AChR
Gli inibitori del recettore dell'acetilcolina (AChR) sono composti che bloccano l'attività dei recettori dell'acetilcolina, fondamentali per la neurotrasmissione nei sistemi nervoso centrale e periferico. Gli AChR svolgono un ruolo cruciale nella contrazione muscolare, nella memoria e nelle funzioni cognitive. Gli inibitori degli AChR vengono utilizzati per studiare condizioni come la miastenia grave, l'Alzheimer e altri disturbi neurologici. Modulando l'attività degli AChR, questi inibitori possono aiutare a svelare le complessità della segnalazione colinergica nel cervello. Presso CymitQuimica, offriamo una gamma di inibitori degli AChR per supportare la tua ricerca in neuroscienze, farmacologia e malattie neurodegenerative.
Trovati 642 prodotti di "AChR"
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Timepidium bromide
CAS:Timepidium bromide is an agent of anticholinergic.Formula:C17H22BrNOS2Purezza:98%Colore e forma:SolidPeso molecolare:400.4Tiotropium Bromide hydrate
CAS:Tiotropium Bromide hydrate is a potent, long-lasting anticholinergic bronchodilator for COPD, with high affinity for muscarinic receptors M1, M2, and M3.Formula:C19H24BrNO5S2Purezza:98.44% - 99.41%Colore e forma:SolidPeso molecolare:490.43ICL-CCIC-0019
CAS:ICL-CCIC-0019 inhibits ChoKα, causes G1 arrest, ER stress, and cancer cell apoptosis.Formula:C26H44Br2N4Purezza:99.54%Colore e forma:SolidPeso molecolare:572.46Ref: TM-T27579
2mg43,00€5mg70,00€10mg92,00€25mg132,00€50mg200,00€100mg344,00€200mg505,00€1mL*10mM (DMSO)88,00€VU0453595
CAS:VU0453595 is a M1 positive allosteric modulator (PAM).
Formula:C18H15FN4OPurezza:99.91%Colore e forma:SolidPeso molecolare:322.34N-Demethyl MK-6884
CAS:N-Demethyl MK-6884 (compound 34) is an M4 mAChR modulator for Alzheimer's and related disease research.Formula:C24H23N5OColore e forma:SolidPeso molecolare:397.47Hydroxy Varenicline
CAS:Hydroxy varenicline, a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline, functions within the biochemical pathway by interacting with nAChR sites.Formula:C13H13N3OColore e forma:SolidPeso molecolare:227.267VU6007477
CAS:VU6007477 is a brain-penetrant M1 muscarinic receptor PAM (EC50 230 nM) used for research on CNS exposure and seizure-related models.Formula:C24H26N6O2Purezza:99.67%Colore e forma:SolidPeso molecolare:430.5Tolterodine Dimer
CAS:Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder.Formula:C35H41NO2Colore e forma:SolidPeso molecolare:507.713-Bromocytisine
CAS:3-Bromocytisine ((-)-3-Bromocytisine) is an effective agonist of nAChR (IC50s: 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7).Formula:C11H13BrN2OPurezza:99.974%Colore e forma:SolidPeso molecolare:269.14Ref: TM-T10108
1mg95,00€5mg202,00€10mg293,00€25mg494,00€50mg710,00€100mg973,00€200mg1.305,00€1mL*10mM (DMSO)178,00€ASP8302
CAS:ASP8302 is an allosteric potentiator of the muscarinic M3 receptor. It enhances urination efficiency and reduces residual urine volume in two rat models of voiding dysfunction. ASP8302 is useful for investigating diseases associated with bladder dysfunction.Formula:C26H32ClN7O3S2Colore e forma:SolidPeso molecolare:590.16Cynandione A
CAS:Cynandione A is an acetophenone derived from Cynanchum wilfordii with anti-inflammatory activity.Formula:C16H14O6Purezza:99.62%Colore e forma:SolidPeso molecolare:302.28APS3
CAS:APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].Formula:C18H7Cl2F6N5O5S2Colore e forma:SolidPeso molecolare:622.31UFP-512
CAS:UFP-512 is a selective delta-opioid (DOP) receptor agonist.Formula:C31H33N5O5Purezza:98%Colore e forma:SolidPeso molecolare:555.62A-424274
CAS:A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.Formula:C14H15N3Purezza:98%Colore e forma:SolidPeso molecolare:225.29Tematropium
