LRRK2
Gli inibitori di LRRK2 sono composti che inibiscono l'attività della Leucine-Rich Repeat Kinase 2 (LRRK2), un enzima coinvolto in diversi processi cellulari, tra cui l'autofagia, il traffico vescicolare e l'infiammazione. Le mutazioni nel gene LRRK2 sono associate a un aumento del rischio di sviluppare la malattia di Parkinson, rendendo LRRK2 un bersaglio significativo per la ricerca sulle malattie neurodegenerative. Gli inibitori di LRRK2 sono cruciali per esplorare il ruolo di LRRK2 nel Parkinson e per sviluppare potenziali strategie terapeutiche. Presso CymitQuimica, offriamo una selezione di inibitori di LRRK2 per supportare la tua ricerca in neurodegenerazione, segnalazione chinasi e sviluppo terapeutico.
Trovati 43 prodotti per "LRRK2".
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MLi-2
CAS:MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.Formula:C21H25N5O2Purezza:98.96%Colore e forma:SolidPeso molecolare:379.46Ref: TM-T16115
1mg55,00€2mg84,00€5mg126,00€1mL*10mM (DMSO)135,00€10mg178,00€25mg409,00€50mg618,00€100mg880,00€BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Formula:C26H30N6O2Purezza:97.44% - 99.7%Colore e forma:SolidPeso molecolare:458.56FX 2149
CAS:FX 2149 is a GTP-binding inhibitor that potently inhibits LRRK2 GTP binding and kinase activity in vitro and attenuates the toxic effects of LRRK2 in Parkinson’s disease models.Formula:C15H17N3O3SPurezza:99.94%Peso molecolare:319.38XL01126
XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.Formula:C50H64ClFN10O6S2Colore e forma:SolidPeso molecolare:1019.69JH-XII-03-02
CAS:JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PDFormula:C43H51N9O10Purezza:98%Colore e forma:SolidPeso molecolare:853.92RN341
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM). It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.Colore e forma:Odour SolidRN277
RN277 is an inhibitor of LRRK2 type II kinase (LRRK2type II kinase). It serves as a cellular tool targeting the inactive state of LRRK2. In vitro, RN277 inhibits LRRK1 kinase activity and the kinase activity of LRRK2, with an IC50 of 70 nM. Additionally, it reduces Rab8a phosphorylation in a dose-dependent manner. RN277 is useful for Parkinson's disease research.Colore e forma:Odour SolidCC-3240
CAS:CC-3240 (compound 13), a molecular glue degrader of CaMKK2 based on CC-8977, has an IC50 of 9 nM [1].Formula:C52H64N6O7SColore e forma:SolidPeso molecolare:917.17Nictide
CAS:Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.Formula:C123H193N45O28Colore e forma:SolidPeso molecolare:2750.13CZC-54252 hydrochloride
CAS:CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Formula:C22H26Cl2N6O4SPurezza:98.21%Colore e forma:SolidPeso molecolare:541.45Ref: TM-T39202
5mg49,00€1mL*10mM (DMSO)60,00€10mg72,00€25mg128,00€50mg205,00€100mg301,00€200mg425,00€EB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Formula:C22H22N8OPurezza:99.53%Colore e forma:White SolidPeso molecolare:414.46Ref: TM-T39972
1mg66,00€2mg87,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg215,00€25mg388,00€50mg577,00€100mg820,00€200mg1.099,00€Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Colore e forma:Odour LiquidCZC-25146 hydrochloride
CAS:CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.Formula:C22H26ClFN6O4SPurezza:98.76%Colore e forma:White SolidPeso molecolare:525CZC-54252
CAS:CZC-54252 is a potent inhibitor of LRRK2.Formula:C22H25ClN6O4SPurezza:99.39%Colore e forma:SolidPeso molecolare:504.99GNE-7915
CAS:GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.Formula:C19H21F4N5O3Purezza:98% - ≥95%Colore e forma:SolidPeso molecolare:443.4Ref: TM-T1945
5mg44,00€1mL*10mM (DMSO)48,00€10mg58,00€25mg108,00€50mg177,00€100mg299,00€200mg389,00€500mg645,00€GNE0877
CAS:GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).Formula:C14H16F3N7Purezza:98.01% - 99.97%Colore e forma:White SolidPeso molecolare:339.32Ref: TM-T6031
1mg44,00€2mg57,00€1mL*10mM (DMSO)90,00€5mg113,00€10mg177,00€25mg356,00€50mg532,00€100mg760,00€500mg1.558,00€PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Formula:C14H16N6OPurezza:99.06%Colore e forma:SolidPeso molecolare:284.32GNE-9605
CAS:GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).Formula:C17H20ClF4N7OPurezza:98.55% - 98.75%Colore e forma:White SolidPeso molecolare:449.83HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formula:C17H20ClN5O3Purezza:99.59%Colore e forma:SolidPeso molecolare:377.83Ref: TM-T7196
