COX
Gli inibitori della cicloossigenasi (COX) sono composti che bloccano l'attività degli enzimi COX, coinvolti nella produzione di prostaglandine, mediatori chiave dell'infiammazione e del dolore. In neuroscienze, gli inibitori della COX sono studiati per il loro potenziale nel ridurre la neuroinfiammazione, implicata in varie malattie neurodegenerative come l'Alzheimer, il Parkinson e la sclerosi multipla. Inibendo la COX, questi composti possono aiutare a mitigare i processi infiammatori nel cervello e a proteggere dai danni neuronali. Presso CymitQuimica, offriamo una gamma di inibitori della COX per supportare la tua ricerca sulla neuroinfiammazione, la gestione del dolore e le malattie neurodegenerative.
Trovati 561 prodotti di "COX"
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COX-2/sEH-IN-1
CAS:<p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>Formula:C23H18F3N5O3SColore e forma:SolidPeso molecolare:501.48COX-1/2-IN-1
CAS:<p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>Formula:C15H10BrClN2OColore e forma:SolidPeso molecolare:349.61COX-1/2-IN-3
CAS:<p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>Formula:C14H8N2O8Colore e forma:SolidPeso molecolare:332.22COX-2-IN-23
CAS:<p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>Formula:C24H25N5O3S2Colore e forma:SolidPeso molecolare:495.62COX-2-IN-24
CAS:<p>COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.</p>Formula:C24H24BrN5O3S2Colore e forma:SolidPeso molecolare:574.51COX-2-IN-19
CAS:<p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>Formula:C18H18N4O2SColore e forma:SolidPeso molecolare:354.43COX-2/5-LOX-IN-2
CAS:<p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>Formula:C18H13N3O4S2Colore e forma:SolidPeso molecolare:399.44Piroxicam cinnamate
CAS:<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Formula:C24H19N3O5SColore e forma:SolidPeso molecolare:461.49APHS
CAS:<p>APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.</p>Formula:C15H18O2SColore e forma:SolidPeso molecolare:262.37COX-2-IN-21
CAS:<p>COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.</p>Formula:C21H22N6O4Colore e forma:SolidPeso molecolare:422.44SC58451
CAS:<p>SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.</p>Formula:C20H19FO2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:342.43Enflicoxib
CAS:<p>Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.</p>Formula:C16H12F5N3O2SPurezza:99.88%Colore e forma:SolidPeso molecolare:405.34Prostaglandin G/H synthase 1 inhibitor
CAS:<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Formula:C13H11ClN2OPurezza:99.76%Colore e forma:SolidPeso molecolare:246.69Feprazone
CAS:<p>Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.</p>Formula:C20H20N2O2Purezza:99.6% - 99.89%Colore e forma:SolidPeso molecolare:320.39COX-2-IN-20
CAS:<p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>Formula:C11H9ClFN3O2Colore e forma:SolidPeso molecolare:269.66SC-75416
CAS:<p>SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.</p>Formula:C15H14ClF3O3Purezza:98.67% - 98.67%Colore e forma:SolidPeso molecolare:334.72Eltenac
CAS:<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Formula:C12H9Cl2NO2SPurezza:98.53%Colore e forma:SolidPeso molecolare:302.18BN-82451 2HCl
CAS:<p>BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.</p>Formula:C18H28Cl2N2OSPurezza:99.84% - >99.99%Colore e forma:SolidPeso molecolare:391.4ER-34122
CAS:<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Formula:C27H26ClN3O5Purezza:>99.99%Colore e forma:SolidPeso molecolare:507.96ABT-963
CAS:<p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>Formula:C22H22F2N2O5SPurezza:98% - 99.85%Colore e forma:SolidPeso molecolare:464.48Indazole-Cl
CAS:<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Formula:C13H9ClN2O2Purezza:99.02% - 99.86%Colore e forma:SolidPeso molecolare:260.68Sudoxicam
CAS:<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Formula:C13H11N3O4S2Purezza:99.93%Colore e forma:SolidPeso molecolare:337.37Apyramide
CAS:<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Formula:C27H23ClN2O5Purezza:99.93%Colore e forma:SolidPeso molecolare:490.93LM-1685
CAS:<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Formula:C18H16ClNO4SPurezza:98.16%Colore e forma:SolidPeso molecolare:377.84L 651896
CAS:<p>L 651896 is an inhibitor of 5-lipoxygenase.</p>Formula:C18H18O3Purezza:96.06% - 99.85%Colore e forma:SolidPeso molecolare:282.33Biofor 389
CAS:<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Formula:C20H29NO3Purezza:98.84% - 99.97%Colore e forma:SolidPeso molecolare:331.45Amtolmetin guacil
