Canale del sodio
I canali del sodio sono proteine di membrana essenziali che permettono il passaggio degli ioni sodio (Na+) attraverso la membrana cellulare, generando e propagando segnali elettrici nei neuroni, nelle cellule muscolari e in altri tessuti eccitabili. Questi canali sono vitali per l'inizio e la conduzione dei potenziali d'azione, rendendoli cruciali in processi come la trasmissione degli impulsi nervosi, la contrazione muscolare e la funzione cardiaca. La disregolazione dei canali del sodio può portare a disturbi neurologici, aritmie e condizioni di dolore cronico. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del sodio per supportare la tua ricerca in neurobiologia, cardiologia e gestione del dolore.
Trovati 209 prodotti di "Canale del sodio"
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Nav1.7-IN-18
Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).Formula:C30H33Cl2F2NO4Colore e forma:SolidPeso molecolare:580.49Analgesic agent-2
Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the humanFormula:C21H21ClF2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:434.87ETD001
CAS:ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.Formula:C41H57F6N9O16Colore e forma:SolidPeso molecolare:1045.93Nav1.3 channel inhibitor 1
Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel Na v 1.3, with an IC50 value of 20 nM.Formula:C19H15F2N3O3S2Purezza:98%Colore e forma:SolidPeso molecolare:435.47ASG-5ME
ASG-5ME is a drug-antibody coupling targeting SLC44A4 that shows anti-tumor activity in xenograft models and may be used to study pancreatic and gastric cancer.Purezza:98.1% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.5% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.5 kDaZandatrigine
CAS:Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsyFormula:C22H25FN4O2S2Purezza:99.98%Colore e forma:SolidPeso molecolare:460.59Ref: TM-T39630
1mg117,00€2mg167,00€5mg283,00€10mg464,00€25mg745,00€50mg1.064,00€100mg1.406,00€1mL*10mM (DMSO)310,00€CL-424032
CAS:CL-424032 is an inhibitor of sodium channels (sodium channel).Formula:C12H7F3N4O2Colore e forma:SolidPeso molecolare:296.21Myomodulin
CAS:Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A theFormula:C36H67N11O8S2Purezza:98%Colore e forma:SolidPeso molecolare:846.12Zoniporide
CAS:Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.Formula:C17H16N6OPurezza:99.74%Colore e forma:SolidPeso molecolare:320.351-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.Formula:C6H8N2OPurezza:99.92%Colore e forma:SolidPeso molecolare:124.145-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Formula:C13H28OPurezza:97.87%Colore e forma:SolidPeso molecolare:200.36Benzonatate (PEGn)
CAS:Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.Formula:(C2H4O)nC12H17NO2Colore e forma:SolidNHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Formula:C23H20ClN3O3Colore e forma:SolidPeso molecolare:421.11932APETx2
CAS:ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.Formula:C196H280N54O61S6Purezza:98%Colore e forma:SolidPeso molecolare:4561.06Mambalgin 1
CAS:ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.Formula:C272H429N85O84S10Purezza:98%Colore e forma:SolidPeso molecolare:6554.51ProTx II
CAS:<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Formula:C168H250N46O41S8Purezza:98%Colore e forma:SolidPeso molecolare:3826.59Batrachotoxin
CAS:Batrachotoxin (BTX), a potent neurotoxin and cardiotoxin, is found in the skin of the Colombian dart frog (Phyllobates aurotaenia). As an activator of sodium channels (sodium channel), it interferes with normal sodium channel closure by binding to voltage-gated sodium channels (sodium channel) on the cell membrane. This interaction causes a continuous influx of sodium ions into the cells, leading to persistent depolarization.Formula:C31H42N2O6Peso molecolare:538.67Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Colore e forma:Odour SolidHuwentoxin-IV
CAS:Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.Formula:C174H278N52O51S6Purezza:98%Colore e forma:SolidPeso molecolare:4106.79Amlenetug
Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidOD1
Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.Formula:C308H466N90O95S8Purezza:98%Colore e forma:SolidPeso molecolare:7206.1Phrixotoxin 3
CAS:Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.Formula:C176H269N51O48S6Purezza:98%Colore e forma:SolidPeso molecolare:4059.74PF-06456384 trihydrochloride
CAS:PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.Formula:C35H35Cl3F3N7O3S2Purezza:99.16%Colore e forma:SolidPeso molecolare:829.18Indenebart
Indenebart is a humanized IgG1λ2 monoclonal antibody targeting SNCA, with HumanIgG1lambda2, Isotype Control serving as the corresponding isotype control.Colore e forma:Odour LiquidSodium Channel Targeted Library
