Beta amiloide
Gli inibitori del beta-amiloide sono composti che mirano specificamente a inibire la formazione o l'aggregazione dei peptidi beta-amiloidi, coinvolti in modo critico nella patogenesi della malattia di Alzheimer. L'accumulo di placche di beta-amiloide nel cervello è uno dei tratti patologici distintivi della malattia, contribuendo alla disfunzione neuronale e al declino cognitivo. Inibendo l'aggregazione del beta-amiloide, questi inibitori sono studiati come potenziali agenti terapeutici per rallentare o prevenire la progressione della malattia di Alzheimer. Presso CymitQuimica, offriamo una gamma di inibitori del beta-amiloide di alta qualità per supportare la tua ricerca nella neurodegenerazione, nell'aggregazione proteica e nella terapia dell'Alzheimer.
Trovati 222 prodotti di "Beta amiloide"
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(Rac)-Z-Phe-Phe-FMK
CAS:(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .Formula:C27H27FN2O4Purezza:98.27%Colore e forma:SolidPeso molecolare:462.51TH-237A
CAS:TH-237A is a novel neuroprotective agent exhibiting favorable permeation across the blood-brain barrier.Formula:C18H17F2NO3Purezza:98%Colore e forma:SolidPeso molecolare:333.335Cu(II)GTSM
CAS:Cu(II)GTSM is a cell permeable copper complex inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau.Formula:C6H10CuN6S2Purezza:99.21%Colore e forma:SolidPeso molecolare:293.86AZD4694
CAS:Flutafuranol (AZD4694/NAV4694) binds beta-amyloid, potential PET tracer for Alzheimer's. Non-F18 version supplied.Formula:C14H11FN2O2Colore e forma:SolidPeso molecolare:258.25Frentizole
CAS:Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interactionFormula:C15H13N3O2SPurezza:99.82%Colore e forma:SolidPeso molecolare:299.35PE859
CAS:PE859 is a potent inhibitor of both tau and Aβ aggregation.Formula:C28H24N4O2Purezza:98.8% - 99.09%Colore e forma:SolidPeso molecolare:448.52MK-0752
CAS:<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Formula:C21H21ClF2O4SPurezza:98% - 99.55%Colore e forma:SolidPeso molecolare:442.9Semax acetate(80714-61-0 free base)
CAS:Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.Formula:C39H55N9O12SPurezza:99.46%Colore e forma:SolidPeso molecolare:873.98RO4929097
CAS:<p>RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).</p>Formula:C22H20F5N3O3Purezza:98.5% - 99.51%Colore e forma:SolidPeso molecolare:469.4Anle138b
CAS:Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's diseaseFormula:C16H11BrN2O2Purezza:98.88% - 99.82%Colore e forma:SolidPeso molecolare:343.17Benzenesulfonamide
CAS:Benzenesulfonamide (Benzosulfonamide) ia an inhibitor of carbonic anhydrases.Formula:C6H7NO2SPurezza:99.42% - 99.99%Colore e forma:White Crystalline PowderPeso molecolare:157.19Cromoglicic acid
CAS:<p>Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.</p>Formula:C23H16O11Purezza:99.55% - >99.99%Colore e forma:Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Peso molecolare:468.37PBD-150
CAS:PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)Formula:C15H20N4O2SPurezza:99.68%Colore e forma:SolidPeso molecolare:320.41Dihydroergocristine mesylate
CAS:DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.Formula:C36H45N5O8SPurezza:98.9% - 99.79%Colore e forma:SolidPeso molecolare:707.84Azeliragon HCl
CAS:Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.Formula:C32H40Cl3N3O2Colore e forma:SolidPeso molecolare:605.04Semagacestat
CAS:Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).Formula:C19H27N3O4Purezza:97.1% - 99.9%Colore e forma:SolidPeso molecolare:361.44JLK6
CAS:JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signallingFormula:C10H8ClNO3Purezza:96.50%Colore e forma:SolidPeso molecolare:225.631,1'-Methylenedi-2-naphthol
CAS:1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).Formula:C21H16O2Purezza:98.91%Colore e forma:Light Pink To Light Brown Crystalline PowderPeso molecolare:300.35Azeliragon
