Canale del cloruro
I canali del cloruro sono proteine di membrana che controllano il movimento degli ioni cloruro attraverso le membrane cellulari, svolgendo un ruolo vitale nel mantenimento del volume cellulare, dell'eccitabilità elettrica e dell'equilibrio acido-base. La disfunzione dei canali del cloruro è legata a malattie come la fibrosi cistica, l'epilessia e i disturbi renali. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del cloruro per supportare la tua ricerca sul trasporto ionico, l'omeostasi cellulare e i meccanismi delle malattie.
Trovati 53 prodotti di "Canale del cloruro"
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Flufenamic acid
CAS:<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Formula:C14H10F3NO2Purezza:98.68%Colore e forma:White To Light Yellow Crystalline PowderPeso molecolare:281.23Endovion
CAS:<p>Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.</p>Formula:C16H9BrF6N6OPurezza:98.51%Colore e forma:SolidPeso molecolare:495.18DCPIB
CAS:<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>Formula:C22H28Cl2O4Purezza:99.79% - 99.87%Colore e forma:SolidPeso molecolare:427.36Afoxolaner
CAS:Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.Formula:C26H17ClF9N3O3Purezza:99.1% - 99.38%Colore e forma:SolidPeso molecolare:625.87Halothane
CAS:Halothane (Anestan) 可以减弱内皮依赖性舒张作用。Formula:C2HBrClF3Purezza:99.80% - >99.99%Colore e forma:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustiblePeso molecolare:197.38NS1652
CAS:<p>NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.</p>Formula:C15H11F3N2O3Purezza:99.62%Colore e forma:SolidPeso molecolare:324.25Niflumic acid
CAS:<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>Formula:C13H9F3N2O2Purezza:99.47%Colore e forma:SolidPeso molecolare:282.22Eact
CAS:<p>Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.</p>Formula:C22H24N2O5SPurezza:98.14%Colore e forma:SolidPeso molecolare:428.5T16Ainh-A01
CAS:T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.Formula:C19H20N4O3S2Purezza:97.18% - 98.15%Colore e forma:SolidPeso molecolare:416.52Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Formula:C10H13NO4S2Purezza:99.16%Colore e forma:SolidPeso molecolare:275.34Chlorotoxin TFA
Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.Formula:C160H250F3N53O49S11Colore e forma:SolidPeso molecolare:4109.74Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Colore e forma:Odour SolidChlorotoxin
CAS:<p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>Formula:C158H249N53O47S11Purezza:98%Colore e forma:SolidPeso molecolare:3995.71Chlorotoxin(linear)
Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.Formula:C158H256N52O48S11Purezza:98%Colore e forma:SolidPeso molecolare:4004.76GaTx2
CAS:High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.Formula:C125H199N39O47S6Purezza:98%Colore e forma:SolidPeso molecolare:3192.54Umifoxolaner
CAS:Umifoxolaner is an anti-parasitic agent (veterinary).Formula:C26H16ClF10N3O3Colore e forma:SolidPeso molecolare:643.87ANO1-IN-4
CAS:ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.Formula:C19H19BrF2N2O2SColore e forma:SolidPeso molecolare:457.33Lubiprostone hemiketal
CAS:Lubiprostone (hemiketal) (RU-0211 (hemiketal)), a selective activator of the chloride channel 2 (CLCN2), facilitates the treatment of chronic idiopathic constipation and opioid-induced constipation. It functions by enhancing CLCN2 channel activity, which boosts chloride ion secretion in the intestines, subsequently increasing fluid secretion and improving intestinal peristalsis. Additionally, Lubiprostone (hemiketal) may be utilized in research related to chronic constipation and cancer.Formula:C20H32F2O5Colore e forma:SolidPeso molecolare:390.46Afoxolaner (Standard)
CAS:Afoxolaner (Standard) is the standard substance of Afoxolaner, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.Formula:C26H17ClF9N3O3Peso molecolare:625.87Irisolidone
CAS:<p>Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.</p>Formula:C17H14O6Purezza:99.41% - 99.87%Colore e forma:SolidPeso molecolare:314.29Fenamic acid
CAS:Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.Formula:C13H11NO2Purezza:99.6%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:213.2319CaCCinh-A01
CAS:CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).Formula:C18H21NO4SPurezza:99.36% - >99.99%Colore e forma:SolidPeso molecolare:347.43Talniflumate
CAS:<p>Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell</p>Formula:C21H13F3N2O4Purezza:98% - 99.81%Colore e forma:White To Pale Yellow Crystalline PowderPeso molecolare:414.33MONNA
