Prolil-idrossilasi HIF/HIF
Il fattore inducibile dall'ipossia (HIF) è un fattore di trascrizione che svolge un ruolo cruciale nelle risposte cellulari ai bassi livelli di ossigeno (ipossia). L'attività di HIF è strettamente regolata dalle prolyl-idrossilasi HIF, che bersagliano HIF per la degradazione in condizioni normossiche. Gli inibitori della prolyl-idrossilasi HIF possono stabilizzare HIF, promuovendo l'espressione di geni coinvolti nell'angiogenesi, eritropoiesi e metabolismo. Questi inibitori sono di grande interesse per il trattamento di condizioni come anemia, malattie ischemiche e cancro. Presso CymitQuimica, offriamo inibitori di HIF/prolyl-idrossilasi HIF per supportare la tua ricerca in biologia dell'ipossia, terapia anticancro e regolazione metabolica.
Trovati 142 prodotti di "Prolil-idrossilasi HIF/HIF"
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ZG-2033
CAS:<p>ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.</p>Formula:C15H14N2O2SColore e forma:SolidPeso molecolare:286.35TAT-cyclo-CLLFVY
CAS:Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formula:C111H188N42O24S2Purezza:98%Colore e forma:SolidPeso molecolare:2559.1HIF1-IN-3
CAS:<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Formula:C26H24N2O3Purezza:99.59%Colore e forma:SolidPeso molecolare:412.48Izilendustat
CAS:<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Formula:C22H28ClN3O4Purezza:99.95%Colore e forma:SolidPeso molecolare:433.93IOX2-NH2-Methyl
<p>IOX2-NH2-Methyl is a modified form of IOX2. IOX2 is a specific inhibitor of PHD2 (prolyl-hydroxylase-2), capable of upregulating HIF-1α expression and suppressing ROS production. IOX2-NH2-Methyl is employed in investigations of platelet and thrombus formation.</p>Formula:C20H19N3O5Purezza:97.64% - 99.31%Colore e forma:SolidPeso molecolare:381.39Mersalyl
CAS:Mersalyl is an organic mercurial diuretic.Formula:C13H16HgNNaO6Colore e forma:SolidPeso molecolare:505.854HSP90-IN-30
<p>HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.</p>Formula:C20H39B12N4O2Peso molecolare:499.41897Fibrostatin C
CAS:<p>Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.</p>Formula:C18H19NO8SColore e forma:SolidPeso molecolare:409.41VHL-IN-1
<p>VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and</p>Formula:C28H37FN4O4SPurezza:98%Colore e forma:SolidPeso molecolare:544.68HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Formula:C21H19N3OSPurezza:99.90% - >99.99%Colore e forma:SolidPeso molecolare:361.461,4-DPCA ethyl ester
CAS:<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>Formula:C15H12N2O3Purezza:99.54%Colore e forma:SolidPeso molecolare:268.27KG-548
CAS:<p>KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.</p>Formula:C9H4F6N4Purezza:99.62%Colore e forma:SolidPeso molecolare:282.15HIF-IN-1
CAS:<p>HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.</p>Formula:C17H12N2OPurezza:99.48%Colore e forma:SolidPeso molecolare:260.29dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Formula:C5H8N2O5Purezza:99.93% - ≥95%Colore e forma:SolidPeso molecolare:176.13N-Oxalylglycine
CAS:<p>N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.</p>Formula:C4H5NO5Purezza:99.23%Colore e forma:Colourless SolidPeso molecolare:147.09Dapagliflozin
CAS:<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Formula:C21H25ClO6Purezza:99.5% - 99.93%Colore e forma:SolidPeso molecolare:408.87FG-2216
CAS:<p>FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.</p>Formula:C12H9ClN2O4Purezza:97.1% - >99.99%Colore e forma:SolidPeso molecolare:280.66Glucosamine sulfate
CAS:<p>Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.</p>Formula:C6H13NO5·H2SO4Purezza:99.64%Colore e forma:White CrystalPeso molecolare:277.25ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Formula:C20H21N5O2Purezza:99.8%Colore e forma:SolidPeso molecolare:363.41DMOG
CAS:<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>Formula:C6H9NO5Purezza:80.23% - 99.98%Colore e forma:SolidPeso molecolare:175.14
