CaMK
Gli inibitori della Protein-Chinasi Dipendente dal Calcio/Calmodulina (CaMK) sono composti specializzati che inibiscono l'attività della CaMK, una chinasi critica coinvolta in una varietà di processi cellulari, in particolare nel sistema nervoso. La CaMK è essenziale per tradurre i segnali di calcio in varie risposte cellulari, tra cui la plasticità sinaptica, la formazione della memoria e l'espressione genica. La disregolazione dell'attività della CaMK è associata a numerosi disturbi neurologici, rendendo questi inibitori strumenti preziosi per lo studio della segnalazione sinaptica, dell'apprendimento e della memoria. Presso CymitQuimica, offriamo inibitori della CaMK di alta qualità per supportare la tua ricerca sulla plasticità sinaptica, la funzione cognitiva e la neurofarmacologia.
Trovati 72 prodotti di "CaMK"
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A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formula:C12H14Cl2N2O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:321.22Elziverine
CAS:<p>Elziverine: oral calmodulin antagonist, inhibits Ca-induced acanthocyte formation, potential for neurological and cognitive disorder treatment.</p>Formula:C32H37N3O5Purezza:99.79%Colore e forma:SolidPeso molecolare:543.65Dibucaine
CAS:<p>Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.</p>Formula:C20H29N3O2Purezza:99.698% - 99.88%Colore e forma:Colorless Or Almost Colorless Powder SolidPeso molecolare:343.46Y-33075 dihydrochloride
CAS:<p>Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).</p>Formula:C16H18Cl2N4OPurezza:98.88% - 99.89%Colore e forma:SolidPeso molecolare:353.25Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurezza:99.57% - 99.96%Colore e forma:Cream Fine PowderPeso molecolare:480.43Fluphenazine-N-2-chloroethane (hydrochloride)
CAS:Fluphenazine: antipsychotic, binds dopamine D2 (Ki=0.55nM), inhibits calmodulin. Its derivative adds irreversible D2 antagonism and anticancer potential.Formula:C22H27Cl3F3N3SColore e forma:SolidPeso molecolare:528.89CaMKIIα-PHOTAC
<p>CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα).</p>Formula:C54H58Cl2N10O11Purezza:98%Colore e forma:SolidPeso molecolare:1094TAT-CN21
<p>TatCN21, with an IC 50 of 77 nM, serves as a potent and selective inhibitor peptide of the calcium/calmodulin-dependent protein kinase II (CaMKII), a ubiquitously-expressed multifunctional serine/threonine protein kinase. It is particularly useful in research pertaining to ischemia and neurodegenerative diseases.</p>Formula:C169H303N69O43Colore e forma:SolidPeso molecolare:3989.65Calmodulin Kinase IINtide, Myristoylated
Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].Formula:C156H275N47O43Purezza:98%Colore e forma:SolidPeso molecolare:3497.14TAT-CN21 (scrambled)
TAT-CN21(scrambled) is a control peptide lacking specific targeting activity and serves as a negative control for TatCN21. TatCN21 is an effective and selective inhibitory peptide for calcium/calmodulin-dependent protein kinase II (CaMKII).Colore e forma:Odour SolidAC3-I, myristoylated
<p>Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I).</p>Formula:C78H137N21O20Purezza:98%Colore e forma:SolidPeso molecolare:1689.05Beauverolide Ja
CAS:Beauverolide Ja: cyclotetradepsipeptide, CaM inhibitor; Kd 0.078 μM, Ki 0.39 μM; from Isaria fumosorosea.Formula:C35H46N4O5Colore e forma:SolidPeso molecolare:602.76CALP2
CAS:CALP2 is a CaM antagonist blocking EF-hand/Ca2+ site; inhibits CaM phosphodiesterase, raises Ca2+, and activates alveolar macrophages.Formula:C68H104N14O13SPurezza:98%Colore e forma:SolidPeso molecolare:1357.72Calmodulin-Dependent Protein Kinase II (281-309)
CAS:Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).Formula:C146H254N46O39S3Purezza:98%Colore e forma:SolidPeso molecolare:3374.06Acremonidin A
CAS:Acremonidin A, from Purpureocillium lilacinum, is a strong CaM inhibitor binding to hCaM M124C-mBBr with a Kd of 19.40 nM.Formula:C33H26O12Colore e forma:SolidPeso molecolare:614.55Fasciculic acid C
CAS:Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Formula:C38H63NO11Purezza:98%Colore e forma:SolidPeso molecolare:709.91Fasciculic acid A
CAS:Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Formula:C36H60O8Colore e forma:SolidPeso molecolare:620.868RA306
RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.Colore e forma:Odour SolidCalmodulin Binding Peptide 1
CAS:<p>Calmodulin Binding Peptide 1, a high-affinity MLCK-derived inhibitor, blocks IP3-induced Ca2+ release.</p>Formula:C231H373N69O70S2Purezza:98%Colore e forma:SolidPeso molecolare:5301.1Fasciculic acid B
