Caseina chinasi
Le caseina chinasi sono una famiglia di proteine chinasi serina/treonina che regolano vari processi cellulari, tra cui la riparazione del DNA, i ritmi circadiani e la trasduzione del segnale. Queste chinasi sono coinvolte nella fosforilazione di numerose proteine e sono implicate in malattie come il cancro, i disturbi neurodegenerativi e le sindromi metaboliche. Presso CymitQuimica, offriamo una selezione di inibitori della caseina chinasi per supportare la tua ricerca nella trasduzione del segnale, nella regolazione del ciclo cellulare e nello sviluppo terapeutico.
Trovati 137 prodotti di "Caseina chinasi"
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Ellagic acid
CAS:Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid is an antioxidant. Cost-effective and quality-assured.Formula:C14H6O8Purezza:97.11% - 99.75%Colore e forma:Cream Colored Needles From Pyridine 1992)Peso molecolare:302.19NMS-P715
CAS:NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).Formula:C35H39F3N8O3Purezza:99.84%Colore e forma:SolidPeso molecolare:676.73Emodin
CAS:Emodin (Frangula emodin) is a selective 11β-HSD1 inhibitor,IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice. High-Quality, Low-Cost!Formula:C15H10O5Purezza:98.37% - 99.53%Colore e forma:Physical Description Orange Needles Or Powder (Ntp 1992)Peso molecolare:270.24A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formula:C12H14Cl2N2O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:321.22Silmitasertib sodium salt
CAS:Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).Formula:C19H11ClN3NaO2Purezza:99.49% - 99.62%Colore e forma:SolidPeso molecolare:371.75CK2-IN-15
CK2-IN-15 (Compound Biv5) is a selective and potent inhibitor of the enzyme protein kinase CK2, with an IC50 value of 51 pM. It significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also decreases viral replication in an in vitro model of human nasal epithelial cells. CK2-IN-15 holds potential for research into diseases related to β-coronavirus infections.Colore e forma:Odour SolidWAY-297174
CAS:<p>WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.</p>Formula:C11H12N2O2S2Purezza:99.53%Colore e forma:SoildPeso molecolare:268.36MU1742
MU1742 is a probe for CK1δ and CK1ε protein kinases [1] .Formula:C22H22F2N6Colore e forma:SolidPeso molecolare:408.45Casein Kinase Substrates 3
CAS:Casein Kinase Substrates 3 is a substrate of casein kinase.Formula:C85H139N27O35SPurezza:98%Colore e forma:SolidPeso molecolare:2131.24GSK-3β/CK-1δ-IN-1
GSK-3β/CK-1δ-IN-1 (8d) is a dual inhibitor of GSK-3β and CK-1δ that can cross the blood-brain barrier, with IC50 values of 0.77 μM and 0.57 μM, respectively. GSK-3β/CK-1δ-IN-1 (8d) is applicable in neuroblastoma research.Formula:C22H17F3N4OColore e forma:SolidPeso molecolare:410.39CK2-IN-13
CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with an IC50 value of 5.8 nM, playing a significant role in cancer research.Formula:C19H13Br2NO3Colore e forma:SolidPeso molecolare:463.119Ellagic acid (hydrate)
CAS:Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).Formula:C14H8O9Purezza:98%Colore e forma:Green To Beige PowderPeso molecolare:320.21AH081
AH081 (Compound 38) is a CK1δ/ε PROTAC degrader and serves as the negative control for AH078. It maintains inhibitory activity against CK1δ/ε but lacks degradation activity due to the use of an inactive stereoisomer of the VHL ligand.Colore e forma:Odour SolidQXG-6442
QXG-6442 is a molecular glue degrader targeting CK1α, demonstrating a degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. In the MOLM-14 cell line, QXG-6442 induces antiproliferative effects.Formula:C21H17N5O4Colore e forma:SolidPeso molecolare:403.39Casein kinase 1δ-IN-6
CAS:CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.Formula:C16H10ClF3N2OSPurezza:99.87%Colore e forma:SoildPeso molecolare:370.78Casein Kinase 2 Substrate Peptide
CAS:CK2 Substrate Peptide, C-terminus linked to EDANS, used for CK2 activity assays.Formula:C45H73N19O24Colore e forma:SolidPeso molecolare:1264.17Casein kinase 1δ-IN-3
CAS:<p>Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.</p>Formula:C17H16N2O2SPurezza:98.94%Colore e forma:SoildPeso molecolare:312.39TBCA
CAS:TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.Formula:C9H4Br4O2Purezza:99.3%Colore e forma:SolidPeso molecolare:463.74Casein kinase 1δ-IN-7
CAS:Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.Formula:C17H14N4O2SPurezza:98.02%Colore e forma:SolidPeso molecolare:338.38Casein kinase 1δ-IN-8
CAS:Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.Formula:C19H14FN5OSPurezza:99.56%Colore e forma:SolidPeso molecolare:379.41CSNK2-IN-2
CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.Formula:C25H30FN9OColore e forma:SolidPeso molecolare:491.56CK2-IN-14
CK2-IN-14 (Compound 10b) is an inhibitor of cyclin-dependent kinase 2α with an IC50 of 36.7 nM. It effectively hinders the growth of cancer cell lines 786-O and U937, with GI50 values of 7.3 μM and 7.5 μM, respectively.Formula:C19H20ClN5SColore e forma:SolidPeso molecolare:385.91Casein kinase 1δ-IN-9
