PDE
Le fosfodiesterasi (PDEs) sono enzimi che idrolizzano i nucleotidi ciclici, come cAMP e cGMP, nelle loro forme inattive, svolgendo un ruolo chiave nella regolazione delle vie di segnalazione intracellulare. Gli inibitori delle PDE sono utilizzati nel trattamento di varie condizioni, tra cui malattie cardiovascolari, disfunzione erettile e disturbi respiratori, grazie alla loro capacità di modulare i livelli di nucleotidi ciclici. Presso CymitQuimica, offriamo una gamma di inibitori delle PDE per supportare la tua ricerca nella segnalazione cellulare, farmacologia e sviluppo terapeutico.
Trovati 166 prodotti di "PDE"
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Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Formula:C40H37N5OPurezza:99.4%Colore e forma:SolidPeso molecolare:603.75ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Formula:C22H19N3O4Purezza:98%Colore e forma:SolidPeso molecolare:389.4BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Formula:C15H12ClF3N4OColore e forma:SolidPeso molecolare:356.73Tilivapram
CAS:Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.Formula:C16H15Cl2N3O4Purezza:99.87%Colore e forma:SolidPeso molecolare:384.21Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C32H40ClF3N6O6S2Purezza:98%Colore e forma:SolidPeso molecolare:761.28WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Formula:C23H28N4O4Purezza:99.67%Colore e forma:SolidPeso molecolare:424.49PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Formula:C14H11ClN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:322.77ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Formula:C22H18ClF3N6OPurezza:99.73%Colore e forma:SolidPeso molecolare:474.87Imazodan hydrochloride
CAS:<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Formula:C13H13ClN4OPurezza:98.97%Colore e forma:SolidPeso molecolare:276.72Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Formula:C13H12N4OPurezza:98% - 98.31%Colore e forma:SolidPeso molecolare:240.26PAT-048
CAS:<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Formula:C22H18ClF2N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:461.91Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Formula:C15H22N4O3Purezza:99.76% - 99.86%Colore e forma:Off-White SolidPeso molecolare:306.36PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Formula:C17H23FN6O2Purezza:99.86%Colore e forma:SolidPeso molecolare:362.4PF-04822163
CAS:<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Formula:C19H17ClN2O2Purezza:99.55%Colore e forma:SolidPeso molecolare:340.8Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Formula:C21H23N7O2Purezza:98%Colore e forma:SolidPeso molecolare:405.45(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Formula:C15H20N4O3Colore e forma:SolidPeso molecolare:304.34Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Formula:C15H15ClN4OPurezza:99.93%Colore e forma:SolidPeso molecolare:302.76Lirimilast
CAS:Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.Formula:C17H12Cl2N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:443.26Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C30H39ClN6O4S2Purezza:98%Colore e forma:SolidPeso molecolare:647.25KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Formula:C25H35N7O6SPurezza:99.55%Colore e forma:SolidPeso molecolare:561.65AN3199
CAS:AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.Formula:C17H18BNO5Purezza:99.45%Colore e forma:SolidPeso molecolare:327.14K134
CAS:<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Formula:C22H29N3O4Purezza:98%Colore e forma:SolidPeso molecolare:399.48AWD 12-281
CAS:<p>AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).</p>Formula:C22H14Cl2FN3O3Purezza:99.25% - 99.85%Colore e forma:SolidPeso molecolare:458.27Carbazeran
CAS:<p>Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.</p>Formula:C18H24N4O4Purezza:99.3%Colore e forma:SolidPeso molecolare:360.41Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Formula:C18H21N5SPurezza:99.55%Colore e forma:SolidPeso molecolare:339.46Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFormula:C19H31N7O4Purezza:99.31% - 99.78%Colore e forma:SolidPeso molecolare:421.49Dasantafil
CAS:Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.Formula:C22H28BrN5O5Purezza:99.4% - 99.50%Colore e forma:SolidPeso molecolare:522.39Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Formula:C24H28N2O6SPurezza:98.75% - 99.62%Colore e forma:SolidPeso molecolare:472.55Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFormula:C12H18N4O2Purezza:98.4% - 99.8%Colore e forma:SolidPeso molecolare:250.3Isomazole
