Caseina chinasi
Le caseina chinasi sono una famiglia di proteine chinasi serina/treonina che regolano vari processi cellulari, tra cui la riparazione del DNA, i ritmi circadiani e la trasduzione del segnale. Queste chinasi sono coinvolte nella fosforilazione di numerose proteine e sono implicate in malattie come il cancro, i disturbi neurodegenerativi e le sindromi metaboliche. Presso CymitQuimica, offriamo una selezione di inibitori della caseina chinasi per supportare la tua ricerca nella trasduzione del segnale, nella regolazione del ciclo cellulare e nello sviluppo terapeutico.
Trovati 137 prodotti di "Caseina chinasi"
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Casein kinase 1δ-IN-8
CAS:Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.Formula:C19H14FN5OSPurezza:99.56%Colore e forma:SolidPeso molecolare:379.41Casein kinase 1δ-IN-9
CAS:<p>Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.</p>Formula:C15H12ClN3Purezza:99.93%Colore e forma:SolidPeso molecolare:269.73GSK-3β/CK-1δ-IN-1
GSK-3β/CK-1δ-IN-1 (8d) is a dual inhibitor of GSK-3β and CK-1δ that can cross the blood-brain barrier, with IC50 values of 0.77 μM and 0.57 μM, respectively. GSK-3β/CK-1δ-IN-1 (8d) is applicable in neuroblastoma research.Formula:C22H17F3N4OColore e forma:SolidPeso molecolare:410.39Casein kinase 1δ-IN-7
CAS:Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.Formula:C17H14N4O2SPurezza:98.02%Colore e forma:SolidPeso molecolare:338.38QXG-6442
QXG-6442 is a molecular glue degrader targeting CK1α, demonstrating a degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. In the MOLM-14 cell line, QXG-6442 induces antiproliferative effects.Formula:C21H17N5O4Colore e forma:SolidPeso molecolare:403.39CK1δ/CK1ε liagnd-1
CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.Formula:C21H20F2N6Colore e forma:SolidPeso molecolare:394.42Ellagic acid (hydrate)
CAS:Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).Formula:C14H8O9Purezza:98%Colore e forma:Green To Beige PowderPeso molecolare:320.21CZP-IN-1
CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi protease (CZP) without affecting cathepsin L (IC50=28 nM). This compound is applicable in Chagas disease research.Formula:C20H26N4O4SColore e forma:SolidPeso molecolare:418.51MU1742
MU1742 is a probe for CK1δ and CK1ε protein kinases [1] .Formula:C22H22F2N6Colore e forma:SolidPeso molecolare:408.45AH078
AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.Formula:C51H60F2N10O5SColore e forma:SolidPeso molecolare:963.15WAY-297174
CAS:<p>WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.</p>Formula:C11H12N2O2S2Purezza:99.53%Colore e forma:SoildPeso molecolare:268.36FPFT-2216
CAS:FPFT-2216 is a "molecular glue" compound with potential anti-tumor activity that degrades IKZF6, IKZF1, DE1D and can be used to study immune system diseases.Formula:C12H12N4O3SPurezza:99.35% - 99.62%Colore e forma:SolidPeso molecolare:292.31Ref: TM-T60608
1mg97,00€5mg235,00€10mg354,00€25mg747,00€50mg1.169,00€100mg1.882,00€200mg2.547,00€1mL*10mM (DMSO)250,00€MRT00033659
CAS:MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.Formula:C15H14N4OColore e forma:SolidPeso molecolare:266.3SGC-CK2-1
CAS:SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.Formula:C20H21N7OPurezza:99.41%Colore e forma:SolidPeso molecolare:375.43PF-5006739
CAS:PF-5006739: potent, selective CK1δ/ε inhibitor (IC50: 3.9/17.0 nM); may treat psychiatric disorders, improves glucose tolerance, reduces opioid seeking.Formula:C22H22FN7OPurezza:98%Colore e forma:SolidPeso molecolare:419.45TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Formula:C20H12F3N3Purezza:99.55% - 99.94%Colore e forma:SolidPeso molecolare:351.32Ref: TM-T4645
2mg35,00€5mg52,00€10mg85,00€25mg156,00€50mg235,00€100mg329,00€200mg464,00€1mL*10mM (DMSO)71,00€PF-670462
CAS:PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.Formula:C19H22Cl2FN5Purezza:99.42% - 99.72%Colore e forma:SolidPeso molecolare:410.32CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Formula:C24H15F2N3Purezza:98.79%Colore e forma:SolidPeso molecolare:383.39Ref: TM-T5393
1mg49,00€2mg65,00€5mg97,00€10mg160,00€25mg305,00€50mg472,00€100mg707,00€1mL*10mM (DMSO)106,00€Silmitasertib
CAS:Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).Formula:C19H12ClN3O2Purezza:98% - 99.90%Colore e forma:SolidPeso molecolare:349.77Ref: TM-T2259
1mg40,00€2mg51,00€5mg85,00€10mg125,00€25mg207,00€50mg329,00€100mg520,00€500mg1.111,00€1mL*10mM (DMSO)93,00€Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formula:C16H16F3N5Purezza:99.97%Colore e forma:SolidPeso molecolare:335.33
