Beta amiloide
Gli inibitori del beta-amiloide sono composti che mirano specificamente a inibire la formazione o l'aggregazione dei peptidi beta-amiloidi, coinvolti in modo critico nella patogenesi della malattia di Alzheimer. L'accumulo di placche di beta-amiloide nel cervello è uno dei tratti patologici distintivi della malattia, contribuendo alla disfunzione neuronale e al declino cognitivo. Inibendo l'aggregazione del beta-amiloide, questi inibitori sono studiati come potenziali agenti terapeutici per rallentare o prevenire la progressione della malattia di Alzheimer. Presso CymitQuimica, offriamo una gamma di inibitori del beta-amiloide di alta qualità per supportare la tua ricerca nella neurodegenerazione, nell'aggregazione proteica e nella terapia dell'Alzheimer.
Trovati 223 prodotti di "Beta amiloide"
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RS-0466
CAS:RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.Formula:C17H17N5O2Purezza:98%Colore e forma:SolidPeso molecolare:323.35THK-523
CAS:THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.Formula:C17H15FN2OColore e forma:SolidPeso molecolare:282.31ELND006
CAS:ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.Formula:C20H14F5N3O2SColore e forma:SolidPeso molecolare:455.4Glutaminyl Cyclase Inhibitor 2
CAS:Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).Formula:C19H20FN3Purezza:98%Colore e forma:SolidPeso molecolare:309.38AY1511
CAS:AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].Formula:C17H14O6Colore e forma:SolidPeso molecolare:314.29KMS88009
CAS:KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.Formula:C19H19NO2Colore e forma:SolidPeso molecolare:293.36TC-E 5006
CAS:γ-secretase modulatorFormula:C29H29F4NO2Purezza:98%Colore e forma:SolidPeso molecolare:499.54BChE-IN-8
CAS:BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.Formula:C18H12BrN7O2Colore e forma:SolidPeso molecolare:438.24Chrysamine G
CAS:Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.Formula:C26H16N4Na2O6Colore e forma:SolidPeso molecolare:526.416OAB-14
CAS:OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.Formula:C32H46N4O2Colore e forma:SolidPeso molecolare:518.73Astrophloxine
CAS:Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue andFormula:C27H33IN2Purezza:99.89%Colore e forma:SolidPeso molecolare:512.47BuChE-IN-2
CAS:BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.Formula:C28H20F4N6O3Colore e forma:SolidPeso molecolare:564.49TML-6
CAS:TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.Formula:C30H37NO7Purezza:99.71%Colore e forma:SolidPeso molecolare:523.62q-FTAA
CAS:q-FTAA targets Aβ1-42 fibrils (330-630 nM) and ADPBC (300-500 nM), useful in Alzheimer's disease research.Formula:C21H14O6S4Colore e forma:SolidPeso molecolare:490.59SEN-1269
CAS:SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.Formula:C18H18N4O2Purezza:98%Colore e forma:SolidPeso molecolare:322.36YIAD-0205
CAS:YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familialFormula:C26H16Br2ClN3Colore e forma:SolidPeso molecolare:565.69K 01-162
CAS:K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.Formula:C15H14BrNColore e forma:SolidPeso molecolare:288.18LC kinetic stabilizer-2
CAS:LC Kinetic Stabilizer-2 is a powerful stabilizer for amyloidogenic immunoglobulin light chains (LC), demonstrating significant efficacy with an EC50 of 24 nM.Formula:C28H31N3O3Colore e forma:SolidPeso molecolare:457.56RU-505
CAS:RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.Formula:C28H32FN5OPurezza:98%Colore e forma:SolidPeso molecolare:473.58CGP52411
CAS:CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).Formula:C20H15N3O2Purezza:99.78%Colore e forma:SolidPeso molecolare:329.35Aβ Fibrillization modulator 1
CAS:Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.Formula:C17H12N4O3SSeColore e forma:SolidPeso molecolare:431.33SV5
CAS:SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.Formula:C21H30N2O4S2Colore e forma:SolidPeso molecolare:438.6Antioxidant agent-2
