SGK
La chinasi regolata da siero e glucocorticoidi (SGK) è una proteina chinasi coinvolta nella regolazione di vari processi cellulari, tra cui il trasporto ionico, la sopravvivenza cellulare e il metabolismo del glucosio. Gli inibitori di SGK sono preziosi nello studio di condizioni come l'ipertensione, il diabete e il cancro, dove l'attività della SGK svolge un ruolo cruciale. Questi inibitori aiutano a comprendere le vie di segnalazione regolate da SGK e le loro implicazioni nelle malattie. Presso CymitQuimica, offriamo inibitori di SGK per supportare la tua ricerca in segnalazione cellulare, malattie metaboliche e terapia del cancro.
Trovati 10 prodotti di "SGK"
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SGK1-IN-3 hydrochloride
SGK1-IN-3 hydrochloride (compound 3a) is an efficacious, orally bioavailable SGK1 inhibitor. The serine/threonine kinase SGK1 acts as an activator of the β-catenin pathway and strongly stimulates cartilage degradation, being upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride holds potential for osteoarthritis research.Formula:C23H21Cl3N6O3SPeso molecolare:566.04614308-R-C4-PEG3-C1-Boc
CAS:308-R-C4-PEG3-C1-Boc is an SGK3 ligand-linker conjugate, utilized in the synthesis of PROTAC SGK3 degrader-2.Formula:C39H53FN6O9SColore e forma:SolidPeso molecolare:800.94SGK1-IN-4
CAS:SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.Formula:C23H21ClFN5O4SPurezza:97.03%Colore e forma:SolidPeso molecolare:517.96Ref: TM-T9977
1mg105,00€5mg250,00€10mg356,00€25mg580,00€50mg782,00€100mg1.044,00€200mg1.404,00€1mL*10mM (DMSO)301,00€SI-113
CAS:SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.Formula:C23H24N6OPurezza:98.93%Colore e forma:SolidPeso molecolare:400.48Ref: TM-T9589
1mg43,00€2mg56,00€5mg93,00€10mg133,00€25mg236,00€50mg354,00€100mg518,00€1mL*10mM (DMSO)101,00€CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formula:C11H14Cl3N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:358.67Ref: TM-T19913
1mg108,00€5mg207,00€10mg309,00€25mg497,00€50mg675,00€100mg909,00€200mg1.224,00€1mL*10mM (DMSO)225,00€GSK 650394
CAS:GSK 650394 is an inhibitor of serum- and glucocorticoid-regulated kinases (SGK). GSK 650394 has antitumor activity. Cost-effective and quality-assured.Formula:C25H22N2O2Purezza:97.46% - >99.99%Colore e forma:SolidPeso molecolare:382.45Ref: TM-T2622
1mg38,00€2mg50,00€5mg84,00€10mg105,00€25mg197,00€50mg313,00€100mg447,00€200mg623,00€1mL*10mM (DMSO)93,00€EMD638683
CAS:EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).Formula:C18H18F2N2O4Purezza:98%Colore e forma:SolidPeso molecolare:364.34Ref: TM-T6635
1mg74,00€2mg92,00€5mg150,00€10mg233,00€25mg358,00€50mg517,00€100mg737,00€200mg982,00€1mL*10mM (DMSO)120,00€SGK1-IN-1
CAS:SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitorFormula:C17H12ClFN6O2SPurezza:98%Colore e forma:SolidPeso molecolare:418.83EMD638683 R-Form
CAS:EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.Formula:C18H18F2N2O4Colore e forma:SolidPeso molecolare:364.34SGK1-IN-6
CAS:SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.Formula:C30H30F3N5O4Colore e forma:SolidPeso molecolare:581.586
