Canale del potassio
I canali del potassio sono un gruppo diversificato di proteine di membrana che facilitano il flusso di ioni potassio (K+) attraverso la membrana cellulare. Questi canali svolgono un ruolo cruciale nel mantenimento del potenziale di membrana a riposo, nella regolazione del volume cellulare e nel controllo dell'eccitabilità dei neuroni e delle cellule muscolari. I canali del potassio sono coinvolti in vari processi fisiologici, tra cui la regolazione del ritmo cardiaco, la secrezione di insulina e il rilascio di neurotrasmettitori. La disfunzione dei canali del potassio è legata a condizioni come aritmie, epilessia e ipertensione. Presso CymitQuimica, offriamo una vasta gamma di modulatori dei canali del potassio per supportare la tua ricerca in elettrofisiologia, salute cardiovascolare e neurobiologia.
Trovati 318 prodotti per "Canale del potassio".
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Linaprazan
CAS:Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.Formula:C21H26N4O2Purezza:99.54%Colore e forma:White SolidPeso molecolare:366.4611-deoxy-PGF2a
CAS:11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contractionFormula:C20H34O4Colore e forma:SolidPeso molecolare:338.48Glibornuride
CAS:Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).Formula:C18H26N2O4SPurezza:98.94% - 99.5%Colore e forma:White SolidPeso molecolare:366.48Ref: TM-T15385
1mg71,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg409,00€50mg580,00€100mg803,00€P-1075
CAS:P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.Formula:C12H17N5Purezza:99.85%Colore e forma:SolidPeso molecolare:231.3Ref: TM-T16420
1mg57,00€1mL*10mM (DMSO)90,00€5mg119,00€10mg192,00€25mg349,00€50mg530,00€100mg708,00€200mg964,00€Clobutinol hydrochloride
CAS:Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].Formula:C14H23Cl2NOPurezza:98%Colore e forma:SolidPeso molecolare:292.25MCHR1 antagonist 2
CAS:MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.Formula:C23H21FN2O5Purezza:98.29%Colore e forma:White SolidPeso molecolare:424.42Ref: TM-T11966
2mg43,00€5mg66,00€1mL*10mM (DMSO)80,00€10mg100,00€25mg210,00€50mg334,00€100mg537,00€200mg710,00€CLP257
CAS:CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.Formula:C14H14FN3O2SPurezza:99.5%Colore e forma:Yellow SolidPeso molecolare:307.34C 101248
CAS:C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Formula:C15H12N6OPurezza:99.14% - 99.31%Colore e forma:SolidPeso molecolare:292.3Kv3 modulator 1
CAS:Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.Formula:C20H20N4O4Purezza:99.36%Colore e forma:SolidPeso molecolare:380.4Kv7.2/Kv7.3 activator-1
CAS:Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.Formula:C19H22F2N4OColore e forma:SolidPeso molecolare:360.40cis-KV1.3-IN-1
CAS:cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Formula:C23H30N2O4SColore e forma:SolidPeso molecolare:430.56BMS-986308
CAS:BMS-986308 is a selective, orally active renal outer medullary potassium (ROMK) channel inhibitor. It demonstrates greater selectivity for ROMK over hERG channels and is applicable in heart failure research.Formula:C24H25N7O2Colore e forma:SolidPeso molecolare:443.50Kv7.2/Kv7.3 agonist 1
CAS:Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.Formula:C14H14FN3O2Colore e forma:SolidPeso molecolare:275.28Kv3 modulator 5
CAS:Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].Formula:C20H20N4O4Colore e forma:SolidPeso molecolare:380.4Kv7.2/Kv7.3 modulator-1
CAS:Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.Formula:C20H21F4N3O3Colore e forma:SolidPeso molecolare:427.393Opakalim
CAS:Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.Formula:C18H22F2N4OColore e forma:SolidPeso molecolare:348.39KCC2 Modulator-2
CAS:KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.Formula:C35H45N5O3Colore e forma:SolidPeso molecolare:583.76KV1.3-IN-2
CAS:KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.Formula:C16H23ClN2O4Colore e forma:SolidPeso molecolare:342.818