CAS:<p>Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。</p>Formula:C24H24N2O5Purezza:99.85%Colore e forma:White Needle-Shaped CrystalPeso molecolare:420.46(-)-Bornyl ferulate
CAS:<p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>Formula:C20H26O4Purezza:98%Colore e forma:SolidPeso molecolare:330.42Cimicoxib
CAS:<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Formula:C16H13ClFN3O3SPurezza:98.22%Colore e forma:SolidPeso molecolare:381.81Prostaglandin E2 Ethanolamide
CAS:<p>Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].</p>Formula:C22H37NO5Colore e forma:SolidPeso molecolare:395.54Antioxidant agent-15
CAS:<p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>Formula:C19H14O2Purezza:98%Colore e forma:SolidPeso molecolare:274.31BW 755C
CAS:<p>BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.</p>Formula:C10H10F3N3Purezza:96.52%Colore e forma:SolidPeso molecolare:229.2Thioflosulide
CAS:<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Formula:C16H13F2NO3S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:369.41Benoxaprofen
CAS:<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Formula:C16H12ClNO3Purezza:98.87%Colore e forma:SolidPeso molecolare:301.72Thromboxane B3
CAS:<p>Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.</p>Formula:C20H32O6Colore e forma:SolidPeso molecolare:368.5COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formula:C15H10ClIN2OColore e forma:SolidPeso molecolare:396.61COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Formula:C19H18N2O5SColore e forma:SolidPeso molecolare:386.42COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Formula:C25H21N3O3SColore e forma:SolidPeso molecolare:443.52COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formula:C31H32FN5O2SColore e forma:SolidPeso molecolare:557.68Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formula:C18H15N5O2SColore e forma:SolidPeso molecolare:365.41(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formula:C16H14O3Colore e forma:SolidPeso molecolare:254.28STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Formula:C28H25ClN6O5Colore e forma:SolidPeso molecolare:560.988COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Formula:C17H19NO3Colore e forma:SolidPeso molecolare:285.34COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formula:C22H23FN2O6S2Colore e forma:SolidPeso molecolare:494.56NLRP3-IN-69
CAS:<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Formula:C25H24O7Colore e forma:SolidPeso molecolare:436.454COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Formula:C16H17N5O2Colore e forma:SolidPeso molecolare:311.34COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Formula:C19H19N3O4S2Colore e forma:SolidPeso molecolare:417.5COX-2-IN-6
CAS:<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Formula:C20H27NO6SPurezza:99.29% - 99.69%Colore e forma:SoildPeso molecolare:409.5COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Formula:C15H13N3O2S2Colore e forma:SolidPeso molecolare:331.41Neral
CAS:<p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>Formula:C10H16OColore e forma:SolidPeso molecolare:152.23COX-2-IN-51
CAS:<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Formula:C23H18F4O3SColore e forma:SolidPeso molecolare:450.446COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Formula:C15H15NO3Colore e forma:SolidPeso molecolare:257.28Soquelitinib
CAS:<p>Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.</p>Formula:C25H30N4O4S2Purezza:99.54%Colore e forma:SolidPeso molecolare:514.66Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Formula:C17H13BrN4O3S2Colore e forma:SolidPeso molecolare:465.34Ambuic acid
CAS:<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formula:C19H26O6Colore e forma:SolidPeso molecolare:350.41COX-2-IN-47
CAS:<p>COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.</p>Formula:C18H18N2O4Colore e forma:SolidPeso molecolare:326.35COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Formula:C25H23N5O4S2Colore e forma:SolidPeso molecolare:521.61Sabialimon P
CAS:<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Formula:C31H50O4Colore e forma:SolidPeso molecolare:486.73COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Formula:C19H14ClN5S2Colore e forma:SolidPeso molecolare:411.93XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Formula:C24H20N4O2SColore e forma:SolidPeso molecolare:428.51Racemic Naproxen
CAS:<p>Racemic Naproxen is a biochemical substance.</p>Formula:C14H14O3Purezza:98%Colore e forma:Crystals From Acetone-Hexane White SolidPeso molecolare:230.26
