Canale del cloruro
I canali del cloruro sono proteine di membrana che controllano il movimento degli ioni cloruro attraverso le membrane cellulari, svolgendo un ruolo vitale nel mantenimento del volume cellulare, dell'eccitabilità elettrica e dell'equilibrio acido-base. La disfunzione dei canali del cloruro è legata a malattie come la fibrosi cistica, l'epilessia e i disturbi renali. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del cloruro per supportare la tua ricerca sul trasporto ionico, l'omeostasi cellulare e i meccanismi delle malattie.
Trovati 53 prodotti per "Canale del cloruro".
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Halothane
CAS:Halothane (Anestan) 可以减弱内皮依赖性舒张作用。Formula:C2HBrClF3Purezza:99.80% - >99.99%Colore e forma:SolidPeso molecolare:197.38Endovion
CAS:Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.Formula:C16H9BrF6N6OPurezza:98.51%Colore e forma:SolidPeso molecolare:495.18T16Ainh-A01
CAS:T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.Formula:C19H20N4O3S2Purezza:97.18% - 98.15%Colore e forma:SolidPeso molecolare:416.52Niflumic acid
CAS:Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.Formula:C13H9F3N2O2Purezza:99.47%Colore e forma:SolidPeso molecolare:282.22DCPIB
CAS:DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFormula:C22H28Cl2O4Purezza:99.79% - 99.87%Colore e forma:SolidPeso molecolare:427.36Ref: TM-T10979
2mg39,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg87,00€25mg177,00€50mg301,00€100mg485,00€200mg690,00€NS1652
CAS:NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.Formula:C15H11F3N2O3Purezza:99.62%Colore e forma:SolidPeso molecolare:324.25Eact
CAS:Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.Formula:C22H24N2O5SPurezza:98.14%Colore e forma:SolidPeso molecolare:428.5Ref: TM-T15192
1mg34,00€2mg48,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg119,00€25mg213,00€50mg356,00€100mg583,00€Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Formula:C10H13NO4S2Purezza:99.16%Colore e forma:SolidPeso molecolare:275.34Flufenamic acid
CAS:Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.Formula:C14H10F3NO2Purezza:98.68%Colore e forma:White SolidPeso molecolare:281.23Afoxolaner
CAS:Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.Formula:C26H17ClF9N3O3Purezza:99.1% - 99.38%Colore e forma:SolidPeso molecolare:625.87D-myo-Inositol-1,4,5,6-tetraphosphate tetrasodium
D-myo-Inositol-1,4,5,6-tetraphosphate tetrasodium (Inositol 1,4,5,6-tetraphosphate tetrasodium) is one of the isomers of inositol oligophosphates. At concentrations of 8-10 μM, it almost completely inhibits calcium-activated chloride channels (chloride channels).Umifoxolaner
CAS:Umifoxolaner is an anti-parasitic agent (veterinary).Formula:C26H16ClF10N3O3Colore e forma:SolidPeso molecolare:643.87Chlorotoxin TFA
Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.Formula:C160H250F3N53O49S11Colore e forma:SolidPeso molecolare:4109.74GaTx2
CAS:High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.Formula:C125H199N39O47S6Purezza:98%Colore e forma:SolidPeso molecolare:3192.54Chlorotoxin(linear)
Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.Formula:C158H256N52O48S11Purezza:98%Colore e forma:SolidPeso molecolare:4004.76Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;Colore e forma:Odour SolidRef: TM-L2300
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaChlorotoxin
CAS:Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.Formula:C158H249N53O47S11Purezza:98%Colore e forma:SolidPeso molecolare:3995.71ANO1-IN-4
CAS:ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.Formula:C19H19BrF2N2O2SColore e forma:SolidPeso molecolare:457.33Lubiprostone hemiketal
CAS:Lubiprostone (hemiketal) (RU-0211 (hemiketal)), a selective activator of the chloride channel 2 (CLCN2), facilitates the treatment of chronic idiopathic constipation and opioid-induced constipation. It functions by enhancing CLCN2 channel activity, which boosts chloride ion secretion in the intestines, subsequently increasing fluid secretion and improving intestinal peristalsis. Additionally, Lubiprostone (hemiketal) may be utilized in research related to chronic constipation and cancer.Formula:C20H32F2O5Colore e forma:SolidPeso molecolare:390.46Afoxolaner (Standard)
CAS:Afoxolaner (Standard) is the standard substance of Afoxolaner, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.Formula:C26H17ClF9N3O3Colore e forma:SolidPeso molecolare:625.87Lubiprostone
CAS:Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.Formula:C20H32F2O5Purezza:97.31% - 98.54%Colore e forma:SolidPeso molecolare:390.46Adjudin
CAS:Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.Formula:C15H12Cl2N4OPurezza:96.51% - ≥95%Colore e forma:SolidPeso molecolare:335.19Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purezza:99.84%Colore e forma:Yellow SolidPeso molecolare:769.96Irisolidone
