COX
Gli inibitori della cicloossigenasi (COX) sono composti che bloccano l'attività degli enzimi COX, coinvolti nella produzione di prostaglandine, mediatori chiave dell'infiammazione e del dolore. In neuroscienze, gli inibitori della COX sono studiati per il loro potenziale nel ridurre la neuroinfiammazione, implicata in varie malattie neurodegenerative come l'Alzheimer, il Parkinson e la sclerosi multipla. Inibendo la COX, questi composti possono aiutare a mitigare i processi infiammatori nel cervello e a proteggere dai danni neuronali. Presso CymitQuimica, offriamo una gamma di inibitori della COX per supportare la tua ricerca sulla neuroinfiammazione, la gestione del dolore e le malattie neurodegenerative.
Trovati 562 prodotti di "COX"
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Safrole oxide
CAS:<p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>Formula:C10H10O3Purezza:100%Colore e forma:SolidPeso molecolare:178.18(-)-Ibuprofenamide
CAS:<p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>Formula:C13H19NOPurezza:98%Colore e forma:SolidPeso molecolare:205.3Piroxicam cinnamate
CAS:<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Formula:C24H19N3O5SColore e forma:SolidPeso molecolare:461.49GW-406381
CAS:<p>GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.</p>Formula:C21H19N3O3SPurezza:99.54%Colore e forma:SolidPeso molecolare:393.46COX-2/5-LOX-IN-2
CAS:<p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>Formula:C18H13N3O4S2Colore e forma:SolidPeso molecolare:399.44COX-2-IN-19
CAS:<p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>Formula:C18H18N4O2SColore e forma:SolidPeso molecolare:354.43Timegadine
CAS:<p>Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM</p>Formula:C20H23N5SPurezza:98%Colore e forma:SolidPeso molecolare:365.5ADU-S100
CAS:<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Formula:C20H24N10O10P2S2Purezza:99.83%Colore e forma:SolidPeso molecolare:690.54COX-2/5-LOX-IN-1
CAS:<p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 & 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>Formula:C14H10ClN3O4S2Colore e forma:SolidPeso molecolare:383.83Heterophdoid A
CAS:<p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>Formula:C26H42O10Colore e forma:SolidPeso molecolare:514.61Naproxcinod
CAS:<p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>Formula:C18H21NO6Colore e forma:SolidPeso molecolare:347.36Nitroflurbiprofen
CAS:<p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>Formula:C19H20FNO5Purezza:99.88%Colore e forma:SolidPeso molecolare:361.36COX-2-IN-28
CAS:<p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>Formula:C30H27N7S3Colore e forma:SolidPeso molecolare:581.78COX-2-IN-11
CAS:<p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>Formula:C12H12OS3Colore e forma:SolidPeso molecolare:268.42Naproxen etemesil
CAS:<p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>Formula:C17H20O5SPurezza:98%Colore e forma:SolidPeso molecolare:336.4Apyramide
CAS:<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Formula:C27H23ClN2O5Purezza:99.93%Colore e forma:SolidPeso molecolare:490.93ABT-963
CAS:<p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>Formula:C22H22F2N2O5SPurezza:98% - 99.85%Colore e forma:SolidPeso molecolare:464.48ER-34122
CAS:<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Formula:C27H26ClN3O5Purezza:>99.99%Colore e forma:SolidPeso molecolare:507.96Eltenac
CAS:<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Formula:C12H9Cl2NO2SPurezza:98.53%Colore e forma:SolidPeso molecolare:302.18Sudoxicam
CAS:<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Formula:C13H11N3O4S2Purezza:99.93%Colore e forma:SolidPeso molecolare:337.37LM-1685
CAS:<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Formula:C18H16ClNO4SPurezza:98.16%Colore e forma:SolidPeso molecolare:377.84SC-75416
CAS:<p>SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.</p>Formula:C15H14ClF3O3Purezza:98.67% - 98.67%Colore e forma:SolidPeso molecolare:334.72BN-82451 2HCl
CAS:<p>BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.</p>Formula:C18H28Cl2N2OSPurezza:99.84% - >99.99%Colore e forma:SolidPeso molecolare:391.4Indazole-Cl
CAS:<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Formula:C13H9ClN2O2Purezza:99.02% - 99.86%Colore e forma:SolidPeso molecolare:260.68Biofor 389
CAS:<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Formula:C20H29NO3Purezza:98.84% - 99.97%Colore e forma:SolidPeso molecolare:331.45L 651896
CAS:<p>L 651896 is an inhibitor of 5-lipoxygenase.</p>Formula:C18H18O3Purezza:96.06% - 99.85%Colore e forma:SolidPeso molecolare:282.33Prostaglandin E2 Ethanolamide
CAS:<p>Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].</p>Formula:C22H37NO5Colore e forma:SolidPeso molecolare:395.54Benoxaprofen
CAS:<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Formula:C16H12ClNO3Purezza:98.87%Colore e forma:SolidPeso molecolare:301.72BW 755C
CAS:<p>BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.</p>Formula:C10H10F3N3Purezza:96.52%Colore e forma:SolidPeso molecolare:229.2Antioxidant agent-15
CAS:<p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>Formula:C19H14O2Purezza:98%Colore e forma:SolidPeso molecolare:274.31Thioflosulide
CAS:<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Formula:C16H13F2NO3S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:369.41Thromboxane B3
CAS:<p>Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.</p>Formula:C20H32O6Colore e forma:SolidPeso molecolare:368.5Amtolmetin guacil
CAS:<p>Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。</p>Formula:C24H24N2O5Purezza:99.85%Colore e forma:White Needle-Shaped CrystalPeso molecolare:420.46(-)-Bornyl ferulate
CAS:<p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>Formula:C20H26O4Purezza:98%Colore e forma:SolidPeso molecolare:330.42Cimicoxib
CAS:<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Formula:C16H13ClFN3O3SPurezza:98.22%Colore e forma:SolidPeso molecolare:381.81COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formula:C31H32FN5O2SColore e forma:SolidPeso molecolare:557.68COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Formula:C17H19NO3Colore e forma:SolidPeso molecolare:285.34COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Formula:C19H18N2O5SColore e forma:SolidPeso molecolare:386.42COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Formula:C19H19N3O4S2Colore e forma:SolidPeso molecolare:417.5Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formula:C18H15N5O2SColore e forma:SolidPeso molecolare:365.41Soquelitinib
CAS:<p>Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.</p>Formula:C25H30N4O4S2Purezza:99.54%Colore e forma:SolidPeso molecolare:514.66NLRP3-IN-69
CAS:<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Formula:C25H24O7Colore e forma:SolidPeso molecolare:436.454Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Formula:C17H13BrN4O3S2Colore e forma:SolidPeso molecolare:465.34STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Formula:C28H25ClN6O5Colore e forma:SolidPeso molecolare:560.988XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Formula:C24H20N4O2SColore e forma:SolidPeso molecolare:428.51COX-2-IN-6
CAS:<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Formula:C20H27NO6SPurezza:99.29% - 99.69%Colore e forma:SoildPeso molecolare:409.5COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formula:C15H10ClIN2OColore e forma:SolidPeso molecolare:396.61COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formula:C22H23FN2O6S2Colore e forma:SolidPeso molecolare:494.56(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formula:C16H14O3Colore e forma:SolidPeso molecolare:254.28Ambuic acid
CAS:<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formula:C19H26O6Colore e forma:SolidPeso molecolare:350.41