CAS:<p>MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.</p>Formula:C18H14N2O5Purezza:98.29%Colore e forma:SolidPeso molecolare:338.31Lubiprostone
CAS:Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.Formula:C20H32F2O5Purezza:97.31% - 98.54%Colore e forma:White Odorless Crystals Or Crystalline PowderPeso molecolare:390.46Guanidinoethyl sulfonate
CAS:Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist.Formula:C3H9N3O3SPurezza:99.43% - 99.47%Colore e forma:SolidPeso molecolare:167.19Adjudin
CAS:Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.Formula:C15H12Cl2N4OPurezza:96.51% - ≥95%Colore e forma:SolidPeso molecolare:335.19NPPB
CAS:NPPB is a chloride channel blocker with IC50 of 80 nM .Formula:C16H16N2O4Purezza:99.95%Colore e forma:Light Yellow To Yellow SolidPeso molecolare:300.31Anthracene-9-carboxylic acid
CAS:Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.Formula:C15H10O2Purezza:99.05%Colore e forma:Yellow Cystalline PowderPeso molecolare:222.24Org 25543
CAS:Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.Formula:C24H32N2O4Purezza:99.13%Colore e forma:SolidPeso molecolare:412.52Phenyl benzoate
CAS:<p>Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid.It is an important organic synthesis intermediate.</p>Formula:C13H10O2Purezza:99.63%Colore e forma:White Crystalline PowderPeso molecolare:198.22Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purezza:99.84%Colore e forma:SolidPeso molecolare:769.96Hydroflumethiazide
CAS:Hydroflumethiazide is a thiazide diuretic. It has also shown the activity of anti-hypertensive.Formula:C8H8F3N3O4S2Colore e forma:Crystals SolidPeso molecolare:331.29Alilusem
CAS:Alilusem is a new diuretic that is beneficial to the clinical treatment of hypertension.Formula:C17H15ClKN2O5SColore e forma:SolidPeso molecolare:433.92H100
CAS:H100 inhibits Cl- transport, mildly affects NaK2Cl cotransporter and Band 3 anion exchanger, not KCl cotransporter.Formula:C18H16N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:388.4NS5818
CAS:NS5818 inhibits ClC.Formula:C23H19Cl2N7O2Purezza:98%Colore e forma:SolidPeso molecolare:496.35ANO1-IN-2
CAS:ANO1-IN-2: potent ANO1 blocker (IC50: 1.75 μM), less effective on ANO2 (IC50: 7.43 μM), inhibits glioblastoma cell growth.Formula:C16H14ClN3O2S2Colore e forma:SolidPeso molecolare:379.88BTG-1640
CAS:BTG-1640 is used potentially for the treatment of anxiety and panic disorder.Formula:C15H19NO2Colore e forma:SolidPeso molecolare:245.32Bts 39542
CAS:Bts 39542 is a diuretic that plays a major role in the Henle circulation and increases renal blood flow without affecting glomerular filtration rate.Formula:C16H11ClN4O3SColore e forma:SolidPeso molecolare:374.8IAA-94
CAS:IAA-94 is an inhibitor of chloride channels, it binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.Formula:C17H18Cl2O4Colore e forma:SolidPeso molecolare:357.23NS-3736
CAS:NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption.Formula:C15H9BrClF3N6OColore e forma:SolidPeso molecolare:461.62Losigamone
CAS:Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.Formula:C12H11ClO4Purezza:99.98%Colore e forma:SolidPeso molecolare:254.67Ani9
CAS:<p>Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.</p>Formula:C17H17ClN2O3Purezza:99.73%Colore e forma:SolidPeso molecolare:332.78ANO1-IN-1
CAS:ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.Formula:C18H28N2O2SPurezza:99.93%Colore e forma:SolidPeso molecolare:336.49Stepronin
CAS:Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.Formula:C10H11NO4S2Purezza:99.59%Colore e forma:White Or Off White CrystallinePeso molecolare:273.33R(+)-IAA-94
CAS:<p>R(+)-IAA-94 (Methylindazone) blocks epithelial chloride channels; inhibits Nef-sdAb19 binding.</p>Formula:C17H18Cl2O4Purezza:98.95% - 99.17%Colore e forma:SolidPeso molecolare:357.23ARN 11391
CAS:<p>ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ion</p>Formula:C22H29N3O3Colore e forma:SolidPeso molecolare:383.49DIOA
CAS:DIOA acts as a potent antagonist of acid-sensitive outwardly rectifying (ASOR) anion channels [1].Formula:C20H24Cl2O4Colore e forma:SolidPeso molecolare:399.31OADS
CAS:OADS is an inhibitor of ClC-ec1 with low micromolar affinity. OADS has no specific effect on a CLC channel (ClC-1).Formula:C30H42N2O8S2Colore e forma:SolidPeso molecolare:622.79DFBTA
DFBTA inhibits ANO1 with IC50 of 24 nM, effectively treating inflammatory pain orally.Formula:C18H10ClF2NO3SColore e forma:SolidPeso molecolare:393.79
