PKM
La Piruvato Chinasi M2 (PKM2) è una isoforma della piruvato chinasi che svolge un ruolo cruciale nella glicolisi, convertendo il fosfoenolpiruvato in piruvato. PKM2 è coinvolta nella regolazione della riprogrammazione metabolica nelle cellule tumorali, rendendola un potenziale bersaglio per la terapia del cancro. Gli inibitori di PKM2 possono alterare le vie metaboliche, ridurre la crescita tumorale e indurre la morte cellulare nelle cellule cancerose. Presso CymitQuimica, offriamo inibitori di PKM2 per supportare la tua ricerca nel metabolismo del cancro, in oncologia e nello sviluppo terapeutico.
Trovati 17 prodotti di "PKM"
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PKR-IN-2
CAS:PKR-IN-2 is a activator of pyruvate kinase (PKR).Formula:C24H28N4O4SPurezza:99.14%Colore e forma:SolidPeso molecolare:468.57Ref: TM-T12499
1mg81,00€5mg145,00€10mg207,00€25mg334,00€50mg467,00€100mg655,00€200mg883,00€1mL*10mM (DMSO)149,00€Dimethylaminomicheliolide HCl
CAS:Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvateFormula:C17H28ClNO3Purezza:99.91%Colore e forma:SoildPeso molecolare:329.86PKM2 inhibitor G
CAS:PKM2 inhibitor G is a inhibitor of pyruvate kinase.Formula:C16H15NO3SPurezza:99.89%Colore e forma:SoildPeso molecolare:301.36Ref: TM-T67900
1mg109,00€5mg243,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€1mL*10mM (DMSO)230,00€PKM2 activator 7
PKM2 activator 7 (Compd B4) is a PKM2 activator with an AC50 value of 0.144 μM. It functions by inhibiting the growth of T cells, thereby alleviating DSS-induced colitis in mice.Formula:C16H19F3O4Peso molecolare:332.12354PKM2-IN-10
PKM2-IN-10 is a PKM2 inhibitor. It effectively suppresses the proliferation of A549 and HCC1833 cell lines with IC50 values of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 demonstrates antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. It is applicable for research in lung cancer.Formula:C21H15F4N5Colore e forma:SolidPeso molecolare:413.12636PKCζ/ι pseudosubstrate inhibitor
CAS:PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction ofFormula:C76H128N30O16Colore e forma:SolidPeso molecolare:1718.02Mitapivat sulfate hydrate
CAS:Mitapivat sulfate hydrate (AG 348 sulfate hydrate) is a pyruvate kinase (PK) allosteric activator, used to study pyruvate kinase deficiency.Formula:C24H26N4O3S1H2SO43H2OPurezza:99.22%Colore e forma:SolidPeso molecolare:526.6DASA-58
CAS:DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Formula:C19H23N3O6S2Purezza:96.96% - 99.28%Colore e forma:SolidPeso molecolare:453.53Mitapivat
CAS:Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.Formula:C24H26N4O3SPurezza:99.47% - 99.83%Colore e forma:SolidPeso molecolare:450.55PKM2-IN-1
CAS:PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.Formula:C18H19NO2S2Purezza:99.49% - 99.68%Colore e forma:SolidPeso molecolare:345.48TEPP-46
CAS:TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. Cost-effective and quality-assured.Formula:C17H16N4O2S2Purezza:98.21% - 99.65%Colore e forma:SolidPeso molecolare:372.46Ref: TM-T7214
1mg48,00€5mg96,00€10mg144,00€25mg235,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)96,00€PKM2 activator 5
CAS:PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.Formula:C18H19FN2O6S2Purezza:98%Colore e forma:SolidPeso molecolare:442.48PKM2 activator 2
CAS:PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates
Formula:C20H18F2N2O4S2Purezza:99.92%Colore e forma:SolidPeso molecolare:452.49NPD10084
CAS:NPD10084 is an inhibitor of pyruvate kinase PKM2 that blocks non-glycolytic signaling in cancer cells by disrupting PKM2's interaction with β-catenin or STAT3, thus inhibiting downstream pathways. It demonstrates antiproliferative effects against colorectal cancer cells both in vitro and in vivo [1].Formula:C21H19N3O2Colore e forma:SolidPeso molecolare:345.39Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Formula:C24H27ClN4O3SColore e forma:SolidPeso molecolare:487.014PKM2-IN-9
CAS:PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Formula:C24H22N4O2Colore e forma:SolidPeso molecolare:398.457PKR Inhibitor, negative control
CAS:The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.Formula:C15H8Cl3NO2Peso molecolare:340.59
