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PDE

PDE

Le fosfodiesterasi (PDEs) sono enzimi che idrolizzano i nucleotidi ciclici, come cAMP e cGMP, nelle loro forme inattive, svolgendo un ruolo chiave nella regolazione delle vie di segnalazione intracellulare. Gli inibitori delle PDE sono utilizzati nel trattamento di varie condizioni, tra cui malattie cardiovascolari, disfunzione erettile e disturbi respiratori, grazie alla loro capacità di modulare i livelli di nucleotidi ciclici. Presso CymitQuimica, offriamo una gamma di inibitori delle PDE per supportare la tua ricerca nella segnalazione cellulare, farmacologia e sviluppo terapeutico.

Trovati 166 prodotti di "PDE"

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  • Gisadenafil
    Targetmol
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    Gisadenafil

    CAS:
    Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.
    Formula:C23H33N7O5S
    Purezza:98.82% - 99.50%
    Colore e forma:Solid
    Peso molecolare:519.62

    Ref: TM-T15381

  • PDE9-IN-(S)-C33
    Targetmol
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    PDE9-IN-(S)-C33

    CAS:
    <p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>
    Formula:C18H20ClN5O
    Purezza:98.75%
    Colore e forma:Solid
    Peso molecolare:357.84

    Ref: TM-T28352

  • TP-10
    Targetmol
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    TP-10

    CAS:
    TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
    Formula:C26H19F3N4O
    Purezza:99.21%
    Colore e forma:Solid
    Peso molecolare:460.45

    Ref: TM-T13189

  • AMG 579
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    AMG 579

    CAS:
    AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
    Formula:C25H23N5O3
    Purezza:99.87%
    Colore e forma:Solid
    Peso molecolare:441.48

    Ref: TM-T14217

  • Enpp-1-IN-16
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    Enpp-1-IN-16

    CAS:
    Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.
    Formula:C23H32N4O4
    Purezza:99.87%
    Colore e forma:Solid
    Peso molecolare:428.52

    Ref: TM-T78169

  • Cudetaxestat
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    Cudetaxestat

    CAS:
    Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.
    Formula:C21H15Cl2F2N3O2S
    Purezza:99.9%
    Colore e forma:Solid
    Peso molecolare:482.33

    Ref: TM-T63190

  • TPN171
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    TPN171

    CAS:
    <p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>
    Formula:C24H35N5O3
    Purezza:>99.99%
    Colore e forma:Solid
    Peso molecolare:441.57

    Ref: TM-T13193

  • NHTD
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    NHTD

    CAS:
    NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).
    Formula:C24H26N2O5
    Colore e forma:Solid
    Peso molecolare:422.47

    Ref: TM-T200095

  • PF-00489791
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    PF-00489791

    CAS:
    PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.
    Formula:C20H28N8O4S
    Purezza:99.97%
    Colore e forma:Solid
    Peso molecolare:476.55

    Ref: TM-T28360

  • Deltasonamide 2 hydrochloride
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    Deltasonamide 2 hydrochloride

    Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.
    Formula:C30H40Cl2N6O4S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:683.71

    Ref: TM-T10994L

  • TAK-915
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    TAK-915

    CAS:
    TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.
    Formula:C19H18F4N4O5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:458.36

    Ref: TM-T16976

  • BMS-341400 mesylate
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    BMS-341400 mesylate

    CAS:
    BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.
    Formula:C24H26ClN9O5S
    Colore e forma:Solid
    Peso molecolare:588.039

    Ref: TM-T204188

  • Thioquinapiperifil dihydrochloride
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    Thioquinapiperifil dihydrochloride

    CAS:
    Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.
    Formula:C24H29ClN6OS
    Purezza:99.81%
    Colore e forma:Solid
    Peso molecolare:485.05

    Ref: TM-T9773

  • Z21090
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    Z21090

    CAS:
    <p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>
    Formula:C12H14ClN3O3
    Colore e forma:Solid
    Peso molecolare:283.71

    Ref: TM-T87655

  • ASP9831
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    ASP9831

    CAS:
    <p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>
    Formula:C20H23N3O3
    Colore e forma:Solid
    Peso molecolare:353.42

    Ref: TM-T207494

  • Tovinontrine
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    Tovinontrine

    CAS:
    Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.
    Formula:C21H26N6O2
    Purezza:98.8%
    Colore e forma:Solid
    Peso molecolare:394.47

    Ref: TM-T61833