Fosfolipasi
Le fosfolipasi sono un gruppo di enzimi che idrolizzano i fosfolipidi in acidi grassi e altre sostanze lipofile, svolgendo un ruolo critico nella biologia delle membrane e nella generazione di molecole segnalatrici. Gli inibitori delle fosfolipasi vengono utilizzati per studiare il loro ruolo nelle malattie infiammatorie, nei disturbi cardiovascolari e nella neurodegenerazione. Questi inibitori sono anche preziosi per esplorare le vie di segnalazione lipidica e le loro implicazioni nei meccanismi delle malattie. Presso CymitQuimica, offriamo una varietà di inibitori delle fosfolipasi per supportare la tua ricerca in infiammazione, metabolismo lipidico e segnalazione cellulare.
Trovati 82 prodotti di "Fosfolipasi"
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Omeprazole
CAS:Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor.Formula:C17H19N3O3SPurezza:98.43% - 98.48%Colore e forma:White SolidPeso molecolare:345.42Niflumic acid
CAS:<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>Formula:C13H9F3N2O2Purezza:99.47%Colore e forma:SolidPeso molecolare:282.22Tris(2,4-di-tert-butylphenyl)phosphate
CAS:Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) inhibits secretory phospholipase A2 (sPLA2) with anti-inflammatory effect. Cost-effective and quality-assured.Formula:C42H63O4PPurezza:99.73%Colore e forma:SolidPeso molecolare:662.92Lp-PLA2-IN-1
CAS:<p>Lp-PLA2-IN-1 suppresses Lp-PLA2, aiding in treating atherosclerosis and Alzheimer's.</p>Formula:C21H17F5N4O3Purezza:99.60%Colore e forma:SolidPeso molecolare:468.38Lansoprazole
CAS:<p>Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON</p>Formula:C16H14F3N3O2SPurezza:99.18% - 99.84%Colore e forma:White Crystalline PowderPeso molecolare:369.36ML349
CAS:ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).Formula:C23H22N2O4S2Purezza:99.59% - 99.88%Colore e forma:SolidPeso molecolare:454.561-Myristoyl-2-Linoleoyl-sn-glycero-3-PC
CAS:1-Myristoyl-2-Linoleoyl-sn-glycero-3-PC is a phospholipid identified in human plasma, characterized by the presence of Myristic acid and Linoleic acid at the sn-1 and sn-2 positions, respectively.Formula:C40H76NO8PColore e forma:SolidPeso molecolare:730.01VU533
CAS:VU533 is a NAPE-PLD activator, EC50=0.30 µM, boosts macrophage activity, potential in cardiometabolic diseases.Formula:C21H22FN3O3S2Purezza:99.87%Colore e forma:SolidPeso molecolare:447.55AACOCF3
CAS:AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid.Formula:C21H31F3OPurezza:99% - 99%Colore e forma:Yellow LiquidPeso molecolare:356.47A3373
CAS:A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) ofFormula:C17H9F7N2OPurezza:98%Colore e forma:SoildPeso molecolare:390.26Compound 48/80 trihydrochloride
CAS:<p>Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。</p>Formula:C32H48Cl3N3O3Purezza:98%Colore e forma:SolidPeso molecolare:629.1ASM-IN-3
CAS:ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.Formula:C17H13ClN2O4Colore e forma:SolidPeso molecolare:344.75BIRM 271
CAS:<p>BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils.</p>Formula:C21H25N3OPurezza:99.64%Colore e forma:SoildPeso molecolare:335.44SB-435495
CAS:SB-435495 is a compound characterized by its potent, selective, reversible, and non-covalent inhibition of Lp-PLA2, demonstrating an IC50 value of 0.06 nM.Formula:C38H40F4N6O2SPurezza:99.07%Colore e forma:SolidPeso molecolare:720.82DPTIP hydrochloride
