Deidrogenasi
Le deidrogenasi sono enzimi coinvolti nelle reazioni di ossidoriduzione delle vie metaboliche, svolgendo un ruolo centrale nella produzione di energia e nella respirazione cellulare. Questi enzimi sono cruciali per processi come il ciclo dell'acido citrico, la glicolisi e l'ossidazione degli acidi grassi. Gli inibitori delle deidrogenasi sono strumenti importanti nello studio delle malattie metaboliche, del cancro e dello stress ossidativo. Presso CymitQuimica, offriamo una selezione completa di inibitori delle deidrogenasi per supportare la tua ricerca in metabolismo, biologia del cancro e biochimica.
Trovati 302 prodotti di "Deidrogenasi"
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Antiproliferative agent-13
CAS:Antiproliferative agent-13 is a compound with antiproliferative activity.Formula:C20H18N2O6Purezza:99.723%Colore e forma:SolidPeso molecolare:382.37Octanoyl Coenzyme A (sodium salt)
Octanoyl Coenzyme A (sodium salt) inhibits citrate synthase and glutamate dehydrogenase with an IC50 of 0.4–1.6 mM.Formula:C29H49N7NaO17P3SColore e forma:SolidPeso molecolare:915.71BMS-770767
CAS:BMS-770767 is a novel 11-betahydroxysteroid dehydrogenase type I (11ß-HSD1) inhibitor.Formula:C19H18ClN3O2Colore e forma:SolidPeso molecolare:355.82DHODH-IN-16
CAS:DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).Formula:C24H25FN4O3Purezza:99.64%Colore e forma:SolidPeso molecolare:436.48HSD17B13-IN-89
CAS:HSD17B13-IN-89 (206) acts as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13) and demonstrates potent activity with an IC 50 value of less than 0.1 μM for Estradiol. It is commonly utilized in research related to Nonalcoholic Fatty Liver Diseases (NAFLD) [1].Formula:C23H13Cl2F4N3O3Peso molecolare:526.27PTOTAC HSD17B13 degrader 1
CAS:PTOTAC HSD17B13 Degrader 1, a PROTAC designed to target 17β-HSD 13 (HSD17B13), incorporates several key components. These include the PROTAC target protein ligand HSD17B13 Degrader 2, the PROTAC Linker tert-Butyl 5-bromoisoindoline-2-carboxylate, and the E3 ubiquitin ligase ligand E3 Ligase Ligand 31. Notably, the conjugate formed by the E3 ubiquitin ligase ligand and the linker is recognized as E3 Ligase Ligand-linker Conjugate 114.Formula:C45H45ClF3N7O5Colore e forma:SolidPeso molecolare:856.33Crelosidenib
CAS:Crelosidenib is a potent and selective mutant IDH inhibitor for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutases.Formula:C28H36N6O3Purezza:98.54%Colore e forma:SolidPeso molecolare:504.6211β-HSD1 inibitor 19
CAS:3-chloro-4-sulfonyl-Benzonitrile inhibits hHSD1/mHSD1, IC50: 16nM/10nM.Formula:C19H16ClF4N3O2SPurezza:99.58%Colore e forma:SoildPeso molecolare:461.86SKI2852
CAS:SKI2852 is an 11β-HSD1 inhibitor that improves metabolic syndrome in diabetic mouse models.Formula:C27H34FN5O4SPurezza:99.89%Colore e forma:SolidPeso molecolare:543.65DHODH-IN-18
CAS:DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).Formula:C21H16ClF5N6O4Colore e forma:SolidPeso molecolare:546.84MTHFD2-IN-4 sodium
MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].Formula:C26H21F6N2NaO5Colore e forma:SolidPeso molecolare:578.44D34-919
CAS:D34-919 is a potent inhibitor of the ALDH1A3-PKM2 interaction, effectively inhibiting the ALDH1A3-mediated tetramerization enhancement of PKM2. Treatment mediated by D34-919 both in vitro and in vivo enhances and restores apoptosis and sensitivity in glioblastoma (GBM) cells induced by radiochemotherapy.Formula:C22H27N5OSPeso molecolare:409.55LDHA-IN-8
CAS:LDHA-IN-8, an inhibitor, inhibits the proliferation of pancreatic and lung cancer cells, decreasing the intracellular lactate content and increasing ROS levels.Formula:C15H14N4O2Purezza:99.73%Colore e forma:SolidPeso molecolare:282.3MTHFD2-IN-1