2mg35,00€5mg55,00€1mL*10mM (DMSO)62,00€10mg89,00€25mg161,00€50mg250,00€100mg360,00€200mg512,00€LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Formula:C31H38N8O3Purezza:98% - 98.82%Colore e forma:SolidPeso molecolare:570.69JH-II-127
CAS:JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 nM (A2016T).Formula:C19H21ClN6O3Purezza:98.32%Colore e forma:White SolidPeso molecolare:416.86Ref: TM-T7155
2mg43,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg166,00€50mg259,00€100mg366,00€200mg520,00€PFE-360
CAS:PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).Formula:C16H16N6OPurezza:98.14% - 99.73%Colore e forma:SolidPeso molecolare:308.34Ref: TM-T16512
1mg71,00€5mg160,00€1mL*10mM (DMSO)170,00€10mg215,00€25mg371,00€50mg522,00€100mg745,00€IKK 16
CAS:IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Formula:C28H29N5OSPurezza:98.76% - 99.61%Colore e forma:SolidPeso molecolare:483.63Ref: TM-T6176
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg132,00€25mg233,00€50mg385,00€100mg550,00€200mg782,00€GSK2578215A
CAS:GSK2578215A is a potent and selective LRRK2 kinase inhibitor.Formula:C24H18FN3O2Purezza:99.57% - 99.99%Colore e forma:SolidPeso molecolare:399.42PF-06447475
CAS:PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Formula:C17H15N5OPurezza:98.61% - 99.62%Colore e forma:SolidPeso molecolare:305.33GNE-7915 tosylate
CAS:GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.Formula:C26H29F4N5O6SColore e forma:SolidPeso molecolare:615.6CZC-25146
CAS:CZC-25146, a stable LRRK2 inhibitor, IC50: 4.76 nM (wild-type), 6.87 nM (G2019S).Formula:C22H25FN6O4SPurezza:97.68%Colore e forma:SolidPeso molecolare:488.54LRRK2-IN-10
CAS:LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2Formula:C20H15N5OPurezza:98%Colore e forma:SolidPeso molecolare:341.37PF-06371900
CAS:PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).Formula:C17H16N6O2SColore e forma:SolidPeso molecolare:368.41PF-06455943
CAS:PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.Formula:C17H14FN5OColore e forma:SolidPeso molecolare:323.32LRRK2-IN-7
CAS:LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.Formula:C24H26N6OPurezza:99.89%Colore e forma:SolidPeso molecolare:414.5LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Formula:C24H26F2N4O2SColore e forma:SolidPeso molecolare:472.55LRRK2-IN-2
CAS:LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.Formula:C23H23Cl2F3N6O2Colore e forma:SolidPeso molecolare:543.37LRRK2-IN-3
CAS:LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.Formula:C25H29ClF2N6O2Colore e forma:SolidPeso molecolare:518.99LRRK2-IN-20
CAS:LRRK2-IN-20 (EX. 4.64) is a selective inhibitor of LRRK2 with a potency of pIC50 at 0.7921 nM. This compound is applicable in research studies focused on Parkinson's Disease (PD).Formula:C24H32ClN7OColore e forma:SolidPeso molecolare:470.01SRI-31255
CAS:SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.Formula:C15H14N4Colore e forma:SolidPeso molecolare:250.30LRRK2-IN-12
CAS:LRRK2-IN-12 (compound 1) is a potent inhibitor of LRRK2 (G20195) with an IC 50 of 0.45 nM, LRRK2 WT with an IC 50 of 1.1 nM, and LRRK2 WT ADP-Glo with an IC 50 of 0.46 nM. This compound is utilized in research related to Alzheimer's Disease [1].Formula:C18H17ClN8O2Colore e forma:SolidPeso molecolare:412.83LRRK2-IN-13
CAS:LRRK2-IN-13 (Compound 13), with an IC50 value of 0.57 nM, serves as an inhibitor of LRRK2 and exhibits properties that allow it to penetrate the brain [1].Formula:C19H19ClN8O2Colore e forma:SolidPeso molecolare:426.86LRRK2-IN-14
CAS:LRRK2-IN-14 (Compound 8), an orally active inhibitor of LRRK2, exhibits an IC 50 of 6.3 nM against LRRK2(G2019S) cell activity and demonstrates inhibitory effects on hERG with an IC 50 of 22 μM. Additionally, LRRK2-IN-14 is permeable to the blood-brain barrier [1].Formula:C17H18F3N5O2Colore e forma:SolidPeso molecolare:381.35(R,R)-LRRK2-IN-7
CAS:(R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.Formula:C24H26N6OColore e forma:SolidPeso molecolare:414.50LRRK2-IN-16
CAS:LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.Formula:C18H19N5OSColore e forma:SolidPeso molecolare:353.441LRRK2-IN-4
CAS:LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.Formula:C25H29ClF2N6O2Colore e forma:SolidPeso molecolare:518.99LRRK2-IN-6
LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).Formula:C23H24F2N4O2SColore e forma:SolidPeso molecolare:458.52
