ROR
I recettori orfani correlati all'acido retinoico (RORs) sono recettori nucleari che regolano vari processi fisiologici, tra cui il ritmo circadiano, la risposta immunitaria e il metabolismo. Gli inibitori dei RORs sono di grande interesse nello studio delle malattie autoimmuni, dei disturbi metabolici e del cancro, poiché possono modulare l'espressione genica e influenzare le funzioni cellulari. Presso CymitQuimica, offriamo inibitori dei RORs per supportare la tua ricerca in immunologia, endocrinologia e oncologia.
Trovati 47 prodotti di "ROR"
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ROR1-IN-2
ROR1-IN-2 (compound 9I) is a potent and selective inhibitor of ROR1. It exhibits antiproliferative activity in various cancer cell lines and significantly inhibits tumor growth in vivo.Formula:C30H27N3O4Colore e forma:SolidPeso molecolare:493.20016Antitumor agent-127
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide that demonstrates nanomolar binding affinity to ROR1 and shows relatively good internalization in 786-O and MDA-MB-231 tumor cell lines.Formula:C86H107N15O18SPeso molecolare:1669.76392Bevurogant
CAS:Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.
Formula:C26H28N8O3SPurezza:99.32%Colore e forma:SolidPeso molecolare:532.62XY039
XY039 (compound 13e) is an RORγ inverse agonist with an IC50 value of 0.55 μM. XY039 induces cell apoptosis and exhibits antiproliferative activity both in vivo and in vitro.Formula:C23H19F5N2O4S2Peso molecolare:546.07064ROR1 ligand-1
ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.Formula:C23H30BrN7Colore e forma:SolidPeso molecolare:484.44RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.
Formula:C27H37NO5SColore e forma:SolidPeso molecolare:487.651TMP-778
CAS:TMP-778 is a selective inverse agonist of RORγt.Formula:C31H30N2O4Purezza:99.68%Colore e forma:SolidPeso molecolare:494.58RORγ agonist 2
RORγ agonist2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. It significantly inhibits tumor growth in an MC38 tumor mouse model with the same genetic background.Colore e forma:Odour SolidRORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Formula:C23H15Cl2F3N4O3SPurezza:98%Colore e forma:SolidPeso molecolare:555.36RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Formula:C35H60N2O2Purezza:98%Colore e forma:SolidPeso molecolare:540.86TMP920
CAS:TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Formula:C29H30N2O3Purezza:98%Colore e forma:SolidPeso molecolare:454.56XY018
CAS:XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.Formula:C23H15F7N2O4Purezza:99.95% - 99.96%Colore e forma:SolidPeso molecolare:516.37GSK2981278
CAS:GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).Formula:C25H35NO5SPurezza:99.31% - 99.67%Colore e forma:SolidPeso molecolare:461.61SR1001
CAS:SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Formula:C15H13F6N3O4S2Purezza:98.93%Colore e forma:SolidPeso molecolare:477.4Cedirogant
CAS:Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.Formula:C24H20Cl3F3N2O3Purezza:99.20%Colore e forma:SolidPeso molecolare:547.78Ref: TM-T9635
1mg81,00€5mg167,00€10mg259,00€25mg470,00€50mg703,00€100mg1.044,00€200mg1.404,00€1mL*10mM (DMSO)197,00€SR3335
CAS:SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Formula:C13H9F6NO3S2Purezza:99.77%Colore e forma:SolidPeso molecolare:405.34Ref: TM-T5160
1mg34,00€5mg74,00€10mg119,00€25mg233,00€50mg371,00€100mg595,00€200mg833,00€1mL*10mM (DMSO)82,00€SR0987
CAS:SR0987 is a RORγt agonist,Formula:C16H10ClF6NO2Purezza:99.43%Colore e forma:SolidPeso molecolare:397.7Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Formula:C27H23F6NO6SPurezza:99.92%Colore e forma:SolidPeso molecolare:603.53Ref: TM-TQ0007
1mg66,00€5mg130,00€10mg178,00€25mg313,00€50mg447,00€100mg620,00€1mL*10mM (DMSO)167,00€S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Formula:C26H25F3N2O4SPurezza:99.24% - 99.31%Colore e forma:SolidPeso molecolare:518.55Ref: TM-T16832
1mg54,00€5mg118,00€10mg178,00€25mg318,00€50mg445,00€100mg627,00€500mg1.251,00€1mL*10mM (DMSO)135,00€SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Formula:C17H10F9NO2Purezza:99.58%Colore e forma:SolidPeso molecolare:431.25Ref: TM-T4594
1mg39,00€2mg52,00€5mg85,00€10mg109,00€25mg215,00€50mg349,00€100mg517,00€1mL*10mM (DMSO)87,00€