CAS:DPTIP hydrochloride is a potent inhibitor of neutral sphingomyelinase (N-SMase 2) that can cross the blood-brain barrier. It acts as an exosome inhibitor with an IC50 value of 30 nM.Formula:C21H19ClN2O3SColore e forma:SolidPeso molecolare:414.91PLA2-IN-1
<p>PLA2-IN-1 (Compound 7) is a potent and selective inhibitor of phospholipase A (PLA2) with an IC50 value of 1 nM. It effectively inhibits PLA2-induced coagulation disorders in vitro and shows potential for use as an antidote for snake bites caused by cobra venom.</p>Colore e forma:Odour SolidnSMase2-IN-1
nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with a potent IC50 value of 0.13 ± 0.06 μM.Formula:C12H17N5OPurezza:98%Colore e forma:SolidPeso molecolare:247.3LEI110
CAS:LEI110 inhibits PLA2G16 and HRASLS enzymes, Ki 20 nM, selectively targets related thiol hydrolases.Formula:C25H23F3N2O3Purezza:98.66% - 98.8%Colore e forma:SolidPeso molecolare:456.46A4333
<p>A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2.</p>Purezza:98%Colore e forma:Odour SolidDPTIP
CAS:<p>DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.</p>Formula:C21H18N2O3SPurezza:99.88%Colore e forma:SolidPeso molecolare:378.44BMS493
CAS:BMS493 is an inverse agonist of RAR that inhibits retinoic acid-induced differentiation and inhibits the increase in phospholipase A2 activity.Formula:C29H24O2Purezza:99.12% - >99.99%Colore e forma:SolidPeso molecolare:404.5Bromoenol lactone
CAS:NeurokininBromoenol lactone ((6E)-Bromoenol lactone) is an iPLA2β and serine protease inhibitor that attenuates nicotine-induced breast cancer cell proliferation.Formula:C16H13BrO2Colore e forma:SolidPeso molecolare:317.18PACOCF3
CAS:PACOCF3, a phospholipase A2 inhibitor, hinders Ca2+ signaling with an IC50 of 3.8 μM in renal cells.Formula:C17H31F3OPurezza:99.93%Colore e forma:SolidPeso molecolare:308.42MJ33 lithium salt
CAS:<p>MJ33 lithium salt is an inhibitor of NADPH oxidase type 2-mediated ROS generation, inhibits PLA2 activity, and can be used to study acute lung injury.</p>Formula:C22H43F3LiO6PPurezza:99%Colore e forma:SolidPeso molecolare:498.48LEI-401
CAS:LEI-401 is a NAPE-PLD inhibitor.LEI-401 reduces the level of n-acyl ethanolamines in the brain of free-ranging mice and modulates their emotional behaviour.Formula:C24H31N5O2Purezza:99.79% - 99.79%Colore e forma:SolidPeso molecolare:421.54ML-211
CAS:<p>ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM)</p>Formula:C25H30N4O2Purezza:97.07%Colore e forma:SolidPeso molecolare:418.53N-(p-amylcinnamoyl) Anthranilic Acid
CAS:N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.Formula:C21H23NO3Purezza:99.35% - 99.67%Colore e forma:SolidPeso molecolare:337.41Rhamnetin
CAS:<p>Rhamnetin (beta-Rhamnocitrin), a quercetin derivative found in Coriandrum sativum, has antioxidant and anti-inflammatory activities.</p>Formula:C16H12O7Purezza:99.61% - 99.905%Colore e forma:SolidPeso molecolare:316.26hnps-PLA Inhibitor
CAS:<p>Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).</p>Formula:C21H21N3O4Purezza:99.68%Colore e forma:SolidPeso molecolare:379.41Varespladib
CAS:Varespladib (LY315920) inhibits hnsPLA2 effectively (IC50=7 nM), studied for sickle cell, VOC, and acute coronary syndrome.Formula:C21H20N2O5Purezza:99.97%Colore e forma:SolidPeso molecolare:380.39BAPTA
CAS:BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.Formula:C22H24N2O10Purezza:97.21% - ≥95%Colore e forma:White SolidPeso molecolare:476.43Rapanone