CAS:<p>Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.</p>Formula:C14H13N3O2SPurezza:98.66%Colore e forma:SolidPeso molecolare:287.34PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFormula:C20H23ClN4O2Purezza:99.79%Colore e forma:SolidPeso molecolare:386.88PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Formula:C19H18ClN3O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:387.88uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Formula:C26H24F3N3O4Purezza:99.90%Colore e forma:SolidPeso molecolare:499.48Autotaxin-IN-3
CAS:<p>Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.</p>Formula:C22H21N9O2Purezza:99.54% - 99.79%Colore e forma:SolidPeso molecolare:443.46PF-04447943
CAS:<p>PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.</p>Formula:C20H25N7O2Purezza:99.36% - 99.59%Colore e forma:SolidPeso molecolare:395.46Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Formula:C15H20N2O4Purezza:98.93% - 99.99%Colore e forma:SolidPeso molecolare:292.33MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Formula:C25H18N4O3Purezza:99.14%Colore e forma:SolidPeso molecolare:422.44Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Formula:C15H15N3OPurezza:99.96%Colore e forma:SolidPeso molecolare:253.3PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Formula:C14H15F3N8OSPurezza:99.02%Colore e forma:SolidPeso molecolare:400.38PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Formula:C25H21N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:491.52Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Formula:C23H24F2N2O5Purezza:99.47% - 99.64%Colore e forma:SolidPeso molecolare:446.44MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Formula:C19H22N6OSPurezza:99.38% - 99.67%Colore e forma:SolidPeso molecolare:382.48GSK356278
CAS:<p>GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.</p>Formula:C21H25N7O2SPurezza:99.90% - 99.97%Colore e forma:SolidPeso molecolare:439.53Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C30H29N9O2Purezza:98%Colore e forma:SolidPeso molecolare:547.61Adibendan
CAS:<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Formula:C16H14N4OPurezza:99.52% - >99.99%Colore e forma:SolidPeso molecolare:278.31Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Formula:C14H16N6OPurezza:99.62% - 99.87%Colore e forma:SolidPeso molecolare:284.32Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C22H21N9O2Purezza:98%Colore e forma:SolidPeso molecolare:443.46CI-1044
CAS:<p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>Formula:C23H19N5O2Colore e forma:SolidPeso molecolare:397.43BIO-32546
CAS:<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Formula:C28H31F6NO3Purezza:98.03%Colore e forma:SolidPeso molecolare:543.54Gisadenafil besylate
CAS:Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.Formula:C29H39N7O8S2Colore e forma:SolidPeso molecolare:677.79Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Formula:C23H33N7O5SPurezza:98.82% - 99.50%Colore e forma:SolidPeso molecolare:519.62PDE9-IN-(S)-C33
CAS:<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Formula:C18H20ClN5OPurezza:98.75%Colore e forma:SolidPeso molecolare:357.84TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Formula:C26H19F3N4OPurezza:99.21%Colore e forma:SolidPeso molecolare:460.45AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Formula:C25H23N5O3Purezza:99.87%Colore e forma:SolidPeso molecolare:441.48Enpp-1-IN-16
CAS:Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.Formula:C23H32N4O4Purezza:99.87%Colore e forma:SolidPeso molecolare:428.52Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Formula:C21H15Cl2F2N3O2SPurezza:99.9%Colore e forma:SolidPeso molecolare:482.33TPN171
CAS:<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Formula:C24H35N5O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:441.57NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formula:C24H26N2O5Colore e forma:SolidPeso molecolare:422.47PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Formula:C20H28N8O4SPurezza:99.97%Colore e forma:SolidPeso molecolare:476.55Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Formula:C30H40Cl2N6O4S2Purezza:98%Colore e forma:SolidPeso molecolare:683.71TAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Formula:C19H18F4N4O5Purezza:98%Colore e forma:SolidPeso molecolare:458.36BMS-341400 mesylate
CAS:BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.Formula:C24H26ClN9O5SColore e forma:SolidPeso molecolare:588.039Thioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Formula:C24H29ClN6OSPurezza:99.81%Colore e forma:SolidPeso molecolare:485.05Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Formula:C12H14ClN3O3Colore e forma:SolidPeso molecolare:283.71ASP9831
CAS:<p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>Formula:C20H23N3O3Colore e forma:SolidPeso molecolare:353.42Tovinontrine
CAS:Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.Formula:C21H26N6O2Purezza:98.8%Colore e forma:SolidPeso molecolare:394.47