CAS:Fasciculic acid B: ester of fasciculol B, 3-hydroxy-methylglutaric acid; a calmodulin antagonist from Naematoloma fasciculare.Formula:C36H60O9Purezza:98%Colore e forma:SolidPeso molecolare:636.86Calmodulin-Dependent Protein Kinase II 290-309 acetate
Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).Formula:C105H189N31O26SPurezza:96.7%Colore e forma:SolidPeso molecolare:2333.88Encecalinol
CAS:Encecalinol, a compound isolated from the aerial parts of Ageratina grandifolia, acts as a potent inhibitor of calmodulin [1].Formula:C14H18O3Colore e forma:SolidPeso molecolare:234.29CALP2 TFA
CALP2 TFA, a CaM antagonist with 7.9 µM Kd, blocks CaM-dependent enzymes, boosts Ca2+ levels, and activates macrophages.Formula:C70H105F3N14O15SColore e forma:SolidPeso molecolare:1471.72Cloxacepride
CAS:<p>cloxacepride is a CaM antagonist that is used to treat asthma disease.</p>Formula:C22H27Cl2N3O4Purezza:99.62%Colore e forma:SolidPeso molecolare:468.37Purine riboside-5'-O-triphosphate sodium
CAS:Purine riboside-5'-O-triphosphate sodium is an active metabolite of Nebularine (HY-103694) and acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM, respectively. It also inhibits calmodulin-dependent protein kinase II (CaMKII), with a Ki value of 590 µM.Formula:C10H11N4Na4O13P3Peso molecolare:580.09Syntide 2 TFA
Syntide 2 (TFA) is a CaMKII substrate that selectively hinders GA response without affecting other plant processes.Formula:C70H123N20F3O20Colore e forma:SolidPeso molecolare:1621.84CAMKIV Protein, Human, Recombinant (GST)
CAMKIV Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.Colore e forma:Lyophilized PowderPeso molecolare:79 kDa (predicted); 100 kDa (reducing conditions)NH125
CAS:<p>NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.</p>Formula:C27H45IN2Purezza:98.60%Colore e forma:SolidPeso molecolare:524.56CALP2 acetate(261969-04-4 free base)
<p>CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM.</p>Formula:C68H104N14O13SPurezza:97.43%Colore e forma:SolidPeso molecolare:1357.7Syntide 2 acetate(108334-68-5 free base)
Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).Formula:C70H126N20O20Purezza:99.74%Colore e forma:SolidPeso molecolare:1567.85Autocamtide-2-related inhibitory peptide
CAS:<p>Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formula:C64H116N22O19Purezza:>99.99%Colore e forma:SolidPeso molecolare:1497.74Autocamtide 2 TFA(129198-88-5 free base)
<p>Autocamtide 2 TFA, selective CaMKII peptide substrate, used in its activity assay.</p>Formula:C67H119F3N22O22Purezza:98%Colore e forma:SolidPeso molecolare:1641.79CaMKP Inhibitor
CAS:<p>CaMKP Inhibitor can inhibit CaMKP.</p>Formula:C10H8NNaO7S2Purezza:96.55% - 99.98%Colore e forma:SolidPeso molecolare:341.28GSK3i XIII
CAS:GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.Formula:C18H19N5Purezza:98.87%Colore e forma:SolidPeso molecolare:305.38IGS-1.76
CAS:IGS-1.76 binds strongly to hNCS-1, modulates its Ric8a interaction, and inhibits the hNCS-1/Ric8a complex.Formula:C22H18N2OSPurezza:98.18% - 98.56%Colore e forma:SolidPeso molecolare:358.46KN-92
CAS:KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93.Formula:C24H25ClN2O3SColore e forma:SolidPeso molecolare:456.98KN-93
CAS:<p>KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.</p>Formula:C26H29ClN2O4SPurezza:99.56% - 99.86%Colore e forma:White SolidPeso molecolare:501.04Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurezza:98.3% - 99.46%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:407.5CALP1 acetate
<p>CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site.</p>Formula:C42H79N9O12Purezza:99.63%Colore e forma:SolidPeso molecolare:902.13CaMKII-IN-1
CAS:CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM).Formula:C29H30ClN5O2SPurezza:99.69%Colore e forma:SolidPeso molecolare:548.1lavendustin C
CAS:lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Formula:C14H13NO5Purezza:98.06%Colore e forma:Yellow To Tan PowderPeso molecolare:275.26STO-609
CAS:<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formula:C19H10N2O3Purezza:97.14% - 98.8%Colore e forma:SolidPeso molecolare:314.29KN-62
CAS:<p>KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.</p>Formula:C38H35N5O6S2Purezza:99.80% - >99.99%Colore e forma:White SolidPeso molecolare:721.84KN-92 hydrochloride
CAS:<p>KN-92 hydrochloride is an inactive derivative of KN-93.</p>Formula:C24H26Cl2N2O3SPurezza:99.68%Colore e forma:SolidPeso molecolare:493.45A-484954