A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;Colore e forma:Odour SolidRef: TM-L7400
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaLifarizine FA
Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.Formula:C30H34N4O2Purezza:99.55%Colore e forma:SolidPeso molecolare:482.62Anthopleurin-A
CAS:Anthopleurin-A, a sodium channel toxin, is selective for cardiac channels and has a cardiotonic effect. It can be isolated from the sea anemone [1] [2].Formula:C220H326N64O67S6Peso molecolare:5131.72GX 201
CAS:GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.Formula:C25H27ClF4N2O4SPurezza:99.81%Colore e forma:SolidPeso molecolare:563Mepivacaine hydrochloride
CAS:Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.Formula:C15H22N2O·HClPurezza:98.76% - 99.94%Colore e forma:White Or Off White Crystalline PowderPeso molecolare:282.81Trapencaine
CAS:Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.Formula:C22H34N2O3Purezza:97.68%Colore e forma:SolidPeso molecolare:374.52Mexiletine-d6 hydrochloride
CAS:Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.Formula:C11H18ClNOPurezza:98%Colore e forma:SolidPeso molecolare:221.76Triamterene D5
CAS:Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.Formula:C12H11N7Purezza:98%Colore e forma:SolidPeso molecolare:258.29BI-9627
CAS:BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) (EC50: 31 nM).Formula:C16H19F3N4O2Purezza:99.77%Colore e forma:SolidPeso molecolare:356.34Ethacizine hydrochloride
CAS:Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity and can be used to study arrhythmias and myocardial infarction.Formula:C22H28ClN3O3SPurezza:98.08% - 98.08%Colore e forma:SolidPeso molecolare:449.99Mepivacaine
CAS:Mepivacaine (Carbocaine) is an amide local anesthetic, blocking sodium channels for nerve blocks and epidurals.Formula:C15H22N2OPurezza:99.86%Colore e forma:SolidPeso molecolare:246.3510,11-Dihydro-10-hydroxycarbamazepine-d4
CAS:10,11-Dihydro-10-hydroxycarbamazepine-d4 is a deuterated compound of 10,11-Dihydro-10-hydroxycarbamazepine.Formula:C15H10D4N2O2Peso molecolare:258.31PF-04856264
CAS:PF-04856264 is a Nav1.7 blocker.,modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain analgesic.Formula:C20H15N5O3S2Purezza:97.43%Colore e forma:SolidPeso molecolare:437.5Ref: TM-T33943
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg562,00€100mg944,00€1mL*10mM (DMSO)124,00€Bulleyaconitine A
CAS:Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.Formula:C35H49NO9Purezza:99.56% - 99.76%Colore e forma:SolidPeso molecolare:627.76Poneratoxin acetate
<p>Poneratoxin acetate is a neurotoxic peptide and modulator of NaV1.6/NaV1.7, lowering the activation threshold of voltage-gated sodium channels and causing pain.</p>Formula:C129H215N33O31S·xC2H4O2Colore e forma:SolidPeso molecolare:2756.35 (free base)Dibucaine hydrochloride
CAS:<p>Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.</p>Formula:C20H30ClN3O2Purezza:99.66%Colore e forma:White PowderPeso molecolare:379.92AM-2099
CAS:AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.Formula:C19H13F3N4O3S2Colore e forma:SolidPeso molecolare:466.46Raxatrigine
CAS:Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.Formula:C18H19FN2O2Purezza:98% - 99.43%Colore e forma:SolidPeso molecolare:314.35DS-1971a
CAS:DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.Formula:C20H21ClFN5O3SPurezza:99.66%Colore e forma:SolidPeso molecolare:465.93Ref: TM-T9685
1mg66,00€2mgPrezzo su richiesta5mg144,00€10mg216,00€25mg354,00€50mg502,00€1mL*10mM (DMSO)149,00€A-803467
CAS:A-803467 is a selective NaV1.8 channel blocker.Formula:C19H16ClNO4Purezza:96.94% - 98%Colore e forma:SolidPeso molecolare:357.79Flecainide hydrochloride
CAS:Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.Formula:C17H21ClF6N2O3Purezza:97.79%Colore e forma:SolidPeso molecolare:450.81Ropivacaine hydrochloride monohydrate
CAS:Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.Formula:C17H29ClN2O2Purezza:99.94% - 99.95%Colore e forma:White SolidPeso molecolare:328.88Fosphenytoin disodium
CAS:Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blockerFormula:C16H13N2Na2O6PPurezza:99.97%Colore e forma:White Crystalline PowderPeso molecolare:406.24Metergoline
CAS:Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.Formula:C25H29N3O2Purezza:99.83% - 99.97%Colore e forma:SolidPeso molecolare:403.52Rimeporide
CAS:Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.Formula:C11H15N3O5S2Purezza:97.66%Colore e forma:SolidPeso molecolare:333.38Ref: TM-T5319
1mg48,00€2mg65,00€5mg96,00€10mg170,00€25mg378,00€50mg552,00€100mg787,00€1mL*10mM (DMSO)114,00€λ-Cyhalothrin
CAS:λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.Formula:C23H19ClF3NO3Purezza:99.76%Colore e forma:SolidPeso molecolare:449.85