CAS:<p>Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.</p>Formula:C15H12ClN3Purezza:99.93%Colore e forma:SolidPeso molecolare:269.73Casein
CAS:Casein is a milk protein with multiple roles involved in novel drug delivery systems.Purezza:95%Colore e forma:SoildCK1-IN-4
CK1-IN-4 (Compound 59) is an inhibitor of casein kinase CK1δ with an IC50 of 2.74 μM. It exhibits neuroprotective activity in SH-SY5Y cells treated with Ethacrynic acid.Colore e forma:Odour SolidCK1δ/CK1ε liagnd-1
CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.Formula:C21H20F2N6Colore e forma:SolidPeso molecolare:394.42CK1-IN-3
CAS:WAY-296817 inhibits CK1, potential for circadian rhythm and inflammation research.Formula:C17H16N2O3SPurezza:99.18%Colore e forma:SolidPeso molecolare:328.39Ref: TM-T60005
1mg35,00€5mg74,00€10mg101,00€25mg178,00€50mg258,00€100mg354,00€200mg485,00€1mL*10mM (DMSO)82,00€CZP-IN-1
CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi protease (CZP) without affecting cathepsin L (IC50=28 nM). This compound is applicable in Chagas disease research.Formula:C20H26N4O4SColore e forma:SolidPeso molecolare:418.51Casein kinase 1δ-IN-15
CAS:Casein kinase 1δ-IN-15, an inhibitor for casein kinase 1 (CK1δ), exhibits an IC50 of 0.045 μM [1].Formula:C19H17FN6OColore e forma:SolidPeso molecolare:364.38AH078
AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.Formula:C51H60F2N10O5SColore e forma:SolidPeso molecolare:963.15Casein kinase 1δ-IN-14
CAS:Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.Formula:C17H11ClN4O2Purezza:99.66%Colore e forma:SolidPeso molecolare:338.75FPFT-2216
CAS:FPFT-2216 is a "molecular glue" compound with potential anti-tumor activity that degrades IKZF6, IKZF1, DE1D and can be used to study immune system diseases.Formula:C12H12N4O3SPurezza:99.35% - 99.62%Colore e forma:SolidPeso molecolare:292.31Ref: TM-T60608
1mg97,00€5mg235,00€10mg354,00€25mg747,00€50mg1.169,00€100mg1.882,00€200mg2.547,00€1mL*10mM (DMSO)250,00€PF-5006739
CAS:PF-5006739: potent, selective CK1δ/ε inhibitor (IC50: 3.9/17.0 nM); may treat psychiatric disorders, improves glucose tolerance, reduces opioid seeking.Formula:C22H22FN7OPurezza:98%Colore e forma:SolidPeso molecolare:419.45MRT00033659
CAS:MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.Formula:C15H14N4OColore e forma:SolidPeso molecolare:266.3SGC-CK2-1
CAS:SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.Formula:C20H21N7OPurezza:99.41%Colore e forma:SolidPeso molecolare:375.43TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Formula:C20H12F3N3Purezza:99.55% - 99.94%Colore e forma:SolidPeso molecolare:351.32Ref: TM-T4645
2mg35,00€5mg52,00€10mg85,00€25mg156,00€50mg235,00€100mg329,00€200mg464,00€1mL*10mM (DMSO)71,00€PF-670462
CAS:PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.Formula:C19H22Cl2FN5Purezza:99.42% - 99.72%Colore e forma:SolidPeso molecolare:410.32CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Formula:C24H15F2N3Purezza:98.79%Colore e forma:SolidPeso molecolare:383.39Ref: TM-T5393
1mg49,00€2mg65,00€5mg97,00€10mg160,00€25mg305,00€50mg472,00€100mg707,00€1mL*10mM (DMSO)106,00€TTP 22
CAS:TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.Formula:C16H14N2O2S2Purezza:97.08% - 97.78%Colore e forma:SolidPeso molecolare:330.42Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formula:C16H16F3N5Purezza:99.97%Colore e forma:SolidPeso molecolare:335.33LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Formula:C19H17NO3Purezza:98% - 99.96%Colore e forma:Pale Yellow SolidPeso molecolare:307.34SR-3029
CAS:SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.Formula:C23H19F3N8OPurezza:99.64%Colore e forma:SolidPeso molecolare:480.45NCC007
CAS:NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.Formula:C22H28F3N7Purezza:98.88%Colore e forma:SolidPeso molecolare:447.5(E/Z)-GO289
CAS:<p>(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.</p>Formula:C17H15BrN4O2SPurezza:98.1%Colore e forma:SolidPeso molecolare:419.3AS-252424
CAS:AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Formula:C14H8FNO4SPurezza:99.06% - 99.09%Colore e forma:SolidPeso molecolare:305.28Ref: TM-T6208
1mg39,00€2mg50,00€5mg81,00€10mg135,00€25mg216,00€50mg325,00€100mg472,00€500mg1.026,00€1mL*10mM (DMSO)88,00€Umbralisib hydrochloride
CAS:Umbralisib hydrochloride: PI3Kδ inhibitor; IC50=22.2 nM, EC50=24.3 nM; active vs CK1ε, EC50=6.0 μM.Formula:C31H25ClF3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:608.01CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formula:C11H14Cl3N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:358.67Ref: TM-T19913
1mg114,00€5mg217,00€10mg325,00€25mg525,00€50mg712,00€100mg959,00€200mg1.293,00€1mL*10mM (DMSO)239,00€TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Formula:C6HBr4N3Purezza:98.51% - 99.45%Colore e forma:Off-White SolidPeso molecolare:434.71DMAT
CAS:DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).Formula:C9H7Br4N3Purezza:99.48%Colore e forma:SolidPeso molecolare:476.79