<p>MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>Formula:C24H21NO6Colore e forma:SolidPeso molecolare:419.43MTHFD2-IN-4
MTHFD2-IN-4, a tricyclic coumarin derivative, serves as a potent inhibitor of MTHFD2 and has applications in cancer research [1].Formula:C26H21F6N2O5Colore e forma:SolidPeso molecolare:555.45DHODH-IN-23
CAS:<p>DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.</p>Formula:C24H21ClFNO4Purezza:99.7%Colore e forma:SolidPeso molecolare:441.88IGUANA-1
CAS:<p>IGUANA-1 is a highly efficient and selective ALDH1B1 inhibitor that inhibits the growth of colorectal cancer cells and colorectal cancer cell-derived organoids.</p>Formula:C27H26ClN3O4Purezza:99.08%Colore e forma:SolidPeso molecolare:491.97D-Lactate dehydrogenase
CAS:D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.Colore e forma:SolidHSD17B13-IN-71
CAS:HSD17B13-IN-71 (Compound 149), an effective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), displays potent activity with an IC 50 value of ≤ 0.1 μM against estradiol. This compound is applicable in the study of various disorders including liver diseases, metabolic diseases, and cardiovascular conditions such as NAFLD or NASH, in addition to drug-induced liver injury (DILI) [1].Formula:C25H16Cl2F5N3O4Peso molecolare:588.31hDHODH-IN-17
hDHODH-IN-17 (Compound 10) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH), with an IC50 value of 0.188 μM. It fits well with the hDHODH active site and interacts effectively with amino acid residues. hDHODH-IN-17 is a potential broad-spectrum antiviral drug.11β-HSD1 inibitor 17
CAS:11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).Formula:C22H20F3N3O2SPurezza:99.26% - 99.72%Colore e forma:SoildPeso molecolare:447.47DSM1465
DSM1465 (Compound 82) is a potent and selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM. It inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM and demonstrates significant in vivo efficacy in humanized P. falciparum mouse models.Formula:C17H12ClF6N5O2Colore e forma:SolidPeso molecolare:467.753PDK-IN-1
CAS:PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.Formula:C20H16BrN7OColore e forma:SolidPeso molecolare:450.29Necroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Formula:C12H17NOSPurezza:99.85%Colore e forma:SoildPeso molecolare:223.3311β-HSD1-IN-11
CAS:11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13Formula:C15H11F3O3SPurezza:99.61%Colore e forma:SoildPeso molecolare:328.31MTHFD2-IN-2
MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Formula:C22H18N4O5Colore e forma:SolidPeso molecolare:418.4Glucose dehydrogenase
CAS:Glucose dehydrogenase (GDH) is a redox enzyme typically occurring as dimeric or tetrameric proteins. GDH utilises external NAD or NADP to oxidise glucose .ALDH1A2-IN-1
CAS:ALDH1A2-IN-1 is a reversible active-site-directed ALDH1A2 inhibitor preventing spermatogenesis, useful in male contraceptive research.Formula:C21H26N4O4SPurezza:99.51%Colore e forma:SolidPeso molecolare:430.52DSM265
CAS:DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity.DSM265 can be used for the treatment of malaria infections.Formula:C14H12F7N5SPurezza:99.79%Colore e forma:SolidPeso molecolare:415.33DSM502
CAS:DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.Formula:C16H16F3N3OPurezza:99.52%Colore e forma:SolidPeso molecolare:323.31Aldehyde dehydrogenase (NAD(P))
CAS:<p>ALDH catalyzes oxidation of aldehydes to acids, reducing NAD(P) to NAD(P)H, helping alleviate aldehyde stress.</p>Colore e forma:SolidKetogestin
