COX
Gli inibitori della cicloossigenasi (COX) sono composti che bloccano l'attività degli enzimi COX, coinvolti nella produzione di prostaglandine, mediatori chiave dell'infiammazione e del dolore. In neuroscienze, gli inibitori della COX sono studiati per il loro potenziale nel ridurre la neuroinfiammazione, implicata in varie malattie neurodegenerative come l'Alzheimer, il Parkinson e la sclerosi multipla. Inibendo la COX, questi composti possono aiutare a mitigare i processi infiammatori nel cervello e a proteggere dai danni neuronali. Presso CymitQuimica, offriamo una gamma di inibitori della COX per supportare la tua ricerca sulla neuroinfiammazione, la gestione del dolore e le malattie neurodegenerative.
Trovati 562 prodotti di "COX"
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7,3',4'-Tri-O-methylluteolin
CAS:<p>7,3',4'-Tri-O-methylluteolin is anti-inflammatory, antibacterial, antifungal, and has moderate antitrypanosomal effects (MIC 19.0 ug/ml).</p>Formula:C18H16O6Purezza:98.66% - 99.79%Colore e forma:SolidPeso molecolare:328.32NS-398
CAS:<p>NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a COX-2 inhibitor wih anti-inflammatory activity.</p>Formula:C13H18N2O5SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:314.36Tolmetin
CAS:<p>Tolmetin (Tolectin) NSAID; acts as a cyclooxygenase inhibitor; classified as an anti-inflammatory.</p>Formula:C15H15NO3Purezza:99.74% - >99.99%Colore e forma:Off-White Crystalline PowerPeso molecolare:257.28α-Spinasterol
CAS:<p>α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects.</p>Formula:C29H48OPurezza:97.03% - 99.58%Colore e forma:SolidPeso molecolare:412.69Cis-5-Dodecenoic Acid
CAS:<p>Cis-5-Dodecenoic Acid is a monounsaturated fatty acid that has a C12 chain as a backbone and a cis double bond at the C5 position.</p>Formula:C12H22O2Purezza:98% - 99.37%Colore e forma:SolidPeso molecolare:198.3Avicularin
CAS:<p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>Formula:C20H18O11Purezza:97.02% - 99.94%Colore e forma:White PowderPeso molecolare:434.35Hamaudol
CAS:<p>Hamaudol, from Saposhnikovia divaricata, has pain-relief and anti-inflammatory effects, inhibits COX-1/COX-2 (0.30/0.57 mM).</p>Formula:C15H16O5Purezza:99.62%Colore e forma:SolidPeso molecolare:276.28Adelmidrol
CAS:<p>Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.</p>Formula:C13H26N2O4Purezza:99.35% - 99.73%Colore e forma:SolidPeso molecolare:274.36(-)-Catechin gallate
CAS:<p>(-)-Catechin gallate inhibits 6PGD, IDH, Beta-secretase, and fights chloroquine-sensitive/resistant Plasmodium falciparum.</p>Formula:C22H18O10Purezza:97.74% - >99.99%Colore e forma:SolidPeso molecolare:442.37Lumiracoxib
CAS:<p>Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.</p>Formula:C15H13ClFNO2Purezza:96.64% - 99.77%Colore e forma:Pale Yellow SolidPeso molecolare:293.72FK 3311
CAS:<p>FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (</p>Formula:C15H13F2NO4SPurezza:97.98%Colore e forma:SolidPeso molecolare:341.33Propyphenazone
CAS:<p>Propyphenazone: an anti-inflammatory, analgesic, antipyretic pyrazolone; prodrug; COX-2 inhibitor.</p>Formula:C14H18N2OPurezza:99.64%Colore e forma:SolidPeso molecolare:230.31Teriflunomide impurity 3
CAS:<p>Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor(IC50 of 30 μM).</p>Formula:C14H11F3N2OPurezza:99.62%Colore e forma:SolidPeso molecolare:280.25Otenaproxesul
CAS:<p>Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.</p>Formula:C21H19NO3SPurezza:98.76% - 99.13%Colore e forma:SolidPeso molecolare:365.45Fenoprofen Calcium
CAS:<p>Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.</p>Formula:C30H26CaO6Purezza:99.24% - 99.66%Colore e forma:SolidPeso molecolare:522.6Licofelone
