Transferasi
Le transferasi sono una grande classe di enzimi che catalizzano il trasferimento di gruppi funzionali, come gruppi metile, glicosile e fosfato, da una molecola all'altra. Gli inibitori delle transferasi sono utilizzati per studiare un'ampia gamma di processi biologici, tra cui la trasduzione del segnale, il metabolismo e l'espressione genica. Questi inibitori sono strumenti essenziali in ambiti di ricerca come il cancro, le malattie metaboliche e l'epigenetica, dove è implicata una disfunzione dell'attività delle transferasi. Presso CymitQuimica offriamo una selezione completa di inibitori delle transferasi per supportare la tua ricerca in enzimologia, segnalazione cellulare e meccanismi patologici.
Trovati 37 prodotti per "Transferasi".
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Cycloleucine
CAS:Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM.Formula:C6H11NO2Purezza:99.90%Colore e forma:SolidPeso molecolare:129.16Opicapone
CAS:Opicapone (BIA 9-1067), a potent COMT inhibitor for Parkinson's studies, lowers cell ATP (IC50: 98 μM).Formula:C15H10Cl2N4O6Purezza:98.17% - 99.36%Colore e forma:SolidPeso molecolare:413.17Sinbaglustat
CAS:Sinbaglustat (OGT2378), an oral N-alkyl iminosugar, inhibits GCS/GBA2 and treats lysosomal storage and neurodegenerative disorders.Formula:C11H23NO4Purezza:99.97%Colore e forma:SolidPeso molecolare:233.3Ref: TM-T40542
1mg69,00€1mL*10mM (DMSO)140,00€5mg156,00€10mg225,00€25mg359,00€50mg487,00€100mg648,00€200mg875,00€R1-11
R1-11 is an indole-based ICMT inhibitor with an IC50 of 0.6 μM, exhibiting anticancer properties. It inhibits MDA-MB231 and PC3 cells with IC50 values of 2.2 μM and 2.0 μM, respectively.Formula:C25H37N5Colore e forma:SolidPeso molecolare:407.3049J6-3
J6-3 is an inhibitor of ICMT with an IC50 of 0.6 μM, exhibiting anticancer properties. The compound inhibits MDA-MB231 cells with an IC50 of 3.4 μM.Formula:C28H40N2Colore e forma:SolidPeso molecolare:404.31915Squalene synthase-IN-2
Squalene synthase-IN-2 (compound isomer A-(1S, 3R)-14i) is an orally active inhibitor of squalene synthase, with IC50 values of 3.4 nM for squalene synthase and 99 nM for cholesterol synthesis enzymes. Squalene synthase-IN-2 effectively reduces plasma cholesterol and triglycerides.Formula:C31H39ClN2O6Colore e forma:SolidPeso molecolare:570.24966Histamine glutarimide
CAS:Histamine glutarimide is a novel QPCT inhibitor that targets inflammatory processes like eosinophil migration, showing anti-asthmatic effects in animal models.Formula:C10H13N3O2Purezza:99.79%Colore e forma:SolidPeso molecolare:207.23FUT8-IN-1
FUT8-IN-1 (Compound 37) is an inhibitor of α-1,6-fucosyltransferase (FUT8), with a dissociation constant (KD) of 49 nM and an IC50 around 50 µM. In the presence of FUT8, FUT8-IN-1 forms a highly active naphthoquinone imine intermediate, thereby inhibiting FUT8's enzymatic activity.Formula:C23H25ClN2OColore e forma:SolidPeso molecolare:380.91β-1,4-GALT1-IN-1
β-1,4-GALT1-IN-1 (Compound 6) is a β-1,4-GALT1 inhibitor with an IC50 value of 6.2 μM. It is applicable in studying various pathological conditions, including cancer, autoimmune diseases, and viral infections.Formula:C29H23NO10Colore e forma:SolidPeso molecolare:545.494L-739750 2HCl
L-739750 2HCl is a potent inhibitor of peptidomimetic farnesyltransferase, a novel pseudopeptide mimetic with potential anticancer activity.Formula:C23H41Cl2N3O6S2Purezza:98.69% - 99.16%Colore e forma:SoildPeso molecolare:590.62FTI-277
CAS:FTI-277, an FTase inhibitor, blocks H-Ras/K-Ras signaling and HDV infection; mimics Ras CAAX peptide.Formula:C22H29N3O3S2Purezza:99.63%Colore e forma:White SolidPeso molecolare:447.61BAY-593
CAS:BAY-593 is an orally active GGTase-I inhibitor capable of blocking YAP1/TAZ signaling in vivo, exhibiting antitumor activity.Formula:C26H31F3N2O3Colore e forma:SolidPeso molecolare:476.53Ervogastat
CAS:Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor.Formula:C21H21N5O4Purezza:99.97%Colore e forma:White SolidPeso molecolare:407.42Ref: TM-T9186
1mg123,00€5mg290,00€1mL*10mM (DMSO)301,00€10mg485,00€25mg782,00€50mg1.063,00€100mg1.431,00€Tipifarnib
CAS:Tipifarnib (IND 58359), a quinolinone, inhibits farnesyl transferase, blocks Ras activation, arrests cell growth, and curbs angiogenesis.Formula:C27H22Cl2N4OPurezza:97.1% - 99.22%Colore e forma:Off-White To Pale Beige SolidPeso molecolare:489.4CP-609754
CAS:CP-609754 shows selective inhibition of farnesyltransferase.Formula:C29H22ClN3O2Purezza:99.86% - 99.87%Colore e forma:SolidPeso molecolare:479.96Ref: TM-T38050
