Canale del sodio
I canali del sodio sono proteine di membrana essenziali che permettono il passaggio degli ioni sodio (Na+) attraverso la membrana cellulare, generando e propagando segnali elettrici nei neuroni, nelle cellule muscolari e in altri tessuti eccitabili. Questi canali sono vitali per l'inizio e la conduzione dei potenziali d'azione, rendendoli cruciali in processi come la trasmissione degli impulsi nervosi, la contrazione muscolare e la funzione cardiaca. La disregolazione dei canali del sodio può portare a disturbi neurologici, aritmie e condizioni di dolore cronico. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del sodio per supportare la tua ricerca in neurobiologia, cardiologia e gestione del dolore.
Trovati 219 prodotti di "Canale del sodio"
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VGSCs-IN-1
CAS:VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.Formula:C12H12F3N3OSPurezza:99.88%Colore e forma:SolidPeso molecolare:303.3Funapide
CAS:Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.Formula:C22H14F3NO5Purezza:99.91%Colore e forma:SolidPeso molecolare:429.35Ref: TM-T15358
1mg127,00€5mg305,00€10mg464,00€25mg747,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)335,00€Olisutrigine bromide
CAS:Olisutrigine bromide is a sodium channel blocker used as an analgesic.Formula:C25H35BrN2Colore e forma:SolidPeso molecolare:443.463Lubeluzole dihydrochloride
CAS:Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Formula:C22H27Cl2F2N3O2SColore e forma:SolidPeso molecolare:506.44Olorigliflozin
CAS:Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.Formula:C23H27ClO7Colore e forma:SolidPeso molecolare:450.909(R)-Duloxetine
CAS:(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.Formula:C18H19NOSColore e forma:SolidPeso molecolare:297.42Zilvetrigine
CAS:Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.
Formula:C20H20ClN3O2Colore e forma:SolidPeso molecolare:369.845Quinacainol dihydrochloride
CAS:Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.
Formula:C21H32Cl2N2OColore e forma:SolidPeso molecolare:399.398PF-05661014
CAS:PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.Formula:C17H16N4O3S2Colore e forma:SolidPeso molecolare:388.46N-Depropylpropafenone
CAS:N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.Formula:C18H21NO3Colore e forma:SolidPeso molecolare:299.36LBA-3
CAS:LBA-3, a selective and orally active inhibitor of the sodium-coupled citrate transporter SLC13A5, exhibits an IC50 of 67 nM. This compound effectively reduces triglyceride and total cholesterol levels in both oleic and palmitic acid (OPA)-stimulated AML12 cells and PCN-stimulated primary mouse hepatocytes, as well as in mouse models, without showing detectable toxicity. Additionally, LBA-3 is permeable to the blood-brain barrier [1].Formula:C18H18O5Colore e forma:SolidPeso molecolare:314.33Nav1.7 blocker 1
CAS:Nav1.7 blocker 1 (example 41), an effective Na+ channel (Na v) blocker, exhibits a potent IC50 value of 0.037 μM. This compound is utilized in pain research, encompassing neuropathic, postoperative, and inflammatory pain among others [1].Formula:C22H21FN4O4Peso molecolare:424.42Nav1.8-IN-5
CAS:Nav1.8-IN-5 (Example 1), a voltage-gated sodium channel Nav1.8 inhibitor, is applicable in the research of Nav1.8-mediated diseases including pain, pain-related disorders, and cardiovascular diseases (such as atrial fibrillation) [1].Formula:C23H15F4N3O2Colore e forma:SolidPeso molecolare:441.38ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Formula:C19H13F7N2O2Colore e forma:SolidPeso molecolare:434.307Vormatrigine
CAS:Vormatrigine effectively inhibits sodium channels (sodium channel).Formula:C16H12F6N4O2Colore e forma:SolidPeso molecolare:406.28Suzetrigine
CAS:Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.Formula:C21H20F5N3O4Purezza:98.08% - 99.27%Colore e forma:SolidPeso molecolare:473.39Ref: TM-T69552
1mg58,00€5mg114,00€10mg170,00€25mg266,00€300g129.112,00€50mg457,00€100mg747,00€200mg1.026,00€1mL*10mM (DMSO)118,00€SYM2206
CAS:SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediatedFormula:C20H22N4O3Purezza:99.8%Colore e forma:SolidPeso molecolare:366.41PF-06761281
CAS:PF-06761281 is a partially selective sodium-coupled citrate transporter protein (NaCT/SLC13A5) inhibitor, oral, reducing plasma glucose concentration.Formula:C13H17NO6Colore e forma:SolidPeso molecolare:283.28Oxethazaine
CAS:Prodotto controllatoApplications A potent local anesthetic that is active even in acidic conditions. It is used (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis.
References Detrain, M. et al.: Acta. Gastro-Enterol. Belg., 28, 360 (1965); Barbezat, G.O. et al.: Scand. J. Gastroenterol., 13, 321 (1978); Masuda, Y. et al.: Biochem. Pharmacol., 64, 677 (2002);Formula:C28H41N3O3Colore e forma:NeatPeso molecolare:467.64Ref: TR-O846600
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