CAS:<p>Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.</p>Formula:C23H22ClNO2Purezza:99.25%Colore e forma:Yellowish SolidPeso molecolare:379.88Chebulagic acid
CAS:<p>Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.</p>Formula:C41H30O27Purezza:97.82% - 99.8%Colore e forma:SolidPeso molecolare:954.66(-)-Epicatechin gallate
CAS:<p>(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.</p>Formula:C22H18O10Purezza:99.16% - 99.93%Colore e forma:SolidPeso molecolare:442.37Flurbiprofen Axetil
CAS:<p>Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.</p>Formula:C19H19FO4Purezza:97.58% - 98%Colore e forma:SolidPeso molecolare:330.35Phenidone
CAS:<p>Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.</p>Formula:C9H10N2OPurezza:97.24%Colore e forma:White Solid Solid CrystallinePeso molecolare:162.19ETHYL CAFFEATE
CAS:<p>Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.</p>Formula:C11H12O4Purezza:97.79%Colore e forma:SolidPeso molecolare:208.21Indomethacin farnesil
CAS:<p>Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.</p>Formula:C34H40ClNO4Purezza:97.29%Colore e forma:SolidPeso molecolare:562.14N-trans-Feruloyltyramine
CAS:<p>NTF is hepatoprotective, antioxidant, inhibits COX, prevents platelet aggregation, and reduces melanin by downregulating tyrosinase.</p>Formula:C18H19NO4Purezza:99.56% - >99.99%Colore e forma:SolidPeso molecolare:313.35Ginsenoside Rg5
CAS:<p>Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.</p>Formula:C42H70O12Purezza:98% - 99.65%Colore e forma:SolidPeso molecolare:767Tolmetin sodium
CAS:<p>Tolmetin sodium is an NSAID, orally active COX inhibitor with IC50 of 0.35 μM (COX-1) and 0.82 μM (COX-2).</p>Formula:C15H14NNaO3Colore e forma:SolidPeso molecolare:279.271Bromfenac
CAS:<p>Bromfenac, a potent COX inhibitor, targets ocular inflammation with IC50s of 5.56 nM for COX-1 and 7.45 nM for COX-2.</p>Formula:C15H12BrNO3Colore e forma:SolidPeso molecolare:334.16Fenoprofen
CAS:Fenoprofen (LILLY-5385) is a non-steroidal anti-inflammatory compound and a modifier enhancer of the melanocortin receptor, increasing ERK1/2 activation.Formula:C15H14O3Purezza:98.4%Colore e forma:SolidPeso molecolare:242.27NF-κB/MAPK-IN-1
CAS:<p>NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).</p>Formula:C27H27NO7Purezza:97.03%Colore e forma:SolidPeso molecolare:477.51(S)-(+)-Ibuprofen
CAS:<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Formula:C13H18O2Purezza:99.51% - 99.86%Colore e forma:Colourless Crystalline SolidPeso molecolare:206.28Bromfenac sodium hydrate
CAS:Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.Formula:C15H12BrNO3H2O·NaPurezza:91.85% - 99.65%Colore e forma:SolidPeso molecolare:383.17Meloxicam
CAS:<p>Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.</p>Formula:C14H13N3O4S2Purezza:97.09% - 99.60%Colore e forma:Light Yellow SolidPeso molecolare:351.40Oxyphenbutazone
CAS:<p>Oxyphenbutazone: Non-selective COX inhibitor, anti-inflammatory, kills dormant Mycobacterium tuberculosis.</p>Formula:C19H20N2O3Purezza:99.41% - 99.88%Colore e forma:White To Yellowish White Crystalline Powder SolidPeso molecolare:324.37Tenidap
CAS:<p>Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.</p>Formula:C14H9ClN2O3SPurezza:98.56% - 99.42%Colore e forma:SolidPeso molecolare:320.75Paradol
CAS:<p>Paradol, a spicy compound in ginger, offers anti-cancer, anti-inflammatory, antioxidant, and neuroprotective benefits.</p>Formula:C17H26O3Purezza:98.4% - 98.98%Colore e forma:SolidPeso molecolare:278.39Fontolizumab
CAS:<p>Fontolizumab (HuZAF) is a humanised IgG1 monoclonal anti-IFN-gamma (IFN-γ) antibody for the study of Crohn's disease.</p>Purezza:95%Colore e forma:LiquidPeso molecolare:150 (kDa)Anti-IL-12 p70 Antibody (20C2)
