*10mM (DMSO)Prezzo su richiestaVU0463271
CAS:<p>VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>Formula:C19H18N4OS2Purezza:97.84% - 99.55%Colore e forma:SolidPeso molecolare:382.511-deoxy-PGF2a
CAS:11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contractionFormula:C20H34O4Colore e forma:SolidPeso molecolare:338.48CLP257
CAS:<p>CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.</p>Formula:C14H14FN3O2SPurezza:99.5%Colore e forma:SolidPeso molecolare:307.34Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Formula:C19H23ClFN3OPurezza:99.95%Colore e forma:SolidPeso molecolare:363.86P-1075
CAS:P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.Formula:C12H17N5Purezza:99.85%Colore e forma:SolidPeso molecolare:231.3Ref: TM-T16420
1mg60,00€5mg126,00€10mg202,00€25mg369,00€50mg560,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)96,00€Clobutinol hydrochloride
CAS:Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].Formula:C14H23Cl2NOPurezza:98%Colore e forma:SolidPeso molecolare:292.25DPO-1
CAS:DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。Formula:C22H29OPPurezza:99.78%Colore e forma:SolidPeso molecolare:340.44Ref: TM-T22745
5mg48,00€10mg74,00€25mg150,00€50mg216,00€100mg313,00€200mg437,00€1mL*10mM (DMSO)52,00€Glibornuride
CAS:Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).Formula:C18H26N2O4SPurezza:99.5%Colore e forma:SolidPeso molecolare:366.48Ref: TM-T15385
1mg74,00€5mg160,00€10mg250,00€25mg432,00€50mg612,00€100mg848,00€1mL*10mM (DMSO)170,00€MCHR1 antagonist 2
CAS:MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.Formula:C23H21FN2O5Purezza:98.29%Colore e forma:SolidPeso molecolare:424.42Ref: TM-T11966
2mg46,00€5mg70,00€10mg105,00€25mg221,00€50mg353,00€100mg567,00€200mg748,00€1mL*10mM (DMSO)85,00€Kv3 modulator 1
CAS:Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.Formula:C20H20N4O4Purezza:99.41%Colore e forma:SolidPeso molecolare:380.4C 101248
CAS:C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Formula:C15H12N6OPurezza:99.14% - 99.31%Colore e forma:SolidPeso molecolare:292.3Opakalim
CAS:<p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>Formula:C18H22F2N4OColore e forma:SolidPeso molecolare:348.39KV1.3-IN-2
CAS:<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Formula:C16H23ClN2O4Colore e forma:SolidPeso molecolare:342.818Kv7.2/Kv7.3 agonist 1
CAS:Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.Formula:C14H14FN3O2Colore e forma:SolidPeso molecolare:275.28Kv7.2/Kv7.3 activator-1
CAS:Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.Formula:C19H22F2N4OColore e forma:SolidPeso molecolare:360.40cis-KV1.3-IN-1
CAS:cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Formula:C23H30N2O4SColore e forma:SolidPeso molecolare:430.56KCC2 Modulator-2
CAS:KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.Formula:C35H45N5O3Colore e forma:SolidPeso molecolare:583.76Kv3 modulator 5
CAS:Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].Formula:C20H20N4O4Colore e forma:SolidPeso molecolare:380.4Kv7.2/Kv7.3 modulator-1
CAS:Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.Formula:C20H21F4N3O3Colore e forma:SolidPeso molecolare:427.393
