PDE
Le fosfodiesterasi (PDEs) sono enzimi che idrolizzano i nucleotidi ciclici, come cAMP e cGMP, nelle loro forme inattive, svolgendo un ruolo chiave nella regolazione delle vie di segnalazione intracellulare. Gli inibitori delle PDE sono utilizzati nel trattamento di varie condizioni, tra cui malattie cardiovascolari, disfunzione erettile e disturbi respiratori, grazie alla loro capacità di modulare i livelli di nucleotidi ciclici. Presso CymitQuimica, offriamo una gamma di inibitori delle PDE per supportare la tua ricerca nella segnalazione cellulare, farmacologia e sviluppo terapeutico.
Trovati 166 prodotti di "PDE"
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K-Ras-PDEδ-IN-1
CAS:<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>Formula:C25H26FN5O2Purezza:99.48%Colore e forma:SolidPeso molecolare:447.5PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Formula:C22H21Cl2N3O5Purezza:98.70% - 99.25%Colore e forma:SolidPeso molecolare:478.33PQ-10
CAS:<p>PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.</p>Formula:C22H21N5O3Purezza:99.86%Colore e forma:SolidPeso molecolare:403.43Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Formula:C17H14Cl2F2N2O4Purezza:98.19% - 99.69%Colore e forma:SolidPeso molecolare:419.21Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Formula:C23H17FN6O2Purezza:98% - 99.79%Colore e forma:SolidPeso molecolare:428.42Irsogladine
CAS:<p>Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.</p>Formula:C9H7Cl2N5Purezza:99.74% - 99.91%Colore e forma:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterPeso molecolare:256.09THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Formula:C23H21ClN6O3Purezza:99.46%Colore e forma:SolidPeso molecolare:464.9Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Formula:C20H25NO4Purezza:97.37% - 99.52%Colore e forma:White SolidPeso molecolare:343.42ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Formula:C9H13N5OPurezza:99.70%Colore e forma:White SolidPeso molecolare:207.23IBMX
CAS:<p>IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM</p>Formula:C10H14N4O2Purezza:98% - >99.99%Colore e forma:Off-WhitePeso molecolare:222.242,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Formula:C9H9Cl2F2NO3SPurezza:98.60%Colore e forma:SolidPeso molecolare:320.14Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFormula:C14H10N4OPurezza:99.68%Colore e forma:SolidPeso molecolare:250.26HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Formula:C24H19BFNO5SPurezza:98.26% - ≥95%Colore e forma:SolidPeso molecolare:463.29Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Formula:C15H22N2O3Purezza:98.82% - 99.79%Colore e forma:SolidPeso molecolare:278.35Mardepodect
CAS:Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.Formula:C25H20N4OPurezza:99.81% - 99.94%Colore e forma:SolidPeso molecolare:392.45BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Formula:C13H12FN5Purezza:99.45%Colore e forma:SolidPeso molecolare:257.27MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Formula:C16H12ClN3O2Purezza:99.45%Colore e forma:SolidPeso molecolare:313.74HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Formula:C24H19BFNO5SPurezza:99.88%Colore e forma:SolidPeso molecolare:463.29Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Formula:C14H18N2OPurezza:99.83% - >99.99%Colore e forma:White SolidPeso molecolare:230.31ML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Formula:C20H20N4O4SPurezza:97.93%Colore e forma:SolidPeso molecolare:412.46SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Formula:C21H19N7Purezza:99.29%Colore e forma:SolidPeso molecolare:369.42YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Formula:C17H16ClN3OPurezza:99.84%Colore e forma:SolidPeso molecolare:313.78Cilostamide
CAS:<p>Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)</p>Formula:C20H26N2O3Purezza:98.87%Colore e forma:White To Off-White SolidPeso molecolare:342.43D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Formula:C21H19ClN2O2Purezza:97.57%Colore e forma:SolidPeso molecolare:366.84RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFormula:C19H14ClN5O4Purezza:99.25%Colore e forma:SolidPeso molecolare:411.8BRL-50481
CAS:<p>BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.</p>Formula:C9H12N2O4SPurezza:99.66%Colore e forma:SolidPeso molecolare:244.27Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Formula:C18H18Cl2N2O3Purezza:98.28% - 99.57%Colore e forma:SolidPeso molecolare:381.25Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFormula:C26H31N5O4Purezza:99.76% - 99.94%Colore e forma:SolidPeso molecolare:477.56Z-HA155
CAS:<p>Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.</p>Formula:C24H19BFNO5SPurezza:99.18%Colore e forma:SolidPeso molecolare:463.29Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Formula:C14H10BNO3Purezza:99.70%Colore e forma:SolidPeso molecolare:251.05Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Formula:C25H36N6O4SPurezza:99.90%Colore e forma:Off-White SolidPeso molecolare:516.66GSK256066
CAS:<p>GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold</p>Formula:C27H26N4O5SPurezza:99.60% - 99.66%Colore e forma:SolidPeso molecolare:518.58Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Formula:C21H17N3O4Purezza:99.42%Colore e forma:SolidPeso molecolare:375.38Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Formula:C23H32N6O4SPurezza:99.88%Colore e forma:White SolidPeso molecolare:488.6GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Formula:C13H16O3Purezza:99.533%Colore e forma:SolidPeso molecolare:220.26Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Formula:C12H12N2O2SPurezza:98.53%Colore e forma:SolidPeso molecolare:248.3MY-5445
CAS:<p>MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).</p>Formula:C20H14ClN3Purezza:99.77%Colore e forma:SolidPeso molecolare:331.8Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Formula:C21H18N4O4Purezza:99.85%Colore e forma:White PowderPeso molecolare:390.39Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Formula:C22H30N6O4S·xCH4O3SPurezza:99.84%Colore e forma:SolidPeso molecolare:570.68Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Formula:C23H32N6O5SPurezza:99.92%Colore e forma:SolidPeso molecolare:504.6[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Formula:C25H20N4OPurezza:99.5%Colore e forma:SolidPeso molecolare:391.45Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Formula:C16H17N5O2Purezza:99.93%Colore e forma:SolidPeso molecolare:311.34CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Formula:C23H19FN2O7Purezza:99.39%Colore e forma:SolidPeso molecolare:454.4Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Formula:C30H33FN8O2SPurezza:97% - 99.85%Colore e forma:SolidPeso molecolare:588.7PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Formula:C21H19N7Purezza:99.65%Colore e forma:SolidPeso molecolare:369.42RS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Formula:C19H13N5O4Purezza:98.98%Colore e forma:SolidPeso molecolare:375.34Lotamilast
CAS:<p>Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.</p>Formula:C26H24N4O5Purezza:97.03% - 99.29%Colore e forma:SolidPeso molecolare:472.49Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Formula:C17H17N3O3SPurezza:97.52%Colore e forma:SolidPeso molecolare:343.4GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Formula:C29H27F3N4O7SColore e forma:SolidPeso molecolare:632.61Crisaborole-d4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Formula:C14H6D4BNO3Colore e forma:SolidPeso molecolare:255.07
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