Canale del calcio
I canali del calcio sono proteine di membrana che regolano il flusso di ioni calcio dentro e fuori dalle cellule, essenziale per varie funzioni cellulari, tra cui la contrazione muscolare, il rilascio di neurotrasmettitori e l'espressione genica. La disfunzione dell'attività dei canali del calcio è associata a condizioni come ipertensione, aritmie cardiache e disturbi neurologici. Presso CymitQuimica, offriamo un'ampia selezione di modulatori dei canali del calcio per supportare la tua ricerca in salute cardiovascolare, neurobiologia e trasduzione del segnale.
Trovati 541 prodotti di "Canale del calcio"
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MONIRO-1
CAS:MONIRO-1 blocks T/N-type Ca²⁺ channels: hCav2.2 (IC50: 34μM), hCav3.1 (3.3μM), hCav3.2 (1.7μM), hCav3.3 (7.2μM).Formula:C23H24ClFN4O3Colore e forma:SolidPeso molecolare:458.92TMDJ-035
CAS:TMDJ-035 is a selective inhibitor of the RyR2 (ryanodine receptor 2).Formula:C16H12F3N5OPurezza:98%Colore e forma:SolidPeso molecolare:347.29BBT
CAS:BBT has anti-hyperglycemic activity, protecting beta cells from cytokine or streptozotocin-induced cell death, and restoring beta cell function.Formula:C18H12BrNO2SPurezza:99.02%Colore e forma:SolidPeso molecolare:386.268-bromo NAD+ sodium
CAS:8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38.Formula:C21H25BrN7O14P2·NaColore e forma:SolidPeso molecolare:764.30Fluspirilene
CAS:Fluspirilene is a long-acting antipsychotic for schizophrenia, inhibiting L-type calcium channels (IC50: 0.03 μM).Formula:C29H31F2N3OPurezza:99.59%Colore e forma:SolidPeso molecolare:475.57Reldesemtiv
CAS:<p>Reldesemtiv (CK-2127107) boosts exercise capacity, targeting fast muscle troponin, EC50 3.4 μM.</p>Formula:C19H18F2N6OPurezza:97.27%Colore e forma:SolidPeso molecolare:384.38AY 77
CAS:<p>AY 77: Potent, selective PAR2 agonist, favors Ca2+ (ec50=40nM) & ERK1/2 (ec50=2μM), boosts breast cancer cell migration.</p>Formula:C21H32N4O4Purezza:99.7%Colore e forma:SolidPeso molecolare:404.5Bupivacaine hydrochloride monohydrate
CAS:Bupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor that inhibits SCN5A channels and is commonly used in the study of chronic pain.Formula:C18H31ClN2O2Purezza:99.91%Colore e forma:SolidPeso molecolare:342.9Cis-22a
CAS:Cis-22a: selective TRPV6 inhibitor (IC50=0.32μM), halts T47D breast cancer cell growth.Formula:C24H30F3N3O2Purezza:99.99%Colore e forma:SolidPeso molecolare:449.51EMD57033
CAS:EMD57033 activates cardiac troponin C, enhances Ca2+ sensitivity to boost heart contraction.Formula:C22H23N3O4SPurezza:97.24% - 99.11%Colore e forma:SolidPeso molecolare:425.5Calcium channel-modulator-1
CAS:<p>Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.</p>Formula:C26H24Cl2N2O7SPurezza:99.95%Colore e forma:SolidPeso molecolare:579.45PDE1-IN-4
PDE1-IN-4: inhibits PDE1C/A/B with IC50s 10/145/354 nM, may help study idiopathic pulmonary fibrosis.Formula:C33H33N3O4Colore e forma:SolidPeso molecolare:535.63NNC 55-0396
CAS:NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.Formula:C30H40Cl2FN3O2Purezza:99.00%Colore e forma:SolidPeso molecolare:564.56Ref: TM-T12238
1mg66,00€5mg126,00€10mg202,00€25mg354,00€50mg550,00€100mg787,00€1mL*10mM (DMSO)160,00€Sesamodil
CAS:<p>Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.</p>Formula:C29H32N2O6SPurezza:98.58% - 99.01%Colore e forma:SolidPeso molecolare:536.64Cav 3.2 inhibitor 1
Cav 3.2 inhibitor 1 targets T-type calcium channels, weakly binds D2 receptors, and aids physical and visceral pain research.Formula:C32H39N3OColore e forma:SolidPeso molecolare:481.67Calpain Inhibitor-2
CAS:Calpain Inhibitor-2: Lipophilic, moderates growth of A-375, B-16F1, PC-3 cancers, and hinders 80% DU-145 cell invasion.Formula:C26H33N3O5SColore e forma:SolidPeso molecolare:499.62Cav 3.2 inhibitor 3
Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.Formula:C32H37N3O2Colore e forma:SolidPeso molecolare:495.66AZD 2066 hydrate
AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].Formula:C19H18ClN5O3Colore e forma:SolidPeso molecolare:386.33PD-217014
CAS:PD-217014 is an α2δ ligand that exhibits visceral analgesic activity and can suppress visceral hypersensitivity. Its antihyperalgesic effects are dose-dependent.Formula:C10H17NO2Colore e forma:SolidPeso molecolare:183.25SR 33805 oxalate