CAS:Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-Formula:C32H38ClN3O2Purezza:96.7% - 98.33%Colore e forma:SolidPeso molecolare:532.12Edonerpic maleate
CAS:Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).Formula:C20H25NO6SPurezza:98.24%Colore e forma:SolidPeso molecolare:407.48EUK-134
CAS:EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formula:C18H18ClMnN2O4Purezza:98.39%Colore e forma:SolidPeso molecolare:416.74Miridesap
CAS:<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Formula:C16H24N2O6Purezza:≥95%Colore e forma:SolidPeso molecolare:340.37ARN2966
CAS:ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.Formula:C12H12N2OPurezza:99.52% - 99.86%Colore e forma:SolidPeso molecolare:200.24CRANAD 2
CAS:CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.Formula:C23H25BF2N2O2Purezza:99.44%Colore e forma:Dark Blue To Black PowderPeso molecolare:410.27Simufilam hydrochloride
CAS:Simufilam is an oral, low-toxicity FLNA activator for Alzheimer's research, fixing FLNA structure and reducing pathology.Formula:C15H22ClN3OColore e forma:SolidPeso molecolare:295.81PiB
CAS:<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Formula:C14H12N2OSPurezza:97.02%Colore e forma:SolidPeso molecolare:256.32Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Formula:C8H10NO6PPurezza:97.52%Colore e forma:SolidPeso molecolare:247.14TAE-1
CAS:<p>TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.</p>Formula:C39H51I3N6O9Purezza:94.58%Colore e forma:SolidPeso molecolare:1128.57FPS-ZM1
CAS:FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.Formula:C20H22ClNOPurezza:99.32% - 99.52%Colore e forma:SolidPeso molecolare:327.85Aftin-4
CAS:Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.Formula:C20H28N6OPurezza:98.51%Colore e forma:SolidPeso molecolare:368.48γ-Secretase modulator 13
CAS:γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.Formula:C22H23FN6SPurezza:99.79%Colore e forma:SolidPeso molecolare:422.52Solanezumab
CAS:<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Purezza:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:144.1 (kDa)4-Hydroxyindole
CAS:4-Hydroxyindole: aromatic, antioxidant, used in cancer treatment and preventing neurodegenerative diseases.Formula:C8H7NOPurezza:97.05% - 98.13%Colore e forma:Off-White Cyrstalline SolidPeso molecolare:133.15Dezamizumab
CAS:Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.Purezza:95% - 98.2% (SDS-PAGE); 98.7% (SEC-HPLC)Colore e forma:LiquidBapineuzumab
CAS:Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).Purezza:95%Colore e forma:LiquidRemternetug
CAS:Remternetug (LY3372993) is a humanised monoclonal antibody targeting N3pG-Aβ, recognising pyroglutamated Aβ within amyloid plaques, Alzheimer's disease.Purezza:95% - 97.6% (SDS-PAGE); 98.7% (SEC-HPLC)Colore e forma:LiquidHomotaurine-d6
CAS:Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.Formula:C3D6H3NO3SColore e forma:SolidPeso molecolare:145.21Nicardipine pyridine metabolite II
CAS:Nicardipine pyridine metabolite II is a biaoctive chemical.Formula:C26H27N3O6Colore e forma:SolidPeso molecolare:477.514-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).Formula:C14H11BrN2SPurezza:98%Colore e forma:SolidPeso molecolare:319.224-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.Formula:C13H9BrN2SPurezza:98%Colore e forma:SolidPeso molecolare:305.19Aftin-5
CAS:Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.Formula:C19H26N6OColore e forma:SolidPeso molecolare:354.45Eprodisate
CAS:Eprodisate disrupts protein-glycosaminoglycan binding, halting amyloid fibril formation, potentially delaying AA amyloidosis progression.Formula:C3H8O6S2Colore e forma:SolidPeso molecolare:204.22BACE1/2-IN-1
CAS:BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.Formula:C21H31N5OSColore e forma:SolidPeso molecolare:401.57BuChE-IN-2
CAS:BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.Formula:C28H20F4N6O3Colore e forma:SolidPeso molecolare:564.49TML-6
