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Prolil-idrossilasi HIF/HIF

Prolil-idrossilasi HIF/HIF

Il fattore inducibile dall'ipossia (HIF) è un fattore di trascrizione che svolge un ruolo cruciale nelle risposte cellulari ai bassi livelli di ossigeno (ipossia). L'attività di HIF è strettamente regolata dalle prolyl-idrossilasi HIF, che bersagliano HIF per la degradazione in condizioni normossiche. Gli inibitori della prolyl-idrossilasi HIF possono stabilizzare HIF, promuovendo l'espressione di geni coinvolti nell'angiogenesi, eritropoiesi e metabolismo. Questi inibitori sono di grande interesse per il trattamento di condizioni come anemia, malattie ischemiche e cancro. Presso CymitQuimica, offriamo inibitori di HIF/prolyl-idrossilasi HIF per supportare la tua ricerca in biologia dell'ipossia, terapia anticancro e regolazione metabolica.

Trovati 142 prodotti di "Prolil-idrossilasi HIF/HIF"

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  • HIF-2α-IN-9
    Targetmol
    + Info

    HIF-2α-IN-9

    CAS:
    <p>HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within</p>
    Formula:C12H13F5O4S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:380.35

    Ref: TM-T78937

  • PHD-IN-1
    Targetmol
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    PHD-IN-1

    CAS:
    <p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>
    Formula:C24H23N7O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:441.49

    Ref: TM-T79797

  • AKB-6899
    Targetmol
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    AKB-6899

    CAS:
    <p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>
    Formula:C14H11FN2O4
    Purezza:97.87%
    Colore e forma:Solid
    Peso molecolare:290.25

    Ref: TM-T29797

  • HIF-2α-IN-1
    Targetmol
    + Info

    HIF-2α-IN-1

    CAS:
    <p>HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.</p>
    Formula:C16H8F5NO4S
    Purezza:97.99%
    Colore e forma:Solid
    Peso molecolare:405.3

    Ref: TM-T15482

  • CLB-016
    Targetmol
    + Info

    CLB-016

    CAS:
    <p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>
    Formula:C17H20N6O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:356.38

    Ref: TM-T23894

  • HIF-2α-IN-6
    Targetmol
    + Info

    HIF-2α-IN-6

    CAS:
    <p>HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].</p>
    Formula:C15H13F4NO3S
    Colore e forma:Solid
    Peso molecolare:363.33

    Ref: TM-T61367

  • NPAS3-IN-1
    Targetmol
    + Info

    NPAS3-IN-1

    CAS:
    <p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>
    Formula:C10H5N3O2S3
    Purezza:99.56%
    Colore e forma:Solid
    Peso molecolare:295.36

    Ref: TM-T81646

  • HIF-2α agonist 2
    Targetmol
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    HIF-2α agonist 2

    CAS:
    HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.
    Formula:C13H8Br2N2O2S
    Purezza:98.87%
    Colore e forma:Soild
    Peso molecolare:416.09

    Ref: TM-T67831

  • HIF-2α-IN-7
    Targetmol
    + Info

    HIF-2α-IN-7

    CAS:
    <p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>
    Formula:C18H9F6NO2
    Colore e forma:Solid
    Peso molecolare:385.26

    Ref: TM-T72997

  • HIF-2α-IN-5
    Targetmol
    + Info

    HIF-2α-IN-5

    CAS:
    <p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of &lt; 50 nM [1].</p>
    Formula:C15H12F4O3S2
    Colore e forma:Solid
    Peso molecolare:380.38

    Ref: TM-T61614

  • (Rac)-PT2399
    Targetmol
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    (Rac)-PT2399

    CAS:
    <p>(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).</p>
    Formula:C17H10F5NO4S
    Colore e forma:Solid
    Peso molecolare:419.32

    Ref: TM-T12675

  • JTZ-951 HCl
    Targetmol
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    JTZ-951 HCl

    CAS:
    <p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>
    Formula:C17H17ClN4O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:376.79

    Ref: TM-T27699

  • AFP464 free base
    Targetmol
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    AFP464 free base

    CAS:
    <p>AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.</p>
    Formula:C22H23F3N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:448.44

    Ref: TM-T10258

  • Logo CymitQuimica
    Targetmol
    + Info

    HIF-1α-IN-5

    <p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>
    Formula:C16H15N3O2
    Colore e forma:Solid
    Peso molecolare:281.31

    Ref: TM-T60532

  • DDO-3055
    Targetmol
    + Info

    DDO-3055

    CAS:
    <p>DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.</p>
    Formula:C17H13ClN2O5
    Colore e forma:Solid
    Peso molecolare:360.749

    Ref: TM-T205089

  • JPHM-2-167
    Targetmol
    + Info

    JPHM-2-167

    CAS:
    <p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>
    Formula:C30H28N6O2
    Colore e forma:Solid
    Peso molecolare:504.582

    Ref: TM-T205273

  • Logo CymitQuimica
    Targetmol
    + Info

    HIF-1α-IN-4

    <p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>
    Formula:C16H12N2O3
    Colore e forma:Solid
    Peso molecolare:280.28

    Ref: TM-T60524

  • DS44470011
    Targetmol
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    DS44470011

    CAS:
    <p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>
    Formula:C21H19N3O4
    Colore e forma:Solid
    Peso molecolare:377.39

    Ref: TM-T88182

  • PHD2-IN-4
    Targetmol
    + Info

    PHD2-IN-4

    CAS:
    <p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>
    Formula:C21H19N5O3
    Colore e forma:Solid
    Peso molecolare:389.407

    Ref: TM-T205562

  • Logo CymitQuimica
    Targetmol
    + Info

    HIF-1/2α-IN-1

    <p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>
    Formula:C17H16N6O4
    Colore e forma:Solid
    Peso molecolare:368.35

    Ref: TM-T61442