1mg52,00€5mg110,00€1mL*10mM (DMSO)111,00€10mg177,00€25mg301,00€50mg425,00€100mg605,00€200mg797,00€Entacapone
CAS:Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).Formula:C14H15N3O5Purezza:98.80% - >99.99%Colore e forma:Yellow Crystalline SolidPeso molecolare:305.29Ref: TM-T2216
5mg34,00€1mL*10mM (DMSO)35,00€10mg49,00€25mg75,00€50mg90,00€100mg137,00€200mg197,00€500mg333,00€PD 128042
CAS:PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor.Formula:C23H39NO4Purezza:99.79%Colore e forma:SolidPeso molecolare:393.56Tipifarnib (S enantiomer)
CAS:Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).Formula:C27H22Cl2N4OPurezza:99.05%Colore e forma:SolidPeso molecolare:489.4Ref: TM-T17102
1mg49,00€5mg102,00€1mL*10mM (DMSO)109,00€10mg163,00€25mg284,00€50mg409,00€100mg577,00€200mg778,00€Ibiglustat
CAS:Ibiglustat (GZ402671) inhibits Glucosylceramide synthase, may treat Fabry disease by preventing GL-3 synthesis.Formula:C20H24FN3O2SPurezza:97.97% - 98.81%Colore e forma:White SolidPeso molecolare:389.49Nitecapone
CAS:Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)Formula:C12H11NO6Purezza:98.39%Colore e forma:SolidPeso molecolare:265.223-O-Methyltolcapone
CAS:3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor.Formula:C15H13NO5Purezza:98%Colore e forma:SolidPeso molecolare:287.27PDMP hydrochloride
CAS:PDMP, a glucosylceramide synthase inhibitor with 4 stereoisomers, acts at 0.8μM; D-threo enantiomer also blocks lactosylceramide synthesis.Formula:C23H39ClN2O3Colore e forma:SolidPeso molecolare:427.03SAHO
CAS:SAHO is a COMT inhibitor with an IC50 value of 860 μM, used in methylation reaction regulator research.Formula:C14H20N6O6SPurezza:99.78%Colore e forma:White SolidPeso molecolare:400.41P-3FAX-Neu5Ac
CAS:P-3FAX-Neu5Ac is a sialic acid analog and a sialyltransferase inhibitor.Formula:C22H30FNO14Purezza:97.08%Colore e forma:White SolidPeso molecolare:551.47Lucerastat
CAS:Lucerastat（NBDGJ） is an orally available inhibitor of GCS for Fabry disease by reducing harmful substrates.. GCS is a key enzyme in sphingolipid synthesiss.Formula:C10H21NO4Purezza:98%Colore e forma:White SolidPeso molecolare:219.28Prenyl-IN-1
CAS:Prenyl-IN-1 inhibits prenylation selectively, counters oxidative stress in Parkinson's.Formula:C28H24ClN5O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:497.98α-2,3-sialyltransferase-IN-1
CAS:α-2,3-sialyltransferase-IN-1 is a noncompetitive inhibitor of α-2,3-sialyltransferase(IC50 of 6 μM).Formula:C28H45NO6Purezza:98% - 98%Colore e forma:Transparent LiquidPeso molecolare:491.66Lith-O-Asp
CAS:Lith-O-Asp is a sialyltransferase inhibitor; Ki=1.3 μM; reduces sialylation; inhibits cancer cell invasion; metastasis research.Formula:C28H45NO6Colore e forma:White SolidPeso molecolare:491.66Ibiglustat (L-Malic acid)
CAS:Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase.Formula:C24H30FN3O7SPurezza:99.54%Colore e forma:SolidPeso molecolare:523.57Ref: TM-T11599
1mg37,00€2mg50,00€5mg96,00€1mL*10mM (DMSO)100,00€10mg128,00€25mg208,00€50mg310,00€100mg444,00€200mg618,00€Miglustat hydrochloride
CAS:Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I GaucherFormula:C10H22ClNO4Purezza:99.85%Colore e forma:SolidPeso molecolare:255.74Ref: TM-TQ0155
1mg38,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg130,00€25mg245,00€50mg385,00€100mg557,00€200mg790,00€OSMI-1
CAS:OSMI-1: cell-permeable OGT inhibitor, blocks O-GlcNAcylation (IC50: 2.7 μM), no effect on other cell glycans.Formula:C28H25N3O6S2Purezza:96.79% - 99.66%Colore e forma:SolidPeso molecolare:563.64FGTI-2734
CAS:FGTI-2734, a dual FT/GGT-1 inhibitor (IC50: 250/520 nM), blocks KRAS membrane binding and curbs KRAS-driven pancreatic cancer.Formula:C26H31FN6O2SPurezza:99.69%Colore e forma:SolidPeso molecolare:510.63Ref: TM-T11282
1mg49,00€5mg113,00€1mL*10mM (DMSO)129,00€10mg178,00€25mg371,00€50mg557,00€100mg792,00€Glucosylceramide synthase-IN-4
CAS:Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].Formula:C22H18F5N3O3Colore e forma:SolidPeso molecolare:467.39PF-07202954
CAS:PF-07202954 is a DGAT2 inhibitor with a long half-life. reduce the triglyceride content in the liver of rats fed with a Western diet, NASH.Formula:C22H23FN6O3Purezza:98.99%Colore e forma:Yellow SolidPeso molecolare:438.45BMS-214662 mesylate
CAS:BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.Formula:C26H27N5O5S3Colore e forma:SolidPeso molecolare:585.718Darlifarnib
CAS:Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.Formula:C29H20N6OColore e forma:SolidPeso molecolare:468.509ICMT-IN-55
CAS:ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].Formula:C22H26F3NO2Colore e forma:SolidPeso molecolare:393.44
