CaMK
Gli inibitori della Protein-Chinasi Dipendente dal Calcio/Calmodulina (CaMK) sono composti specializzati che inibiscono l'attività della CaMK, una chinasi critica coinvolta in una varietà di processi cellulari, in particolare nel sistema nervoso. La CaMK è essenziale per tradurre i segnali di calcio in varie risposte cellulari, tra cui la plasticità sinaptica, la formazione della memoria e l'espressione genica. La disregolazione dell'attività della CaMK è associata a numerosi disturbi neurologici, rendendo questi inibitori strumenti preziosi per lo studio della segnalazione sinaptica, dell'apprendimento e della memoria. Presso CymitQuimica, offriamo inibitori della CaMK di alta qualità per supportare la tua ricerca sulla plasticità sinaptica, la funzione cognitiva e la neurofarmacologia.
Trovati 72 prodotti di "CaMK"
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W-13 hydrochloride
CAS:W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.Formula:C14H18Cl2N2O2SPurezza:98.51%Colore e forma:White PowderPeso molecolare:349.28W-5 hydrochloride
CAS:W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.Formula:C16H23ClN2O2SPurezza:99.35%Colore e forma:Off-White Crystalline SolidPeso molecolare:342.88TX-1123
CAS:TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.Formula:C20H24O3Colore e forma:SolidPeso molecolare:312.4A-7 hydrochloride
CAS:<p>A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.</p>Formula:C20H30Cl2N2O2SPurezza:99.38%Colore e forma:SolidPeso molecolare:433.44CBP501
CAS:CBP501 peptide inhibits kinases like MAPKAP-K2/C-Tak1/CHK1, preventing Cdc25C function and blocking the entry into mitosis.Formula:C86H122F5N29O17Colore e forma:SolidPeso molecolare:1929.06TIM-063
CAS:TIM-063: ATP-competitive CaMKKα/β inhibitor, cell-permeable, Ki: 0.35/0.2 μM, IC50: 0.63/0.96 μM.Formula:C18H9N3O4Colore e forma:SolidPeso molecolare:331.28Ph-HTBA
CAS:Ph-HTBA: high-affinity CaMKIIα modulator, brain-penetrant, Kd 757 nM, used in ischemia/neurodegeneration research.Formula:C19H18O3Colore e forma:SolidPeso molecolare:294.34Bisindolylmaleimide VII
CAS:Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.Formula:C27H27N5O2Colore e forma:SolidPeso molecolare:453.54CK59
CAS:CK59 inhibits CaMKII and several voltage-gated calcium channels, with an IC50 of ~50 μM.Formula:C21H37N7O3Purezza:98%Colore e forma:SolidPeso molecolare:435.56RU 45144
CAS:RU 45144 is an estradiol derivative with antiestrogenic activity.Formula:C28H37NO3Purezza:98%Colore e forma:SolidPeso molecolare:435.6HOCPCA
CAS:HOCPCA: potent, selective GHB site ligand; 27x higher affinity than GHB; crosses blood-brain barrier.Formula:C6H8O3Purezza:98%Colore e forma:SolidPeso molecolare:128.13W-9 hydrochloride
CAS:<p>W-9 hydrochloride is a calmodulin antagonist.</p>Formula:C16H22Cl2N2O2SPurezza:98.9%Colore e forma:SolidPeso molecolare:377.33Ref: TM-T23525
1mg35,00€2mg44,00€5mg64,00€10mg96,00€25mg183,00€50mg284,00€100mg411,00€500mgPrezzo su richiestaCalmidazolium chloride
CAS:Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.Formula:C31H23Cl7N2OPurezza:98.53%Colore e forma:SolidPeso molecolare:687.7Ref: TM-T10667
5mg63,00€10mg87,00€25mg145,00€50mg215,00€100mg320,00€200mg467,00€1mL*10mM (DMSO)95,00€Zaldaride (free base)
CAS:Zaldaride (free base) is a calmodulin antagonist.Formula:C26H28N4O2Colore e forma:SolidPeso molecolare:428.53Aprindine
CAS:Aprindine, an arrhythmia inhibitor, stabilizes the cell membranes of heart muscle cells to prevent abnormal electrical impulses and irregular heartbeats. In hematological toxicity studies, aprindine demonstrated potential inhibitory effects on the replicative capacity of mouse and human blood cells at specific concentrations [1].Formula:C22H30N2Peso molecolare:322.49MCB-22-174
CAS:MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP).Formula:C16H14DCl2N5OS2Peso molecolare:429.37PTCA
CAS:PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.Formula:C10H5Cl2NO2SColore e forma:SolidPeso molecolare:274.123CaMKK2-IN-1
CAS:CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.Formula:C22H22N2O3Peso molecolare:362.42BRD0418
CAS:<p>BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.</p>Formula:C29H32N2O5Purezza:99.57%Colore e forma:SolidPeso molecolare:488.57FO-4-15
CAS:FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.Formula:C18H20N4O4SColore e forma:SolidPeso molecolare:388.44CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Formula:C14H11ClO4Colore e forma:SolidPeso molecolare:278.69Calmodulin antagonist-1
CAS:Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.Formula:C14H18Cl2N2O2SColore e forma:SolidPeso molecolare:349.27