CAS:Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.Formula:C17H14O6Purezza:99.41% - 99.87%Colore e forma:SolidPeso molecolare:314.29Ref: TM-TN1035
1mg105,00€5mg250,00€1mL*10mM (DMSO)255,00€10mg378,00€25mg618,00€50mg859,00€100mg1.153,00€Fenamic acid
CAS:Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.Formula:C13H11NO2Purezza:99.6%Colore e forma:SolidPeso molecolare:213.2319Anthracene-9-carboxylic acid
CAS:Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.Formula:C15H10O2Purezza:99.05%Colore e forma:SolidPeso molecolare:222.24Phenyl benzoate
CAS:Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid.It is an important organic synthesis intermediate.Formula:C13H10O2Purezza:99.63%Colore e forma:White SolidPeso molecolare:198.22Talniflumate
CAS:Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cellFormula:C21H13F3N2O4Purezza:98% - 99.81%Colore e forma:Yellow SolidPeso molecolare:414.33NPPB
CAS:NPPB is a chloride channel blocker with IC50 of 80 nM .Formula:C16H16N2O4Purezza:99.95%Colore e forma:White SolidPeso molecolare:300.31MONNA
CAS:MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.Formula:C18H14N2O5Purezza:98.29%Colore e forma:SolidPeso molecolare:338.31CaCCinh-A01
CAS:CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).Formula:C18H21NO4SPurezza:99.36% - >99.99%Colore e forma:White SolidPeso molecolare:347.43Org 25543
CAS:Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.Formula:C24H32N2O4Purezza:99.31%Colore e forma:SolidPeso molecolare:412.52Ref: TM-T50082
1mg55,00€5mg114,00€1mL*10mM (DMSO)129,00€10mg170,00€25mg274,00€50mg371,00€100mg522,00€200mg687,00€NS5818
CAS:NS5818 inhibits ClC.Formula:C23H19Cl2N7O2Purezza:98%Colore e forma:SolidPeso molecolare:496.35Bts 39542
CAS:Bts 39542 is a diuretic that plays a major role in the Henle circulation and increases renal blood flow without affecting glomerular filtration rate.Formula:C16H11ClN4O3SColore e forma:SolidPeso molecolare:374.8IAA-94
CAS:IAA-94 is an inhibitor of chloride channels, it binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.Formula:C17H18Cl2O4Colore e forma:SolidPeso molecolare:357.23NS-3736
CAS:NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption.Formula:C15H9BrClF3N6OColore e forma:SolidPeso molecolare:461.62BTG-1640
CAS:BTG-1640 is used potentially for the treatment of anxiety and panic disorder.Formula:C15H19NO2Colore e forma:SolidPeso molecolare:245.32Alilusem
CAS:Alilusem is a new diuretic that is beneficial to the clinical treatment of hypertension.Formula:C17H15ClKN2O5SColore e forma:SolidPeso molecolare:433.92H100
CAS:H100 inhibits Cl- transport, mildly affects NaK2Cl cotransporter and Band 3 anion exchanger, not KCl cotransporter.Formula:C18H16N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:388.4ANO1-IN-2
CAS:ANO1-IN-2: potent ANO1 blocker (IC50: 1.75 μM), less effective on ANO2 (IC50: 7.43 μM), inhibits glioblastoma cell growth.Formula:C16H14ClN3O2S2Colore e forma:SolidPeso molecolare:379.88Stepronin
CAS:Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.Formula:C10H11NO4S2Purezza:99.59%Colore e forma:White SolidPeso molecolare:273.33Ref: TM-T21433
5mg48,00€1mL*10mM (DMSO)48,00€10mg71,00€25mg111,00€50mg187,00€100mg290,00€200mg410,00€Ani9
CAS:Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.Formula:C17H17ClN2O3Purezza:99.73%Colore e forma:White SolidPeso molecolare:332.78Ref: TM-T26630
1mg37,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg124,00€25mg255,00€50mg430,00€100mg620,00€500mg1.333,00€R(+)-IAA-94
CAS:R(+)-IAA-94 (Methylindazone) blocks epithelial chloride channels; inhibits Nef-sdAb19 binding.Formula:C17H18Cl2O4Purezza:98.95% - 99.17%Colore e forma:White SolidPeso molecolare:357.23ANO1-IN-1
CAS:ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.Formula:C18H28N2O2SPurezza:99.93%Colore e forma:SolidPeso molecolare:336.49Losigamone
CAS:Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.Formula:C12H11ClO4Purezza:99.98%Colore e forma:SolidPeso molecolare:254.67OADS
CAS:OADS is an inhibitor of ClC-ec1 with low micromolar affinity. OADS has no specific effect on a CLC channel (ClC-1).Formula:C30H42N2O8S2Colore e forma:SolidPeso molecolare:622.79ARN 11391
CAS:ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ionFormula:C22H29N3O3Colore e forma:SolidPeso molecolare:383.49DIOA
CAS:DIOA acts as a potent antagonist of acid-sensitive outwardly rectifying (ASOR) anion channels [1].Formula:C20H24Cl2O4Colore e forma:SolidPeso molecolare:399.31PAT1inh-B01
CAS:PAT1inh-B01, a selective SLC26A6 inhibitor, impedes PAT1 (a Cl-/HCO3- exchanger) activity, with an IC50 of 350 nM, effectively inhibiting anion exchange.Formula:C22H18BrF3N6O2Colore e forma:SolidPeso molecolare:535.32NMD670
CAS:NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].Formula:C12H10BrNO4Colore e forma:SolidPeso molecolare:312.12