Anti-IL-12 p70 Antibody (20C2), an IgG1 monoclonal, suppresses interferon-gamma, IL-12-mediated inflammation, paired with a Rat IgG1 kappa control.Purezza:95%Cadonilimab
CAS:<p>Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion.</p>Purezza:95% - 95%Colore e forma:LiquidAspirin DL-lysine
CAS:<p>Aspirin DL-lysine: a water-soluble, injectable NSAID that may also hinder cancer growth.</p>Formula:C15H22N2O6Colore e forma:Crystalline SolidPeso molecolare:326.35Imidazole Salicylate
CAS:<p>Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.</p>Formula:C10H10N2O3Purezza:98%Colore e forma:SolidPeso molecolare:206.2Indometacin Farnesil
CAS:Formula:C34H40ClNO4Purezza:>98.0%(HPLC)Colore e forma:Light yellow to Yellow to Orange clear liquidPeso molecolare:562.15Ketorolac-d5
CAS:<p>Ketorolac-d5 is a deuterated compound of ketorolac for isotope tracing. Ketorolac is a non-steroidal anti-inflammatory agent and inhibitor of COX-1 and COX-2.</p>Formula:C15H8D5NO3Purezza:98.99%Colore e forma:SolidPeso molecolare:260.3Nepafenac-d5
CAS:<p>Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .</p>Formula:C15H14N2O2Purezza:98%Colore e forma:SolidPeso molecolare:259.31Amfenac
CAS:<p>Amfenac promotes apoptosis in ARPE-19 cell culture.</p>Formula:C15H13NO3Colore e forma:SolidPeso molecolare:255.27AHR-10037
CAS:<p>AHR-10037, a NSAID, offers pain relief, fever reduction, safety, and low stomach risk, acting as a prodrug for COX inhibitors.</p>Formula:C15H13ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:288.73Pelubiprofen
CAS:<p>Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.</p>Formula:C16H18O3Purezza:99.69%Colore e forma:SolidPeso molecolare:258.31COX-2-IN-21
CAS:<p>COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.</p>Formula:C21H22N6O4Colore e forma:SolidPeso molecolare:422.44SC57666
CAS:<p>SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.</p>Formula:C18H17FO2SPurezza:98.83%Colore e forma:SolidPeso molecolare:316.39ASP-6537
CAS:<p>ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.</p>Formula:C17H17N3O3Purezza:98%Colore e forma:SolidPeso molecolare:311.34L 748780
CAS:<p>L 748780 is a selective inducible COX-2 inhibitor.</p>Formula:C19H14Cl3NO4Purezza:98%Colore e forma:SolidPeso molecolare:426.68Heterophdoid A
CAS:<p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>Formula:C26H42O10Colore e forma:SolidPeso molecolare:514.61LY 150310
CAS:<p>LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.</p>Formula:C13H14N2Colore e forma:SolidPeso molecolare:198.26ZXX2-77
CAS:<p>ZXX2-77 is a cyclooxygenase-1 inhibitor.</p>Formula:C13H13ClN2O2SPurezza:98%Colore e forma:SolidPeso molecolare:296.77LY 25648
CAS:<p>LY 25648 is an antagonist of leukotriene B4.</p>Formula:C19H27NO2SColore e forma:SolidPeso molecolare:333.49Lobeglitazone Sulfate
CAS:<p>Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.</p>Formula:C24H26N4O9S2Purezza:98.69%Colore e forma:SolidPeso molecolare:578.61Naproxen glucuronide
CAS:<p>Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.</p>Formula:C20H22O9Colore e forma:SolidPeso molecolare:406.38Pifoxime
CAS:<p>Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.</p>Formula:C15H20N2O3Colore e forma:SolidPeso molecolare:276.33AHR-6293
CAS:<p>AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.</p>Formula:C15H12ClNO3Colore e forma:SolidPeso molecolare:289.71Carpro-AM1
CAS:<p>Carpro-AM1, dual FAAH/COX inhibitor, IC50: 94 nM.</p>Formula:C21H18ClN3OColore e forma:SolidPeso molecolare:363.84Nitroflurbiprofen
CAS:<p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>Formula:C19H20FNO5Purezza:99.88%Colore e forma:SolidPeso molecolare:361.36COX-2-IN-2