CAS:TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.Formula:C30H37NO7Purezza:99.71%Colore e forma:SolidPeso molecolare:523.62Caprospinol
CAS:Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.Formula:C33H52O4Purezza:98%Colore e forma:SolidPeso molecolare:512.76AZ4800
CAS:AZD4800 is a gamma secretase modulators.Formula:C24H29N5O3Colore e forma:SolidPeso molecolare:435.52SV5
CAS:SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.Formula:C21H30N2O4S2Colore e forma:SolidPeso molecolare:438.6Antioxidant agent-2
CAS:Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.Formula:C23H26N2O7Colore e forma:SolidPeso molecolare:442.46RS-0466
CAS:RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.Formula:C17H17N5O2Purezza:98%Colore e forma:SolidPeso molecolare:323.35SEN-1269
CAS:SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.Formula:C18H18N4O2Purezza:98%Colore e forma:SolidPeso molecolare:322.36AY1511
CAS:AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].Formula:C17H14O6Colore e forma:SolidPeso molecolare:314.29Glutaminyl Cyclase Inhibitor 5
Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) ofFormula:C22H30N6OColore e forma:SolidPeso molecolare:394.51KMS88009
CAS:KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.Formula:C19H19NO2Colore e forma:SolidPeso molecolare:293.36γ-Secretase modulator 12
CAS:γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.Formula:C25H23N3O2Colore e forma:SolidPeso molecolare:397.47RU-505
CAS:RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.Formula:C28H32FN5OPurezza:98%Colore e forma:SolidPeso molecolare:473.58Astrophloxine
CAS:Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue andFormula:C27H33IN2Purezza:99.89%Colore e forma:SolidPeso molecolare:512.47Aβ Fibrillization modulator 1
CAS:Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.Formula:C17H12N4O3SSeColore e forma:SolidPeso molecolare:431.33Neuroinflammatory-IN-2
CAS:Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.Formula:C25H27FN2O3Colore e forma:SolidPeso molecolare:422.49q-FTAA
CAS:q-FTAA targets Aβ1-42 fibrils (330-630 nM) and ADPBC (300-500 nM), useful in Alzheimer's disease research.Formula:C21H14O6S4Colore e forma:SolidPeso molecolare:490.59LC kinetic stabilizer-2
CAS:LC Kinetic Stabilizer-2 is a powerful stabilizer for amyloidogenic immunoglobulin light chains (LC), demonstrating significant efficacy with an EC50 of 24 nM.Formula:C28H31N3O3Colore e forma:SolidPeso molecolare:457.56ELND006
CAS:ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.Formula:C20H14F5N3O2SColore e forma:SolidPeso molecolare:455.4TC-E 5006
CAS:γ-secretase modulatorFormula:C29H29F4NO2Purezza:98%Colore e forma:SolidPeso molecolare:499.54OAB-14
CAS:OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.Formula:C32H46N4O2Colore e forma:SolidPeso molecolare:518.73BTA-1
CAS:BTA-1 is an uncharged derivative of thioflavin-T that has high affinity for Aβ fibrils and shows very good brain entry and clearance [1].Formula:C14H12N2SColore e forma:SolidPeso molecolare:240.32CGP52411
CAS:CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).Formula:C20H15N3O2Purezza:99.78%Colore e forma:SolidPeso molecolare:329.35YIAD-0205
CAS:YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familialFormula:C26H16Br2ClN3Colore e forma:SolidPeso molecolare:565.69K 01-162
CAS:K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.Formula:C15H14BrNColore e forma:SolidPeso molecolare:288.18Chrysamine G
CAS:Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.Formula:C26H16N4Na2O6Colore e forma:SolidPeso molecolare:526.416Glutaminyl Cyclase Inhibitor 2
CAS:Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).Formula:C19H20FN3Purezza:98%Colore e forma:SolidPeso molecolare:309.38JNJ-40418677
CAS:JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.Formula:C26H22F6O2Purezza:98%Colore e forma:SolidPeso molecolare:480.44BChE-IN-8
CAS:BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.Formula:C18H12BrN7O2Colore e forma:SolidPeso molecolare:438.24THK-523