CAS:Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.Formula:C23H26N2O7Colore e forma:SolidPeso molecolare:442.46BACE1/2-IN-1
CAS:BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.Formula:C21H31N5OSColore e forma:SolidPeso molecolare:401.57Fenlean
CAS:"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."Formula:C26H27NO6Purezza:98.99%Colore e forma:SolidPeso molecolare:449.5PPI-1019
CAS:PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).Formula:C36H54N6O5Purezza:95.16% - 98.16%Colore e forma:SolidPeso molecolare:650.85MAO-B-IN-9
CAS:<p>MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.</p>Formula:C18H24N2O2Purezza:99.93%Colore e forma:SolidPeso molecolare:300.4Ezeprogind disulfate
CAS:Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.Formula:C25H48N6O8S2Purezza:99.72%Colore e forma:SolidPeso molecolare:624.81BI-1408
CAS:BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).Formula:C22H23FN6Purezza:99.63%Colore e forma:SolidPeso molecolare:390.46MK-3328
CAS:<p>MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.</p>Formula:C14H9FN4OPurezza:99.70% - >99.99%Colore e forma:SolidPeso molecolare:268.25Aleplasinin
CAS:Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolyticFormula:C28H27NO3Purezza:99.21%Colore e forma:SolidPeso molecolare:425.52DSS30
CAS:<p>DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.</p>Formula:C16H14ClNO3S2Purezza:99.19% - 99.4%Colore e forma:SolidPeso molecolare:367.87Glutaminyl Cyclase Inhibitor 1
CAS:Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.Formula:C21H24FN3O2Purezza:99.81%Colore e forma:SolidPeso molecolare:369.43amyloid P-IN-1
CAS:amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, andFormula:C30H44N2O14Purezza:99.76%Colore e forma:SolidPeso molecolare:656.68Aβ-IN-1
CAS:Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).Formula:C35H49NPurezza:99.1%Colore e forma:SoildPeso molecolare:483.77Buntanetap
CAS:Buntanetap ((+)-Phenserine) is an inhibitor of TINAPs used in the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular diseaseFormula:C20H23N3O2Purezza:98.2%Colore e forma:SolidPeso molecolare:337.42PQM130
CAS:PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.Formula:C23H27NO4Purezza:98.73%Colore e forma:SolidPeso molecolare:381.46QR-0217
CAS:QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.Formula:C19H13NO3Colore e forma:SolidPeso molecolare:303.31Aβ/tau aggregation-IN-3
CAS:Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functionalFormula:C23H22N4O3Colore e forma:SolidPeso molecolare:402.45Anti-amyloid agent-1
CAS:Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].Formula:C21H17F3N2O3Colore e forma:SolidPeso molecolare:402.37TRV-1387
CAS:TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].Formula:C23H25F3N4O2Colore e forma:SolidPeso molecolare:446.47rTRD01
CAS:rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269.Formula:C18H21FN4O2Colore e forma:SolidPeso molecolare:344.38RAGE/SERT-IN-1
CAS:RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM andFormula:C38H41ClN4OSColore e forma:SolidPeso molecolare:637.28BMS 433796
CAS:<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Formula:C21H20F2N4O4Purezza:99.17%Colore e forma:SolidPeso molecolare:430.4NNC 26-9100
CAS:Somatostatin sst4 receptor agonistFormula:C22H25BrCl2N6SPurezza:98%Colore e forma:SolidPeso molecolare:556.35QM-FN-SO3
CAS:QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].Formula:C29H25N4NaO3S2Colore e forma:SolidPeso molecolare:564.65ELND007
CAS:<p>ELND007 is a Gamma secretase inhibitor.</p>Formula:C19H14F4N4O2SColore e forma:SolidPeso molecolare:438.4γ-Secretase-IN-1
CAS:γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.Formula:C27H24F2N4O3Purezza:99.56%Colore e forma:SolidPeso molecolare:490.5MDR-1339
CAS:MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.Formula:C20H22O4Purezza:98.57%Colore e forma:SolidPeso molecolare:326.39Amyloid-β-IN-3
CAS:<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formula:C22H21F2N3O2Colore e forma:SolidPeso molecolare:397.42