CAS:<p>COX-2-IN-2 selectively inhibits COX2 (IC50: 0.24 μM); COX-2-IN-1 offers anti-inflammatory and pain relief.</p>Formula:C17H12FN3O2SPurezza:97.62%Colore e forma:SolidPeso molecolare:341.36COX-2-IN-11
CAS:<p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>Formula:C12H12OS3Colore e forma:SolidPeso molecolare:268.42MK-0703
CAS:<p>MK-0703 is a selective cyclooxygenase-2 inhibitor.</p>Formula:C17H22O5SPurezza:98%Colore e forma:SolidPeso molecolare:338.42COX/5-LO-IN-1
CAS:<p>COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.</p>Formula:C16H15FN2O2SPurezza:98%Colore e forma:SolidPeso molecolare:318.37COX-2/15-LOX-IN-1
CAS:<p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>Formula:C21H21N7S3Colore e forma:SolidPeso molecolare:467.63COX-2-IN-16
CAS:<p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>Formula:C19H12BrN3O2Colore e forma:SolidPeso molecolare:394.22FR-188582
CAS:<p>FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).</p>Formula:C16H13ClN2O2SPurezza:98%Colore e forma:SolidPeso molecolare:332.8Flosulide
CAS:<p>Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.</p>Formula:C16H13F2NO4SPurezza:98%Colore e forma:SolidPeso molecolare:353.34SC58451
CAS:<p>SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.</p>Formula:C20H19FO2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:342.43COX-2-IN-20
CAS:<p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>Formula:C11H9ClFN3O2Colore e forma:SolidPeso molecolare:269.66NCX 466
CAS:<p>cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor</p>Formula:C20H24N2O9Purezza:98%Colore e forma:SolidPeso molecolare:436.41PD 127443
CAS:<p>PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.</p>Formula:C20H28N2OColore e forma:SolidPeso molecolare:312.45Etoricoxib HCl
CAS:<p>Etoricoxib HCl is a synthetic NSAID that inhibits COX-2, blocking prostaglandin production.</p>Formula:C18H16Cl2N2O2SColore e forma:SolidPeso molecolare:395.30Thiazolinobutazone
CAS:<p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>Formula:C22H26N4O2SColore e forma:SolidPeso molecolare:410.53COX-1/2-IN-3
CAS:<p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>Formula:C14H8N2O8Colore e forma:SolidPeso molecolare:332.22PC407-ws
CAS:<p>PC407-ws is a water-soluble novel COX-2 inhibitor.</p>Formula:C24H18F3N3Na2O5SPurezza:98%Colore e forma:SolidPeso molecolare:563.46Isonixin
CAS:<p>Isonixin is used for the treatment of inflammation and pain associated with musculoskeletal and joint disorders.</p>Formula:C14H14N2O2Purezza:98%Colore e forma:SolidPeso molecolare:242.27Tenosal
CAS:<p>Tenosal obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid, and with analgesic and antipyretic properties, anti-inflammatory.</p>Formula:C12H8O4SPurezza:98%Colore e forma:SolidPeso molecolare:248.25Loxoprofenol-SRS tromethamine
CAS:<p>Loxoprofenol-SRS tromethamine (HR1405-01), a metabolite of Loxoprofen, is a safe IV NSAID with strong anti-inflammatory and pain relief properties.</p>Formula:C19H31NO6Colore e forma:SolidPeso molecolare:369.45K-80001
CAS:<p>K-80001 is a selective RXRα ligand and a COX-1/2 inhibitor, exhibiting IC50 values of 82.9μM for RXRα, 3.4μM for COX-1, and 1.2μM for COX-2, respectively [1].</p>Formula:C20H17FO2Colore e forma:SolidPeso molecolare:308.35COX-2-IN-28
CAS:<p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>Formula:C30H27N7S3Colore e forma:SolidPeso molecolare:581.78GW-406381
CAS:<p>GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.</p>Formula:C21H19N3O3SPurezza:99.54%Colore e forma:SolidPeso molecolare:393.46(-)-Ibuprofenamide
CAS:<p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>Formula:C13H19NOPurezza:98%Colore e forma:SolidPeso molecolare:205.3Naproxcinod
CAS:<p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>Formula:C18H21NO6Colore e forma:SolidPeso molecolare:347.36COX-2-IN-24
