PDE
Le fosfodiesterasi (PDEs) sono enzimi che idrolizzano i nucleotidi ciclici, come cAMP e cGMP, nelle loro forme inattive, svolgendo un ruolo chiave nella regolazione delle vie di segnalazione intracellulare. Gli inibitori delle PDE sono utilizzati nel trattamento di varie condizioni, tra cui malattie cardiovascolari, disfunzione erettile e disturbi respiratori, grazie alla loro capacità di modulare i livelli di nucleotidi ciclici. Presso CymitQuimica, offriamo una gamma di inibitori delle PDE per supportare la tua ricerca nella segnalazione cellulare, farmacologia e sviluppo terapeutico.
Trovati 187 prodotti per "PDE".
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PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Formula:C21H19N7Purezza:99.65%Colore e forma:SolidPeso molecolare:369.42RS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Formula:C19H13N5O4Purezza:98.98%Colore e forma:White SolidPeso molecolare:375.34Ref: TM-T9239
1mg84,00€5mg168,00€1mL*10mM (DMSO)177,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Formula:C26H24N4O5Purezza:97.03% - 99.29%Colore e forma:SolidPeso molecolare:472.49Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Formula:C17H17N3O3SPurezza:97.52%Colore e forma:White SolidPeso molecolare:343.4Ref: TM-T7888
1mg126,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg394,00€25mg677,00€50mg954,00€100mg1.288,00€GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Formula:C29H27F3N4O7SColore e forma:SolidPeso molecolare:632.61Crisaborole-D4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Formula:C14H6D4BNO3Colore e forma:White SolidPeso molecolare:255.07ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Formula:C22H19N3O4Purezza:98%Colore e forma:SolidPeso molecolare:389.4Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Formula:C40H37N5OPurezza:99.4%Colore e forma:SolidPeso molecolare:603.75PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Formula:C19H17ClN2O2Purezza:99.55%Colore e forma:White SolidPeso molecolare:340.8K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Formula:C22H29N3O4Purezza:98%Colore e forma:SolidPeso molecolare:399.48Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C30H39ClN6O4S2Purezza:98%Colore e forma:SolidPeso molecolare:647.25Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Formula:C13H12N4OPurezza:97.04% - 98.31%Colore e forma:Yellow SolidPeso molecolare:240.26PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Formula:C22H18ClF2N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:461.91(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Formula:C15H20N4O3Colore e forma:SolidPeso molecolare:304.34KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Formula:C25H35N7O6SPurezza:99.55%Colore e forma:SolidPeso molecolare:561.65Lirimilast
CAS:Lirimilast is a PDE4 inhibitor for respiratory disease research.Formula:C17H12Cl2N2O6SPurezza:99.68%Colore e forma:SolidPeso molecolare:443.26Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Formula:C15H22N4O3Purezza:99.76% - 99.86%Colore e forma:SolidPeso molecolare:306.36Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Formula:C15H15ClN4OPurezza:99.93%Colore e forma:SolidPeso molecolare:302.76Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C32H40ClF3N6O6S2Purezza:98%Colore e forma:SolidPeso molecolare:761.28AN3199
CAS:AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.Formula:C17H18BNO5Purezza:99.45%Colore e forma:SolidPeso molecolare:327.14GRI918013
CAS:GRI918013 is a compound that competitively inhibits the autocrine motility factor (ATX/NPP2), thereby suppressing tumor cell invasion and metastasis.Formula:C17H15Cl2FN2O4SPurezza:99.80%Colore e forma:White SolidPeso molecolare:433.28PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Formula:C17H23FN6O2Purezza:99.86%Colore e forma:SolidPeso molecolare:362.4Ref: TM-T12395
1mg40,00€1mL*10mM (DMSO)88,00€5mg89,00€10mg130,00€25mg222,00€50mg324,00€100mg470,00€200mg665,00€BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Formula:C15H12ClF3N4OColore e forma:SolidPeso molecolare:356.73WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Formula:C23H28N4O4Purezza:99.67%Colore e forma:SolidPeso molecolare:424.49Ref: TM-T13331