CAS:Ketogestin is a progestational steroid and an inhibitor of enzyme 11β-hydroxysteroid dehydrogenase, and a weak negative modulator of GABAA receptors.Formula:C21H28O3Purezza:99.19%Colore e forma:SolidPeso molecolare:328.452-Bromoacetamide
CAS:2-Bromoacetamide (α-Bromoacetamide) is a class of disinfection by-products that exhibit developmental toxicity in animals.Formula:C2H4BrNOPurezza:99.83%Colore e forma:SolidPeso molecolare:137.96BMS-566419
CAS:BMS-566419: Acridinone-based IMPDH inhibitor for studying graft rejection.Formula:C28H30FN5O2Colore e forma:SolidPeso molecolare:487.57PKUMDL-WQ-2201
CAS:PKUMDL-WQ-2201 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with Anti-tumor Activity, it binds to site II.Formula:C15H14ClN3O3SColore e forma:SolidPeso molecolare:351.81ALDH1A3-IN-1
CAS:ALDH1A3-IN-1 (Compound 14) is a potent inhibitor of ALDH1A3 which can be used in prostate cancer research (IC50 = 0.63 μM; Ki = 0.46 μM) [1].Formula:C13H18BrNOColore e forma:SolidPeso molecolare:284.19PS10
CAS:PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.Formula:C14H13NO6SPurezza:99.01%Colore e forma:SolidPeso molecolare:323.32ALDH3A1-IN-1
CAS:ALDH3A1-IN-1 (Compound 18) is a potent inhibitor of ALDH3A1 with IC50 of 1.61 μM, outperforms DEAB in prostate cancer cells.Formula:C13H18N2O3Purezza:99.86%Colore e forma:SolidPeso molecolare:250.294-Isopropoxybenzaldehyde
CAS:ALDH1A3-IN-3 inhibits ALDH1A3 (IC50: 0.26 μM), acts on ALDH3A1, and is used in prostate cancer research.Formula:C10H12O2Purezza:99.00%Colore e forma:SolidPeso molecolare:164.2ABT-384
CAS:ABT-384 is a high-affinity, selective 11β-HSD1 inhibitor capable of suppressing hepatic and central nervous system HSD-1 activity for depressive disorder.Formula:C25H34F3N5O2Purezza:99.863%Colore e forma:SolidPeso molecolare:493.58VER-246608
CAS:VER-246608 inhibits PDK (IC50: 35-91 nM), boosts PDC, reduces glycolysis, causes cancer cell cytostasis, and enhances doxorubicin effects.Formula:C28H23ClF2N4O4Purezza:98.5%Colore e forma:SolidPeso molecolare:552.96Brequinar
CAS:Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.Formula:C23H15F2NO2Purezza:99.1% - 99.57%Colore e forma:SolidPeso molecolare:375.37BVT 2733
CAS:<p>BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.</p>Formula:C17H21ClN4O3S2Purezza:98% - 99.64%Colore e forma:SolidPeso molecolare:428.96AGI-6780
CAS:AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.Formula:C21H18F3N3O3S2Purezza:98.19% - 99.7%Colore e forma:SolidPeso molecolare:481.51(E/Z)-Teriflunomide
CAS:(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.Formula:C12H9F3N2O2Purezza:99.49% - 99.76%Colore e forma:White SolidPeso molecolare:270.21Nitrofurazone
CAS:Nitrofurazone (Furacilin) is a topical anti-infective agent effective against gram-negative and gram-positive bacteria.Formula:C6H6N4O4Purezza:99.87%Colore e forma:Pale Yellow Needles Solution) 6 0 - 6 5 Alkaline Solutions Are Dark Orange (Ntp 1992)Peso molecolare:198.14Galloflavin
CAS:Galloflavin is a lactate dehydrogenase inhibitor. Galloflavin inhibits both human LDH isoforms (type A and type B).Cost-effective and quality-assured.Formula:C12H6O8Purezza:96.24% - 97.47%Colore e forma:SolidPeso molecolare:278.17NCT-505
CAS:NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 withFormula:C27H28FN5O3SPurezza:99.93%Colore e forma:SolidPeso molecolare:521.61R162
CAS:R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.Formula:C17H12O3Purezza:96.21% - 98.15%Colore e forma:SolidPeso molecolare:264.28PfDHODH-IN-2
CAS:PfDHODH-IN-2: powerful antimalarial, blocks PfDHODH (IC50: 1.11 μM), for malaria research.Formula:C13H12ClNO3SPurezza:98.9%Colore e forma:SolidPeso molecolare:297.76