CAS:<p>COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.</p>Formula:C24H24BrN5O3S2Colore e forma:SolidPeso molecolare:574.51COX-2-IN-19
CAS:<p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>Formula:C18H18N4O2SColore e forma:SolidPeso molecolare:354.43COX-2/5-LOX-IN-2
CAS:<p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>Formula:C18H13N3O4S2Colore e forma:SolidPeso molecolare:399.44Piroxicam cinnamate
CAS:<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Formula:C24H19N3O5SColore e forma:SolidPeso molecolare:461.49COX-2/5-LOX-IN-1
CAS:<p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 & 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>Formula:C14H10ClN3O4S2Colore e forma:SolidPeso molecolare:383.83LY 178002
CAS:<p>LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.</p>Formula:C18H25NO2SPurezza:98%Colore e forma:SolidPeso molecolare:319.46COX-1/2-IN-1
CAS:<p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>Formula:C15H10BrClN2OColore e forma:SolidPeso molecolare:349.61COX-2-IN-23
CAS:<p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>Formula:C24H25N5O3S2Colore e forma:SolidPeso molecolare:495.62COX-2-IN-26
CAS:<p>COX-2-IN-26: Oral, selective COX-2 inhibitor, low IC50s; anti-inflammatory with GI safety.</p>Formula:C23H21N7OS3Colore e forma:SolidPeso molecolare:507.65COX-2/sEH-IN-1
CAS:<p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>Formula:C23H18F3N5O3SColore e forma:SolidPeso molecolare:501.48APHS
CAS:<p>APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.</p>Formula:C15H18O2SColore e forma:SolidPeso molecolare:262.37Anti-inflammatory agent 56
CAS:<p>Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by</p>Formula:C21H15F3N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:476.43Anti-inflammatory agent 8
CAS:<p>Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.</p>Formula:C18H15N5OS2Colore e forma:SolidPeso molecolare:381.47COX/5-LOX-IN-1
CAS:<p>Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.</p>Formula:C18H30O3Colore e forma:SolidPeso molecolare:294.43COX-2/5-LOX-IN-3
CAS:<p>COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.</p>Formula:C17H16ClN3O2SColore e forma:SolidPeso molecolare:361.85Feprazone
CAS:<p>Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.</p>Formula:C20H20N2O2Purezza:99.6% - 99.89%Colore e forma:SolidPeso molecolare:320.39Naproxen etemesil
CAS:<p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>Formula:C17H20O5SPurezza:98%Colore e forma:SolidPeso molecolare:336.4ATB-337
CAS:<p>S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.</p>Formula:C23H15Cl2NO2S3Colore e forma:SolidPeso molecolare:504.47Tilmacoxib
CAS:<p>Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).</p>Formula:C16H19FN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:338.4COX-2-IN-1
CAS:<p>COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).</p>Formula:C18H14ClF3N4O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:442.84Apricoxib
CAS:<p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>Formula:C19H20N2O3SColore e forma:SolidPeso molecolare:356.44COX-2-IN-17
CAS:<p>COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.</p>Formula:C20H23ClN6O2Colore e forma:SolidPeso molecolare:414.89Insulin levels modulator
CAS:<p>Insulin level regulators can be used to treat diabetes.</p>Formula:C21H23N7OSPurezza:98%Colore e forma:SolidPeso molecolare:421.52ADU-S100
CAS:<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Formula:C20H24N10O10P2S2Purezza:99.83%Colore e forma:SolidPeso molecolare:690.54COX-2-IN-32
CAS:<p>COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.</p>Formula:C25H24O6Purezza:98%Colore e forma:SolidPeso molecolare:420.45Enflicoxib
