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SGK

SGK

La chinasi regolata da siero e glucocorticoidi (SGK) è una proteina chinasi coinvolta nella regolazione di vari processi cellulari, tra cui il trasporto ionico, la sopravvivenza cellulare e il metabolismo del glucosio. Gli inibitori di SGK sono preziosi nello studio di condizioni come l'ipertensione, il diabete e il cancro, dove l'attività della SGK svolge un ruolo cruciale. Questi inibitori aiutano a comprendere le vie di segnalazione regolate da SGK e le loro implicazioni nelle malattie. Presso CymitQuimica, offriamo inibitori di SGK per supportare la tua ricerca in segnalazione cellulare, malattie metaboliche e terapia del cancro.

Trovati 11 prodotti di "SGK"

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  • PROTAC SGK3 degrader-1
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    PROTAC SGK3 degrader-1

    CAS:
    PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligands to VH032 VHL to induce endogenous SGK3 degradation.
    Formula:C57H73FN10O11S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:1157.38

    Ref: TM-T13847

  • SGK1-IN-4
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    SGK1-IN-4

    CAS:
    <p>SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.</p>
    Formula:C23H21ClFN5O4S
    Purezza:97.03%
    Colore e forma:Solid
    Peso molecolare:517.96

    Ref: TM-T9977

  • Logo CymitQuimica
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    SGK1-IN-3 hydrochloride

    SGK1-IN-3 hydrochloride (compound 3a) is an efficacious, orally bioavailable SGK1 inhibitor. The serine/threonine kinase SGK1 acts as an activator of the β-catenin pathway and strongly stimulates cartilage degradation, being upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride holds potential for osteoarthritis research.
    Formula:C23H21Cl3N6O3S
    Peso molecolare:566.04614

    Ref: TM-T210357

  • 308-R-C4-PEG3-C1-Boc
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    308-R-C4-PEG3-C1-Boc

    CAS:
    308-R-C4-PEG3-C1-Boc is an SGK3 ligand-linker conjugate, utilized in the synthesis of PROTAC SGK3 degrader-2.
    Formula:C39H53FN6O9S
    Colore e forma:Solid
    Peso molecolare:800.94

    Ref: TM-T212100

  • EMD638683
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    EMD638683

    CAS:
    EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).
    Formula:C18H18F2N2O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:364.34

    Ref: TM-T6635

  • SI-113
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    SI-113

    CAS:
    SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
    Formula:C23H24N6O
    Purezza:98.93%
    Colore e forma:Solid
    Peso molecolare:400.48

    Ref: TM-T9589

  • GSK 650394
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    GSK 650394

    CAS:
    GSK 650394 is an inhibitor of serum- and glucocorticoid-regulated kinases (SGK). GSK 650394 has antitumor activity. Cost-effective and quality-assured.
    Formula:C25H22N2O2
    Purezza:97.46% - >99.99%
    Colore e forma:Solid
    Peso molecolare:382.45

    Ref: TM-T2622

  • CKI-7
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    CKI-7

    CAS:
    CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.
    Formula:C11H14Cl3N3O2S
    Purezza:>99.99%
    Colore e forma:Solid
    Peso molecolare:358.67

    Ref: TM-T19913

  • SGK1-IN-1
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    SGK1-IN-1

    CAS:
    SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitor
    Formula:C17H12ClFN6O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:418.83

    Ref: TM-T12890

  • EMD638683 R-Form
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    EMD638683 R-Form

    CAS:
    EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
    Formula:C18H18F2N2O4
    Colore e forma:Solid
    Peso molecolare:364.34

    Ref: TM-T11181

  • SGK1-IN-6
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    SGK1-IN-6

    CAS:
    <p>SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.</p>
    Formula:C30H30F3N5O4
    Colore e forma:Solid
    Peso molecolare:581.586

    Ref: TM-T205289