
GluR
Gli inibitori dei recettori del glutammato sono composti che bloccano l'attività dei recettori del glutammato, i principali recettori dei neurotrasmettitori eccitatori nel cervello. Questi recettori svolgono un ruolo cruciale nella trasmissione sinaptica, nella plasticità, nell'apprendimento e nella memoria. La disregolazione della segnalazione del glutammato è associata a vari disturbi neurologici, come l'epilessia, l'ictus e le malattie neurodegenerative. Gli inibitori dei recettori del glutammato sono essenziali per studiare i meccanismi dell'eccitotossicità e sviluppare strategie neuroprotettive. Presso CymitQuimica, offriamo una gamma di inibitori dei recettori del glutammato per supportare la vostra ricerca sulla funzione sinaptica, la neuroprotezione e i disturbi cognitivi.
Trovati 263 prodotti per "GluR".
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Talaglumetad hydrochloride
CAS:Talaglumetad hydrochloride, a prodrug of Eglumegad, targets mGluR2/3 to treat psychiatric disorders.Formula:C11H17ClN2O5Colore e forma:SolidPeso molecolare:292.72MGS-0039
CAS:MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.Formula:C15H14Cl2FNO5Purezza:98%Colore e forma:SolidPeso molecolare:378.18MFZ 10-7
CAS:MFZ 10-7 is anegative allosteric modulator of the mGluR5.Formula:C15H9FN2Purezza:99.80%Colore e forma:Yellow SolidPeso molecolare:236.24Philanthotoxin 74 dihydrochloride
CAS:Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.Formula:C24H44Cl2N4O3Purezza:99.75%Colore e forma:White SolidPeso molecolare:507.54VU6004909
CAS:VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.Formula:C21H15FN2O4Purezza:96.68% - 98.44%Colore e forma:SolidPeso molecolare:378.35Azotomycin
CAS:Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.Formula:C17H23N7O8Purezza:98%Colore e forma:SolidPeso molecolare:453.41STAT3-IN-36
CAS:STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.Formula:C30H24F2N2O9S2Colore e forma:SolidPeso molecolare:658.65BTB01303
CAS:BTB01303 is a glutamate release inhibitor that targets the high levels of glutamate released by cancer cells, which disrupts normal bone turnover and can lead to cancer-induced bone pain. BTB01303 has the potential to improve cancer-induced bone pain [1].Formula:C15H11Cl2NO3Colore e forma:SolidPeso molecolare:324.16YM-202074
CAS:YM-202074: Selective mGlu1 antagonist, binds allosteric site (Ki=4.8 nM), inhibits mGlu1 (IC50=8.6 nM).Formula:C22H30N4O2SColore e forma:SolidPeso molecolare:414.56CVN636
CAS:CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for humanFormula:C19H20FNO4SColore e forma:SolidPeso molecolare:377.43LY367385 hydrochloride
CAS:LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.Formula:C10H12ClNO4Colore e forma:SolidPeso molecolare:245.66LY-2979165
CAS:LY-2979165 is a metabotropic glutamate receptor agonist prodrug.Formula:C13H17N5O5SColore e forma:SolidPeso molecolare:355.37FP0429
CAS:FP0429 is an agonist of mGlu4.Formula:C10H12N2O7Purezza:98%Colore e forma:SolidPeso molecolare:272.21CPPG
CAS:CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.Formula:C11H14NO5PColore e forma:SolidPeso molecolare:271.21LY 541850
CAS:LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from humanFormula:C9H13NO4Purezza:98%Colore e forma:SolidPeso molecolare:199.2YM 202074
CAS:metabotropic glutamate receptor type 1 (mGlu1) antagonistFormula:C56H72N8O16S2Purezza:98%Colore e forma:SolidPeso molecolare:1177.34LY3020371 hydrochloride
CAS:LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Formula:C15H16ClF2NO5SColore e forma:SolidPeso molecolare:395.81Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Formula:C12H20N2O8S2Purezza:98%Colore e forma:SolidPeso molecolare:384.43LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Formula:C16H18N2O6Purezza:98.15%Colore e forma:White SolidPeso molecolare:334.32PF470
CAS:PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.Formula:C18H16N6OColore e forma:SolidPeso molecolare:332.36