CAS:<p>Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.</p>Formula:C16H12F5N3O2SPurezza:99.88%Colore e forma:SolidPeso molecolare:405.34Safrole oxide
CAS:<p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>Formula:C10H10O3Purezza:100%Colore e forma:SolidPeso molecolare:178.18COX-2-IN-14
CAS:<p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>Formula:C18H18N4O6Colore e forma:SolidPeso molecolare:386.364Prostaglandin G/H synthase 1 inhibitor
CAS:<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Formula:C13H11ClN2OPurezza:99.76%Colore e forma:SolidPeso molecolare:246.69Eicosatetraynoic acid
CAS:<p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>Formula:C20H24O2Purezza:98%Colore e forma:SolidPeso molecolare:296.4Timegadine
CAS:<p>Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM</p>Formula:C20H23N5SPurezza:98%Colore e forma:SolidPeso molecolare:365.5AL-8417
CAS:<p>AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.</p>Formula:C29H34O5Purezza:98%Colore e forma:SolidPeso molecolare:462.58COX-2-IN-18
CAS:<p>COX-2-IN-18 is a potent COX-2 inhibitor similar to Celecoxib, showing promise in cancer research. IC50=0.775μM.</p>Formula:C18H19N3O3S2Colore e forma:SolidPeso molecolare:389.49Eltenac
CAS:<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Formula:C12H9Cl2NO2SPurezza:98.53%Colore e forma:SolidPeso molecolare:302.18SC-75416
CAS:<p>SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.</p>Formula:C15H14ClF3O3Purezza:98.67% - 98.67%Colore e forma:SolidPeso molecolare:334.72BN-82451 2HCl
CAS:<p>BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.</p>Formula:C18H28Cl2N2OSPurezza:99.84% - >99.99%Colore e forma:SolidPeso molecolare:391.4Apyramide
CAS:<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Formula:C27H23ClN2O5Purezza:99.93%Colore e forma:SolidPeso molecolare:490.93ABT-963
CAS:<p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>Formula:C22H22F2N2O5SPurezza:98% - 99.85%Colore e forma:SolidPeso molecolare:464.48Biofor 389
CAS:<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Formula:C20H29NO3Purezza:98.84% - 99.97%Colore e forma:SolidPeso molecolare:331.45L 651896
CAS:<p>L 651896 is an inhibitor of 5-lipoxygenase.</p>Formula:C18H18O3Purezza:96.06% - 99.85%Colore e forma:SolidPeso molecolare:282.33ER-34122
CAS:<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Formula:C27H26ClN3O5Purezza:>99.99%Colore e forma:SolidPeso molecolare:507.96LM-1685
CAS:<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Formula:C18H16ClNO4SPurezza:98.16%Colore e forma:SolidPeso molecolare:377.84Sudoxicam
CAS:<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Formula:C13H11N3O4S2Purezza:99.93%Colore e forma:SolidPeso molecolare:337.37Indazole-Cl
CAS:<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Formula:C13H9ClN2O2Purezza:99.02% - 99.86%Colore e forma:SolidPeso molecolare:260.68Antioxidant agent-15
CAS:<p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>Formula:C19H14O2Purezza:98%Colore e forma:SolidPeso molecolare:274.31Cimicoxib
CAS:<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Formula:C16H13ClFN3O3SPurezza:98.22%Colore e forma:SolidPeso molecolare:381.81(-)-Bornyl ferulate
CAS:<p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>Formula:C20H26O4Purezza:98%Colore e forma:SolidPeso molecolare:330.42Thioflosulide
CAS:<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Formula:C16H13F2NO3S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:369.41Thromboxane B3
CAS:<p>Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.</p>Formula:C20H32O6Colore e forma:SolidPeso molecolare:368.5BW 755C
CAS:<p>BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.</p>Formula:C10H10F3N3Purezza:96.52%Colore e forma:SolidPeso molecolare:229.2Amtolmetin guacil
