Canale del sodio
I canali del sodio sono proteine di membrana essenziali che permettono il passaggio degli ioni sodio (Na+) attraverso la membrana cellulare, generando e propagando segnali elettrici nei neuroni, nelle cellule muscolari e in altri tessuti eccitabili. Questi canali sono vitali per l'inizio e la conduzione dei potenziali d'azione, rendendoli cruciali in processi come la trasmissione degli impulsi nervosi, la contrazione muscolare e la funzione cardiaca. La disregolazione dei canali del sodio può portare a disturbi neurologici, aritmie e condizioni di dolore cronico. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del sodio per supportare la tua ricerca in neurobiologia, cardiologia e gestione del dolore.
Trovati 367 prodotti per "Canale del sodio".
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Phlo1b
Phlo1b (μ-TrTx-Phlo1b), a 35-amino acid peptide toxin, selectively inhibits Nav1.7 channels with minimal inhibition of Nav1.2 and Nav1.5 [1].Formula:C181H260N52O49S6Purezza:98%Colore e forma:SolidPeso molecolare:4140.71GpTx-1 TFA
GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.Colore e forma:Odour SolidCeratotoxin-1
Ceratotoxin-1 (CcoTx1) is a peptide toxin that functions as an inhibitor of various voltage-gated sodium channel subtypes.Formula:C172H256N52O50S6Purezza:98%Colore e forma:SolidPeso molecolare:4044.58μ-TRTX-Hd1a
μ-TRTX-Hd1a, a spider venom-derived compound, selectively inhibits the human NaV 1.7 channel by functioning as a gating modifier.Formula:C160H246N46O51S6Purezza:98%Colore e forma:SolidPeso molecolare:3822.33Jingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neuronsFormula:C154H219N39O45S7Purezza:98%Colore e forma:SolidPeso molecolare:3561.085-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Formula:C13H28OPurezza:97.87%Colore e forma:SolidPeso molecolare:200.36Lifarizine FA
Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.Formula:C30H34N4O2Purezza:99.55%Colore e forma:SolidPeso molecolare:482.62Scorpion toxin Tf2
Scorpion toxin Tf2, a β-scorpion toxin first identified in the venom of the Brazilian scorpion Tityus fasciolatus, acts as an activator of the neuronal voltage-Formula:C309H438N80O87S9Purezza:98%Colore e forma:SolidPeso molecolare:6953.86δ-Buthitoxin-Hj1a
δ-Buthitoxin-Hj1a, a scorpion-venom peptide, functions as a potent agonist for the NaV1.1 channel, exhibiting an EC50 value of 17 nM.Formula:C326H482N92O96S8Purezza:98%Colore e forma:SolidPeso molecolare:7482.39Jingzhaotoxin XI
Jingzhaotoxin XI (JZTX-XI) is a potent inhibitor of sodium conductance, exhibiting an IC50 value of 124 nM, and notably retards the rapid inactivation of Na_v1.Formula:C158H234N44O47S7Purezza:98%Colore e forma:SolidPeso molecolare:3726.27Phrixotoxin 3
CAS:Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.Formula:C176H269N51O48S6Purezza:98%Colore e forma:SolidPeso molecolare:4059.74OD1
Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.Formula:C308H466N90O95S8Purezza:98%Colore e forma:SolidPeso molecolare:7206.1Huwentoxin-IV
CAS:Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.Formula:C174H278N52O51S6Purezza:98%Colore e forma:SolidPeso molecolare:4106.79m3-Huwentoxin IV
m3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6Formula:C170H271N53O46S6Purezza:98%Colore e forma:SolidPeso molecolare:3985.69Solpecainol
CAS:solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.Formula:C18H23NO3Purezza:99.71%Colore e forma:White OilPeso molecolare:301.38SLC26A3-IN-2
CAS:Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.Formula:C19H13ClN2O2SPurezza:99.86%Colore e forma:White SolidPeso molecolare:368.84Anthopleurin-A
CAS:Anthopleurin-A, a sodium channel toxin, is selective for cardiac channels and has a cardiotonic effect. It can be isolated from the sea anemone [1] [2].Formula:C220H326N64O67S6Colore e forma:SolidPeso molecolare:5131.72Hainantoxin-III
CAS:Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting bothFormula:C154H228N44O45S6Purezza:98%Colore e forma:SolidPeso molecolare:3608.12LTGO-33
CAS:LTGO-33 is a voltage-gated sodium channel NaV1.8 inhibitor that inhibits NaV1.8, NaV1.1-NaV1.7, and NaV1.9.Formula:C21H17F4N3O3SPurezza:97.6%Colore e forma:White SolidPeso molecolare:467.44PF-06456384 trihydrochloride
CAS:PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.Formula:C35H35Cl3F3N7O3S2Purezza:99.16%Colore e forma:White SolidPeso molecolare:829.18