CAS:THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.Formula:C17H15FN2OColore e forma:SolidPeso molecolare:282.31MAO-B-IN-9
CAS:<p>MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.</p>Formula:C18H24N2O2Purezza:99.93%Colore e forma:SolidPeso molecolare:300.4Buntanetap
CAS:Buntanetap ((+)-Phenserine) is an inhibitor of TINAPs used in the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular diseaseFormula:C20H23N3O2Purezza:98.2%Colore e forma:SolidPeso molecolare:337.42Aleplasinin
CAS:Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolyticFormula:C28H27NO3Purezza:99.21%Colore e forma:SolidPeso molecolare:425.52MK-3328
CAS:<p>MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.</p>Formula:C14H9FN4OPurezza:99.70% - >99.99%Colore e forma:SolidPeso molecolare:268.25DSS30
CAS:<p>DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.</p>Formula:C16H14ClNO3S2Purezza:99.19% - 99.4%Colore e forma:SolidPeso molecolare:367.87PPI-1019
CAS:PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).Formula:C36H54N6O5Purezza:95.16% - 98.16%Colore e forma:SolidPeso molecolare:650.85BI-1408
CAS:BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).Formula:C22H23FN6Purezza:99.63%Colore e forma:SolidPeso molecolare:390.46Aβ-IN-1
CAS:Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).Formula:C35H49NPurezza:99.1%Colore e forma:SoildPeso molecolare:483.77amyloid P-IN-1
CAS:amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, andFormula:C30H44N2O14Purezza:99.76%Colore e forma:SolidPeso molecolare:656.68Ezeprogind disulfate
CAS:Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.Formula:C25H48N6O8S2Purezza:99.72%Colore e forma:SolidPeso molecolare:624.81Fenlean
CAS:"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."Formula:C26H27NO6Purezza:98.99%Colore e forma:SolidPeso molecolare:449.5Glutaminyl Cyclase Inhibitor 1
CAS:Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.Formula:C21H24FN3O2Purezza:99.81%Colore e forma:SolidPeso molecolare:369.43QR-0217
CAS:QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.Formula:C19H13NO3Colore e forma:SolidPeso molecolare:303.31BMS 433796
CAS:<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Formula:C21H20F2N4O4Purezza:99.17%Colore e forma:SolidPeso molecolare:430.4QM-FN-SO3
CAS:QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].Formula:C29H25N4NaO3S2Colore e forma:SolidPeso molecolare:564.65NNC 26-9100
CAS:Somatostatin sst4 receptor agonistFormula:C22H25BrCl2N6SPurezza:98%Colore e forma:SolidPeso molecolare:556.35Anti-amyloid agent-1
CAS:Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].Formula:C21H17F3N2O3Colore e forma:SolidPeso molecolare:402.37ELND007
CAS:<p>ELND007 is a Gamma secretase inhibitor.</p>Formula:C19H14F4N4O2SColore e forma:SolidPeso molecolare:438.4TRV-1387
CAS:TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].Formula:C23H25F3N4O2Colore e forma:SolidPeso molecolare:446.47PQM130
CAS:PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.Formula:C23H27NO4Purezza:98.73%Colore e forma:SolidPeso molecolare:381.46rTRD01
CAS:rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269.Formula:C18H21FN4O2Colore e forma:SolidPeso molecolare:344.38RAGE/SERT-IN-1
CAS:RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM andFormula:C38H41ClN4OSColore e forma:SolidPeso molecolare:637.28Aβ/tau aggregation-IN-3
CAS:Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functionalFormula:C23H22N4O3Colore e forma:SolidPeso molecolare:402.45γ-Secretase-IN-1
CAS:γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.Formula:C27H24F2N4O3Purezza:99.56%Colore e forma:SolidPeso molecolare:490.5MDR-1339
CAS:MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.Formula:C20H22O4Purezza:98.57%Colore e forma:SolidPeso molecolare:326.39γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Colore e forma:SolidAmyloid-β-IN-3
CAS:<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formula:C22H21F2N3O2Colore e forma:SolidPeso molecolare:397.42