CAS:<p>Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。</p>Formula:C24H24N2O5Purezza:99.85%Colore e forma:White Needle-Shaped CrystalPeso molecolare:420.46Benoxaprofen
CAS:<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Formula:C16H12ClNO3Purezza:98.87%Colore e forma:SolidPeso molecolare:301.72Prostaglandin E2 Ethanolamide
CAS:<p>Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].</p>Formula:C22H37NO5Colore e forma:SolidPeso molecolare:395.54COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Formula:C15H15NO3Colore e forma:SolidPeso molecolare:257.28COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Formula:C25H23N5O4S2Colore e forma:SolidPeso molecolare:521.61Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Formula:C17H13BrN4O3S2Colore e forma:SolidPeso molecolare:465.34XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Formula:C24H20N4O2SColore e forma:SolidPeso molecolare:428.51COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Formula:C19H19N3O4S2Colore e forma:SolidPeso molecolare:417.5COX-2-IN-47
CAS:<p>COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.</p>Formula:C18H18N2O4Colore e forma:SolidPeso molecolare:326.35COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Formula:C15H13N3O2S2Colore e forma:SolidPeso molecolare:331.41COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formula:C31H32FN5O2SColore e forma:SolidPeso molecolare:557.68COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Formula:C17H19NO3Colore e forma:SolidPeso molecolare:285.34COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Formula:C16H17N5O2Colore e forma:SolidPeso molecolare:311.34Ambuic acid
CAS:<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formula:C19H26O6Colore e forma:SolidPeso molecolare:350.41Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formula:C18H15N5O2SColore e forma:SolidPeso molecolare:365.41COX-2-IN-51
CAS:<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Formula:C23H18F4O3SColore e forma:SolidPeso molecolare:450.446NLRP3-IN-69
CAS:<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Formula:C25H24O7Colore e forma:SolidPeso molecolare:436.454COX-2-IN-6
CAS:<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Formula:C20H27NO6SPurezza:99.29% - 99.69%Colore e forma:SoildPeso molecolare:409.5Sabialimon P
CAS:<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Formula:C31H50O4Colore e forma:SolidPeso molecolare:486.73(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formula:C16H14O3Colore e forma:SolidPeso molecolare:254.28COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Formula:C19H14ClN5S2Colore e forma:SolidPeso molecolare:411.93COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Formula:C25H21N3O3SColore e forma:SolidPeso molecolare:443.52Neral
CAS:<p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>Formula:C10H16OColore e forma:SolidPeso molecolare:152.23COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Formula:C19H18N2O5SColore e forma:SolidPeso molecolare:386.42COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formula:C15H10ClIN2OColore e forma:SolidPeso molecolare:396.61Soquelitinib
CAS:<p>Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.</p>Formula:C25H30N4O4S2Purezza:99.54%Colore e forma:SolidPeso molecolare:514.66STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Formula:C28H25ClN6O5Colore e forma:SolidPeso molecolare:560.988COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formula:C22H23FN2O6S2Colore e forma:SolidPeso molecolare:494.56Racemic Naproxen
CAS:<p>Racemic Naproxen is a biochemical substance.</p>Formula:C14H14O3Purezza:98%Colore e forma:Crystals From Acetone-Hexane White SolidPeso molecolare:230.26
