P450

CDD3505 increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.

DMU2105 is a specific CYP1B1 inhibitor(CYP1B1 and CYP1A1 with IC50 of 10 nM and 742 …

Chamomile is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. …

Dihydromethysticin is a kavalactone found in Piper methysticum. It has marked activity on the induction …

Curdione inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 …

Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 µM),

BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a …

CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an …

MCH-1 antagonist 1 also inhibits CYP3A4 (IC50: 10μM).MCH-1 antagonist 1 is a potent melanin concentrating …

Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant …

Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but …

BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). …

Abiraterone (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).

1. Bergaptol shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of …

Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of …

1-Aminobenzotriazole (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.

Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated …

Naloxegol oxalate is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.

DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 …

Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer …

Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.

DMU2139 is a potent and specific CYP1B1 inhibitor with IC50s of 9 nM and 795 …

Rhapontigenin is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl …

Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 …

Bergapten, a psoralen, inhibits cell replication.

Itraconazole is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.

Benzbromarone is a CYP2C9 inhibitor with Ki value of 19.3 nM.

Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an …

Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central …

BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : …

1. Corydaline, an isoquinoline alkaloid, is one of the major active constituents in a new …

CYP17-IN-1 is an effective oral CYP17 inhibitor that can inhibit CYP17 in rats and humans …

DMU2139 is a specific CYP1B1 inhibitor (CYP1B1 and CYP1A1 with IC50 of 9 nM and …

Epifriedelanol suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts (HDFs) and HUVECs. Because of …

1. Linderane was characterized as a mechanism-based inactivator of CYP2C9.

Sulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity …

Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human …

Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms …

TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, …

7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and …

Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.

Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA extracted from Savia …

Ginsenoside F1 is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the …

Soticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the …

Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is …

Proadifen hydrochloride is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.

Isosilybin and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug …

Pyributicarb is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Naringin Dihydrochalcone(Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.

1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and …

2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.

Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid …

Rosavin has antidepressant and anxiolytic actions, helps balance all the neurotransmitters.

AS1810722 is an orally active and potent STAT6 inhibitor(IC50 :1.9 nM). AS1810722 shows a good …

Diosmetin has been found to act as a weak TrkB receptor agonist.

Abiraterone acetate is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an …

Naringenin is a flavanone that is considered to have a bioactive effect on human health …

TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).

N-Nornuciferine is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: …