CAS:A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.Formula:C13H15N5O3Purezza:97.47% - 99.86%Colore e forma:SolidPeso molecolare:289.29CaM kinase II inhibitor TFA salt
<p>CaM kinase II inhibitor TFA salt (Autocamtide-2-related inhibitory peptide (TFA)) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formula:C66H117F3N22O21Purezza:>99.99%Colore e forma:SolidPeso molecolare:1611.77L-6355
CAS:L-6355 is an agent of bioactive chemicals.Formula:C25H30INO3Colore e forma:SolidPeso molecolare:519.42Zaldaride maleate
CAS:Zaldaride maleate blocks Ca2+, Na+, K+ currents, and nAChR; inhibits CaM cAMP PDE (IC50: 3.3 nM) and estrogen signaling.Formula:C30H32N4O6Purezza:98%Colore e forma:SolidPeso molecolare:544.6TX-1123
CAS:TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.Formula:C20H24O3Colore e forma:SolidPeso molecolare:312.4Prenylamine lactate
CAS:Prenylamine lactate, an ex-angina drug, depletes heart catecholamines and blocks calcium channels.Formula:C27H33NO3Purezza:98%Colore e forma:SolidPeso molecolare:419.56A-7 hydrochloride
CAS:<p>A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.</p>Formula:C20H30Cl2N2O2SPurezza:99.38%Colore e forma:SolidPeso molecolare:433.44CBP501
CAS:CBP501 peptide inhibits kinases like MAPKAP-K2/C-Tak1/CHK1, preventing Cdc25C function and blocking the entry into mitosis.Formula:C86H122F5N29O17Colore e forma:SolidPeso molecolare:1929.06TIM-063
CAS:TIM-063: ATP-competitive CaMKKα/β inhibitor, cell-permeable, Ki: 0.35/0.2 μM, IC50: 0.63/0.96 μM.Formula:C18H9N3O4Colore e forma:SolidPeso molecolare:331.28Ph-HTBA
CAS:Ph-HTBA: high-affinity CaMKIIα modulator, brain-penetrant, Kd 757 nM, used in ischemia/neurodegeneration research.Formula:C19H18O3Colore e forma:SolidPeso molecolare:294.34Bisindolylmaleimide VII
CAS:Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.Formula:C27H27N5O2Colore e forma:SolidPeso molecolare:453.54CK59
CAS:CK59 inhibits CaMKII and several voltage-gated calcium channels, with an IC50 of ~50 μM.Formula:C21H37N7O3Purezza:98%Colore e forma:SolidPeso molecolare:435.56RU 45144
CAS:<p>RU 45144 is an estradiol derivative with antiestrogenic activity.</p>Formula:C28H37NO3Purezza:98%Colore e forma:SolidPeso molecolare:435.6W-13 hydrochloride
CAS:<p>W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.</p>Formula:C14H18Cl2N2O2SPurezza:98.51%Colore e forma:White PowderPeso molecolare:349.28HOCPCA
CAS:HOCPCA: potent, selective GHB site ligand; 27x higher affinity than GHB; crosses blood-brain barrier.Formula:C6H8O3Purezza:98%Colore e forma:SolidPeso molecolare:128.13CV-159
CAS:CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.Formula:C31H34N4O7Purezza:98%Colore e forma:SolidPeso molecolare:574.62W-5 hydrochloride
CAS:<p>W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.</p>Formula:C16H23ClN2O2SPurezza:99.35%Colore e forma:Off-White Crystalline SolidPeso molecolare:342.88W-9 hydrochloride
CAS:<p>W-9 hydrochloride is a calmodulin antagonist.</p>Formula:C16H22Cl2N2O2SPurezza:98.9%Colore e forma:SolidPeso molecolare:377.33Zaldaride (free base)
CAS:Zaldaride (free base) is a calmodulin antagonist.Formula:C26H28N4O2Colore e forma:SolidPeso molecolare:428.53Calmidazolium chloride
CAS:Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.Formula:C31H23Cl7N2OPurezza:98.53%Colore e forma:SolidPeso molecolare:687.7FO-4-15
CAS:FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.Formula:C18H20N4O4SColore e forma:SolidPeso molecolare:388.44CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Formula:C14H11ClO4Colore e forma:SolidPeso molecolare:278.69Aprindine
CAS:Aprindine, an arrhythmia inhibitor, stabilizes the cell membranes of heart muscle cells to prevent abnormal electrical impulses and irregular heartbeats. In hematological toxicity studies, aprindine demonstrated potential inhibitory effects on the replicative capacity of mouse and human blood cells at specific concentrations [1].Formula:C22H30N2Peso molecolare:322.49CaMKK2-IN-1
CAS:CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.Formula:C22H22N2O3Peso molecolare:362.42BRD0418
CAS:<p>BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.</p>Formula:C29H32N2O5Purezza:99.57%Colore e forma:SolidPeso molecolare:488.57PTCA
CAS:PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.Formula:C10H5Cl2NO2SColore e forma:SolidPeso molecolare:274.123MCB-22-174
CAS:MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP).Formula:C16H14DCl2N5OS2Peso molecolare:429.37Calmodulin antagonist-1
CAS:Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.Formula:C14H18Cl2N2O2SColore e forma:SolidPeso molecolare:349.27
