CymitQuimica logo
Prolil-idrossilasi HIF/HIF

Prolil-idrossilasi HIF/HIF

Il fattore inducibile dall'ipossia (HIF) è un fattore di trascrizione che svolge un ruolo cruciale nelle risposte cellulari ai bassi livelli di ossigeno (ipossia). L'attività di HIF è strettamente regolata dalle prolyl-idrossilasi HIF, che bersagliano HIF per la degradazione in condizioni normossiche. Gli inibitori della prolyl-idrossilasi HIF possono stabilizzare HIF, promuovendo l'espressione di geni coinvolti nell'angiogenesi, eritropoiesi e metabolismo. Questi inibitori sono di grande interesse per il trattamento di condizioni come anemia, malattie ischemiche e cancro. Presso CymitQuimica, offriamo inibitori di HIF/prolyl-idrossilasi HIF per supportare la tua ricerca in biologia dell'ipossia, terapia anticancro e regolazione metabolica.

Trovati 142 prodotti di "Prolil-idrossilasi HIF/HIF"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • HIF-PHD-IN-2
    Targetmol
    + Info

    HIF-PHD-IN-2

    CAS:
    <p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>
    Formula:C17H15N5O3S
    Colore e forma:Solid
    Peso molecolare:369.4

    Ref: TM-T61458

  • Logo CymitQuimica
    Targetmol
    + Info

    Angiogenesis agent 1

    CAS:
    <p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>
    Formula:C20H24O7
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:376.4

    Ref: TM-T74217

  • BNS
    Targetmol
    + Info

    BNS

    CAS:
    <p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>
    Formula:C18H16N2O6S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:420.46

    Ref: TM-T26880

  • M1002
    Targetmol
    + Info

    M1002

    CAS:
    <p>M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.</p>
    Formula:C15H8F6N2O2S
    Purezza:99.95%
    Colore e forma:Solid
    Peso molecolare:394.29

    Ref: TM-T61822

  • 103D5R
    Targetmol
    + Info

    103D5R

    CAS:
    <p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>
    Formula:C20H21N3O2
    Colore e forma:Solid
    Peso molecolare:335.4

    Ref: TM-T68718

  • HIF-IN-33
    Targetmol
    + Info

    HIF-IN-33

    CAS:
    <p>HIF-IN-33 is an inhibitor of HIF pathway.</p>
    Formula:C21H17F3N4O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:414.38

    Ref: TM-T25502

  • Langkamide
    Targetmol
    + Info

    Langkamide

    CAS:
    <p>Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.</p>
    Formula:C16H17NO5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:303.31

    Ref: TM-T27796

  • ENMD-1198
    Targetmol
    + Info

    ENMD-1198

    CAS:
    <p>ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.</p>
    Formula:C20H25NO2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:311.42

    Ref: TM-T15234

  • HIF-1/2α-IN-2
    Targetmol
    + Info

    HIF-1/2α-IN-2

    CAS:
    <p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>
    Formula:C16H11FN4O2S
    Colore e forma:Solid
    Peso molecolare:342.35

    Ref: TM-T61102

  • THS-044
    Targetmol
    + Info

    THS-044

    CAS:
    <p>THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity</p>
    Formula:C11H12F3N3O3
    Purezza:99.89%
    Colore e forma:Solid
    Peso molecolare:291.23

    Ref: TM-T13925

  • KCN1
    Targetmol
    + Info

    KCN1

    CAS:
    <p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>
    Formula:C26H27NO5S
    Colore e forma:Solid
    Peso molecolare:465.56

    Ref: TM-T68324

  • TM6089
    Targetmol
    + Info

    TM6089

    CAS:
    <p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>
    Formula:C13H14N4O3S
    Purezza:99.70%
    Colore e forma:Solid
    Peso molecolare:306.34

    Ref: TM-T17105

  • HIF-1α inhibitor-1
    Targetmol
    + Info

    HIF-1α inhibitor-1

    CAS:
    <p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>
    Formula:C15H11N3O4
    Colore e forma:Solid
    Peso molecolare:297.27

    Ref: TM-T71661

  • KRH102140
    Targetmol
    + Info

    KRH102140

    CAS:
    <p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>
    Formula:C25H24FNO
    Purezza:98.31% - 99.61%
    Colore e forma:Solid
    Peso molecolare:373.46

    Ref: TM-T68511

  • HIF-2α-IN-3
    Targetmol
    + Info

    HIF-2α-IN-3

    CAS:
    <p>HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.</p>
    Formula:C12H6ClN5O5
    Purezza:98.11%
    Colore e forma:Solid
    Peso molecolare:335.66

    Ref: TM-T11562

  • TC-S 7009
    Targetmol
    + Info

    TC-S 7009

    CAS:
    <p>TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization &amp; gene expression.</p>
    Formula:C12H6ClFN4O3
    Purezza:99.46% - 99.71%
    Colore e forma:Solid
    Peso molecolare:308.65

    Ref: TM-T17009

  • HIF-2α-IN-13
    Targetmol
    + Info

    HIF-2α-IN-13

    CAS:
    <p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>
    Formula:C15H14ClF4NO2
    Colore e forma:Solid
    Peso molecolare:351.72

    Ref: TM-T88052

  • PHD-IN-2
    Targetmol
    + Info

    PHD-IN-2

    CAS:
    <p>PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of</p>
    Formula:C26H27N7O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:501.54

    Ref: TM-T79798

  • Prolyl Hydroxylase inhibitor 1
    Targetmol
    + Info

    Prolyl Hydroxylase inhibitor 1

    CAS:
    <p>Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).</p>
    Formula:C19H18ClN5O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:415.83

    Ref: TM-T12547

  • PHD2-IN-1
    Targetmol
    + Info

    PHD2-IN-1

    CAS:
    <p>PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].</p>
    Formula:C21H23ClN4O5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:446.88

    Ref: TM-T79241