1mg50,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg155,00€25mg224,00€50mg315,00€100mg424,00€200mg560,00€PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Formula:C14H11ClN2O3SPurezza:98%Colore e forma:Yellow SolidPeso molecolare:322.77Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Formula:C13H13ClN4OPurezza:98.97%Colore e forma:SolidPeso molecolare:276.72Prinoxodan
CAS:Prinoxodan is a PDE3 inhibitor; elevates cAMP; cardiotonic agent; vasodilatory activity; heart failure research.Formula:C13H14N4O2Purezza:98.99%Colore e forma:White SolidPeso molecolare:258.28Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Formula:C21H23N7O2Purezza:98%Colore e forma:SolidPeso molecolare:405.45ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Formula:C22H18ClF3N6OPurezza:99.73%Colore e forma:SolidPeso molecolare:474.87Ref: TM-T10409
1mg46,00€5mg94,00€1mL*10mM (DMSO)96,00€10mg149,00€25mg245,00€50mg338,00€100mg460,00€200mg622,00€Tilivapram
CAS:Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.Formula:C16H15Cl2N3O4Purezza:99.87%Colore e forma:White SolidPeso molecolare:384.21Trequinsin hydrochloride
CAS:Azetirelin (YM 14673) is a new thyrotropin-releasing hormone (TRH) analog.Formula:C24H28ClN3O3Purezza:99.91% - 99.95%Colore e forma:Yellow SolidPeso molecolare:441.95Ref: TM-T23476
2mg85,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg203,00€25mg442,00€50mg737,00€100mg1.071,00€Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFormula:C19H31N7O4Purezza:99.31% - 99.78%Colore e forma:SolidPeso molecolare:421.49Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.Formula:C14H13N3O2SPurezza:98.66%Colore e forma:Yellow SolidPeso molecolare:287.34Dasantafil
CAS:Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.Formula:C22H28BrN5O5Purezza:99.4% - 99.50%Colore e forma:SolidPeso molecolare:522.39Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Formula:C18H21N5SPurezza:99.55%Colore e forma:SolidPeso molecolare:339.46AWD 12-281
CAS:AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).Formula:C22H14Cl2FN3O3Purezza:99.25% - 99.85%Colore e forma:SolidPeso molecolare:458.27Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Formula:C24H28N2O6SPurezza:98.75% - 99.93%Colore e forma:SolidPeso molecolare:472.55PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFormula:C20H23ClN4O2Purezza:99.79%Colore e forma:SolidPeso molecolare:386.88Ref: TM-T10201
1mg225,00€5mg480,00€1mL*10mM (DMSO)540,00€10mg642,00€25mg964,00€50mg1.288,00€100mg1.738,00€200mg2.332,00€Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Formula:C15H15N3OPurezza:99.96%Colore e forma:SolidPeso molecolare:253.3PF-04447943
CAS:PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.Formula:C20H25N7O2Purezza:97.01% - 99.36%Colore e forma:SolidPeso molecolare:395.46MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Formula:C25H18N4O3Purezza:99.14%Colore e forma:Yellow SolidPeso molecolare:422.44Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Formula:C18H24N4O4Purezza:99.3%Colore e forma:SolidPeso molecolare:360.41Autotaxin-IN-3
CAS:Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.Formula:C22H21N9O2Purezza:99.54% - 99.79%Colore e forma:SolidPeso molecolare:443.46Ref: TM-T10415
2mg43,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg173,00€50mg269,00€100mg432,00€200mg592,00€Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Formula:C15H20N2O4Purezza:98.93% - 99.99%Colore e forma:SolidPeso molecolare:292.33Ref: TM-T31792
1mg156,00€1mL*10mM (DMSO)333,00€5mg366,00€10mg487,00€25mg737,00€50mg982,00€100mg1.324,00€200mg1.791,00€Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFormula:C12H18N4O2Purezza:98.4% - 99.8%Colore e forma:White SolidPeso molecolare:250.3PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Formula:C19H18ClN3O2SPurezza:99.32%Colore e forma:Yellow SolidPeso molecolare:387.88Ref: TM-T36832
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg205,00€50mg334,00€100mg537,00€500mg1.134,00€uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Formula:C26H24F3N3O4Purezza:99.90%Colore e forma:SolidPeso molecolare:499.48Ref: TM-T67815
1mg150,00€5mg360,00€1mL*10mM (DMSO)445,00€10mg540,00€25mg863,00€50mg1.153,00€100mg1.575,00€500mg3.142,00€PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Formula:C25H21N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:491.52Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Formula:C16H14N4OPurezza:99.52% - >99.99%Colore e forma:SolidPeso molecolare:278.31CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Formula:C23H19N5O2Colore e forma:SolidPeso molecolare:397.43