CAS:Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.Formula:C19H30O4Purezza:99.56%Colore e forma:SolidPeso molecolare:322.44U-73343
CAS:<p>U-73343 is an inactive analog of U-73122 and can be used as a negative control. U-73122 dose-dependently inhibits acid secretion irrespective of the stimulant.</p>Formula:C29H42N2O3Purezza:99.06%Colore e forma:SolidPeso molecolare:466.66Tanshinone I
CAS:Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.Formula:C18H12O3Purezza:98.31% - 98.70%Colore e forma:SolidPeso molecolare:276.29ML348
CAS:<p>ML348 (GNF-Pf-1127) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).</p>Formula:C18H17ClF3N3O3Purezza:99% - 99.88%Colore e forma:SolidPeso molecolare:415.79FIPI
CAS:<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Formula:C23H24FN5O2Purezza:97.21% - 98.68%Colore e forma:SolidPeso molecolare:421.47ML-298
CAS:ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).Formula:C22H23F3N4O2Purezza:99.35%Colore e forma:SolidPeso molecolare:432.441-Naphthaleneacetic acid
CAS:1-Naphthaleneacetic acid, an auxin-like synthetic plant hormone, boosts rooting in horticulture.Formula:C12H10O2Purezza:98.67%Colore e forma:Needles From Water White To Off White CrystalsPeso molecolare:186.21ST271
CAS:<p>ST271 is an effective protein tyrosine kinase (PTK) inhibitor.</p>Formula:C16H20N2O2Purezza:98.94%Colore e forma:SolidPeso molecolare:272.34Darapladib
CAS:Darapladib (SB-480848) is a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with an IC50 value of 0.25 nM.Cost-effective and quality-assured.Formula:C36H38F4N4O2SPurezza:99.82% - >99.99%Colore e forma:SolidPeso molecolare:666.77RHC 80267
CAS:RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)Formula:C20H34N4O4Purezza:99.54%Colore e forma:White SolidPeso molecolare:394.51GW4869
CAS:GW4869 (GW69A) is a selective and non-competitive inhibitor of neutral sphingomyelinase N-SMase (IC50=1 μM).Formula:C30H30Cl2N6O2Purezza:98.12% - 98.47%Colore e forma:SolidPeso molecolare:577.5RPI-1
CAS:<p>RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.</p>Formula:C17H15NO4Purezza:98.91% - ≥95%Colore e forma:SolidPeso molecolare:297.311-Linoleoyl Glycerol
CAS:1-Linoleoyl Glycerol (Monolinolein) is fatty acid glycerol that has been isolated from Saururus Chinensis roots.Formula:C21H38O4Purezza:98.95% - 99.15%Colore e forma:Less Oil Colourless OilPeso molecolare:354.52ONO-RS-082
CAS:ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.Formula:C21H22ClNO3Purezza:99.35%Colore e forma:SolidPeso molecolare:371.86AA26-9
CAS:AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.Formula:C7H10N4OPurezza:99.88%Colore e forma:SolidPeso molecolare:166.181-Naphthaleneacetic acid potassium salt
CAS:1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) is a synthetic phytogrowth hormone that promotes plant growth and a PLA2 inhibitor.Formula:C12H9O2·KPurezza:97.68%Colore e forma:Off-White To Beige PowderPeso molecolare:224.3Difluprednate
CAS:<p>Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.</p>Formula:C27H34F2O7Purezza:99.23% - 99.86%Colore e forma:SolidPeso molecolare:508.55Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurezza:98.02% - 99.83%Colore e forma:SolidPeso molecolare:360.43CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Formula:C26H28N4O2Purezza:98%Colore e forma:SolidPeso molecolare:428.53
