PDE
Le fosfodiesterasi (PDEs) sono enzimi che idrolizzano i nucleotidi ciclici, come cAMP e cGMP, nelle loro forme inattive, svolgendo un ruolo chiave nella regolazione delle vie di segnalazione intracellulare. Gli inibitori delle PDE sono utilizzati nel trattamento di varie condizioni, tra cui malattie cardiovascolari, disfunzione erettile e disturbi respiratori, grazie alla loro capacità di modulare i livelli di nucleotidi ciclici. Presso CymitQuimica, offriamo una gamma di inibitori delle PDE per supportare la tua ricerca nella segnalazione cellulare, farmacologia e sviluppo terapeutico.
Trovati 166 prodotti di "PDE"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Formula:C23H24F2N2O5Purezza:99.47% - 99.64%Colore e forma:SolidPeso molecolare:446.44MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Formula:C19H22N6OSPurezza:99.38% - 99.67%Colore e forma:SolidPeso molecolare:382.48GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Formula:C21H25N7O2SPurezza:99.90% - 99.97%Colore e forma:SolidPeso molecolare:439.53Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C30H29N9O2Purezza:98%Colore e forma:SolidPeso molecolare:547.61Adibendan
CAS:<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Formula:C16H14N4OPurezza:99.52% - >99.99%Colore e forma:SolidPeso molecolare:278.31Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Formula:C14H16N6OPurezza:99.62% - 99.87%Colore e forma:SolidPeso molecolare:284.32Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C22H21N9O2Purezza:98%Colore e forma:SolidPeso molecolare:443.46CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Formula:C23H19N5O2Colore e forma:SolidPeso molecolare:397.43BIO-32546
CAS:<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Formula:C28H31F6NO3Purezza:98.03%Colore e forma:SolidPeso molecolare:543.54Gisadenafil besylate
CAS:Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.Formula:C29H39N7O8S2Colore e forma:SolidPeso molecolare:677.79Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Formula:C23H33N7O5SPurezza:98.82% - 99.50%Colore e forma:SolidPeso molecolare:519.62PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Formula:C18H20ClN5OPurezza:98.75%Colore e forma:SolidPeso molecolare:357.84TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Formula:C26H19F3N4OPurezza:99.21%Colore e forma:SolidPeso molecolare:460.45AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Formula:C25H23N5O3Purezza:99.87%Colore e forma:SolidPeso molecolare:441.48Enpp-1-IN-16
CAS:Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.Formula:C23H32N4O4Purezza:99.87%Colore e forma:SolidPeso molecolare:428.52Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Formula:C21H15Cl2F2N3O2SPurezza:99.9%Colore e forma:SolidPeso molecolare:482.33TPN171
CAS:<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Formula:C24H35N5O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:441.57NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formula:C24H26N2O5Colore e forma:SolidPeso molecolare:422.47PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Formula:C20H28N8O4SPurezza:99.97%Colore e forma:SolidPeso molecolare:476.55Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Formula:C30H40Cl2N6O4S2Purezza:98%Colore e forma:SolidPeso molecolare:683.71
