Beta amiloide
Gli inibitori del beta-amiloide sono composti che mirano specificamente a inibire la formazione o l'aggregazione dei peptidi beta-amiloidi, coinvolti in modo critico nella patogenesi della malattia di Alzheimer. L'accumulo di placche di beta-amiloide nel cervello è uno dei tratti patologici distintivi della malattia, contribuendo alla disfunzione neuronale e al declino cognitivo. Inibendo l'aggregazione del beta-amiloide, questi inibitori sono studiati come potenziali agenti terapeutici per rallentare o prevenire la progressione della malattia di Alzheimer. Presso CymitQuimica, offriamo una gamma di inibitori del beta-amiloide di alta qualità per supportare la tua ricerca nella neurodegenerazione, nell'aggregazione proteica e nella terapia dell'Alzheimer.
Trovati 223 prodotti di "Beta amiloide"
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γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Colore e forma:SolidIXA62
CAS:IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.Formula:C24H23N3O3Colore e forma:SolidPeso molecolare:401.458Aβ aggregation-IN-1
CAS:Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.Formula:C9H8BF3O2Colore e forma:SolidPeso molecolare:215.965QP5020
CAS:QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.Formula:C20H19FN6Peso molecolare:362.40Anti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.Formula:C35H49NO4Colore e forma:SolidPeso molecolare:547.77MAO-B-IN-10
MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.Formula:C23H26N2O4Colore e forma:SolidPeso molecolare:394.46BF-168
CAS:BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).Formula:C18H17FN2O2Colore e forma:SolidPeso molecolare:312.34Aβ42 agonist-1
CAS:<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Formula:C15H11NO2Purezza:99.77%Colore e forma:SolidPeso molecolare:237.25Aβ-IN-2
Aβ-IN-2 is a peptide inhibitor of Aβ1-42.Formula:C37H51NOColore e forma:SolidPeso molecolare:525.81MAO-B-IN-45
CAS:MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.Formula:C17H14ClNO3Colore e forma:SolidPeso molecolare:315.75Thiazolo[5,4-c]pyridin-4(5H)-one
CAS:Thiazolo[5,4-c]pyridin-4(5H)-one is a compound used for diagnostic imaging of TDP-43, in PET imaging of neurodegenerative diseases ALS、AD、FTD、LATE.Formula:C22H22FN5O2SPurezza:98.75%Colore e forma:SolidPeso molecolare:439.51Glutaminyl Cyclase Inhibitor 3
CAS:Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.Formula:C24H32N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:468.61Amilo-5MER
CAS:Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.Formula:C23H40N6O9SColore e forma:SolidPeso molecolare:576.664cSPM
cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.Formula:C27H57N7Colore e forma:SolidPeso molecolare:479.79γ-secretase modulator 6
CAS:<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Formula:C25H26N6O2Colore e forma:SolidPeso molecolare:442.513Buntanetap L-Tartrate
CAS:Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].Formula:C24H29N3O8Colore e forma:SolidPeso molecolare:487.50(9R)-RO7185876
CAS:(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.Formula:C25H28F3N7Colore e forma:SolidPeso molecolare:483.532Amyloid-β-IN-2
CAS:Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.Formula:C22H21F2N3O2Colore e forma:SolidPeso molecolare:397.42Antioxidant agent-8
Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.Formula:C13H12O5Colore e forma:SolidPeso molecolare:248.232002-G12
CAS:2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.Formula:C20H16N6Colore e forma:SolidPeso molecolare:340.381BMS 299897
CAS:<p>BMS 299897, a sulfonamide γ-secretase inhibitor, inhibits Aβ production with an IC50 of 7 nM in HEK293 cells overexpressing APP.</p>Formula:C24H21ClF3NO4SPurezza:99.82%Colore e forma:SolidPeso molecolare:511.94Xanthocillin X permethyl ether
CAS:Xanthocillin X permethyl ether, a natural product extracted from fungal sources, exhibits Aβ-42 lowering activity.Formula:C20H16N2O2Purezza:98%Colore e forma:SolidPeso molecolare:316.35BF 227
CAS:BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].Formula:C16H16FN3O2SColore e forma:SolidPeso molecolare:333.38
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