CAS:Ca2+ channel antagonistFormula:C34H42N2O9SPurezza:98%Colore e forma:SolidPeso molecolare:654.77IAB15
CAS:IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].Formula:C15H14F3NO2Colore e forma:SolidPeso molecolare:297.27IAA65
CAS:IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].Formula:C16H13F6NO2Colore e forma:SolidPeso molecolare:365.27Cav 3.1 blocker 1
CAS:Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel inhibitor with an IC50 value of 160 nM for Cav3.1. It exhibits weaker inhibition on Cav 3.2 with an IC50 of 5000 nM and shows no inhibitory effect on Cav 3.3 and Cav 1.2 (IC50 > 10000 nM).Formula:C26H19F6N3O2Peso molecolare:519.438Mibefradil dihydrochloride hydrate
CAS:Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.Formula:C29H42Cl2FN3O4Colore e forma:SolidPeso molecolare:586.57Cav 2.2/3.2 blocker 1
Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.Formula:C28H30N2O3Colore e forma:SolidPeso molecolare:442.55SB-423557
CAS:SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nMFormula:C28H36N2O4Purezza:98%Colore e forma:SolidPeso molecolare:464.60(rel)-Mirogabalin
CAS:(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.Formula:C12H19NO2Colore e forma:SolidPeso molecolare:209.28Mibefradil
CAS:Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).Formula:C29H38FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:495.63Cav 3.2 inhibitor 2
Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.Formula:C32H37F2N3OColore e forma:SolidPeso molecolare:517.65T-Type calcium channel inhibitor 2
Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).Formula:C36H39FN4OSColore e forma:SolidPeso molecolare:594.78TTA-P1
CAS:TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.Formula:C19H27Cl2FN2OColore e forma:SolidPeso molecolare:389.33BER-5
CAS:BER-5 is a potent MrgX2 antagonist, demonstrating broad-spectrum antagonistic activity against various MrgX2 agonists. It can inhibit Substance P(SP)-induced degranulation in LAD2 cells and alleviate SP-induced allergic reactions in mice. BER-5 is useful for researching mechanisms related to allergic reactions.Formula:C20H16O4Colore e forma:SolidPeso molecolare:320.34Emopamil
CAS:Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.Formula:C23H30N2Colore e forma:SolidPeso molecolare:334.5CAD204520
CAS:CAD204520 functions as an inhibitor of SERCA (IC50 = 0.34 μM), specifically targeting mutations in the wild-type NOTCH1 protein associated with T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).Formula:C23H32F3N3O2Colore e forma:SolidPeso molecolare:439.51RWJ 22108
CAS:RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.Formula:C27H30ClFN2O4SColore e forma:SolidPeso molecolare:533.06CCR4 antagonist 2
CAS:CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits TregFormula:C26H28Cl2N6OPurezza:98%Colore e forma:SolidPeso molecolare:511.45Leualacin
CAS:Leualacin is a novel calcium blocker from Hapsidospora irregularis.Formula:C31H47N3O7Purezza:98%Colore e forma:SolidPeso molecolare:573.72MP-010
CAS:<p>MP-010 is an FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. It facilitates functional improvement in SOD1G93A mice with amyotrophic lateral sclerosis (ALS), evidenced by enhanced motor coordination, increased integrity of neuromuscular junctions, and significantly higher spinal motor neuron survival rates. MP-010 is applicable for research in the field of neurological disorders.</p>Formula:C14H20N4O2SColore e forma:SolidPeso molecolare:308.399Verapamil EP Impurity C hydrochloride
CAS:NSC-609249 hydrochloride, an impurity of Verapamil, is a calcium channel blocker with potent orally active properties. It also functions as a first-generation P-glycoprotein (P-gp) inhibitor.Formula:C12H20ClNO2Colore e forma:SolidPeso molecolare:245.75(Rac)-PD0299685
CAS:<p>(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.</p>Formula:C10H21NO2Purezza:97.20%Colore e forma:SolidPeso molecolare:187.28Fostedil
CAS:Fostedil enhances heart function, maintains blood flow during partial/total coronary occlusions, and lowers aortic pressure.Formula:C18H20NO3PSPurezza:98%Colore e forma:SolidPeso molecolare:361.4Ref: TM-T27351
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