CAS:Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.Formula:C21H31NO8SPurezza:99.89%Colore e forma:SolidPeso molecolare:457.54Ref: TM-T10732
1mg147,00€5mg356,00€10mg558,00€25mg880,00€50mg1.179,00€100mg1.603,00€200mg2.152,00€1mL*10mM (DMSO)413,00€(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.Formula:C10H19ClNO1·5SPurezza:98%Colore e forma:SolidPeso molecolare:244.78Dihydro-β-erythroidine
CAS:Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolyticFormula:C16H21NO3Colore e forma:SolidPeso molecolare:275.34TDI-11861
CAS:TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.Formula:C22H25ClF2N6O3Colore e forma:SolidPeso molecolare:494.92VU6005806
CAS:VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.Formula:C17H16F3N7O2SPurezza:98%Colore e forma:SolidPeso molecolare:439.41Dihydro-β-erythroidine hydrobromide
CAS:Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).Formula:C16H22BrNO3Purezza:98%Colore e forma:White SolidPeso molecolare:356.26VU6016235
CAS:VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.Formula:C21H22N4OSColore e forma:SolidPeso molecolare:378.491,9-Dideoxyforskolin
CAS:The compound is an inactive analog of forskolin(an adenylyl cyclase activator).Formula:C22H34O5Purezza:98%Colore e forma:SolidPeso molecolare:378.5Acetylethylcholine mustard hydrochloride
CAS:Acetylethylcholine mustard hydrochloride is a choline acetyl-transferase inhibitor that decreases muscle contraction frequency by inhibiting the synthesis of acetyl-beta-methylcholine (Ach), with a half-maximal inhibitory concentration (IC50) of 1.22 mM. It serves as an irreversible ligand for the high-affinity choline transport system and functions as a specific presynaptic long-acting cholinergic toxin. Additionally, acetylethylcholine mustard hydrochloride is a precursor to the ethylcholine mustard aziridinium ion.Formula:C8H17Cl2NO2Peso molecolare:230.132Lu 26-046
CAS:Lu 26-046 is a muscarinic receptor agonist.Formula:C10H12N2OSColore e forma:SolidPeso molecolare:208.28Metoquizine
CAS:Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.Formula:C22H27N5OPurezza:98%Colore e forma:SolidPeso molecolare:377.48VU6007496
CAS:VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).Formula:C25H27N5O2Colore e forma:SolidPeso molecolare:429.51TAAR1 agonist 2
CAS:TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.Formula:C9H11NOColore e forma:SolidPeso molecolare:149.19(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.Formula:C10H19ClNO1·5SPurezza:98%Colore e forma:SolidPeso molecolare:244.78WIN 62577
CAS:WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.Formula:C29H31N3OColore e forma:SolidPeso molecolare:437.576p-F-HHSiD hydrochloride
CAS:p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3mAChR antagonist. It is capable of inhibiting acetylcholine-mediated vasodilation in human umbilical vein endothelial cells (HUVEC).Formula:C20H33ClFNOSiPeso molecolare:386.019YM-49598 iodide
CAS:YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.Formula:C36H45Cl2IN2O2Colore e forma:SolidPeso molecolare:735.57LY593093
CAS:LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.Formula:C32H30FN3O2Purezza:98%Colore e forma:SolidPeso molecolare:507.6CHF-6366
CAS:CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.Formula:C42H48N6O8Colore e forma:SolidPeso molecolare:764.87(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.Formula:C15H38N2O9SColore e forma:SolidPeso molecolare:422.54nAChR antagonist 1
CAS:Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Formula:C19H22N4O2Colore e forma:SolidPeso molecolare:338.4(S)-Albuterol
CAS:(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.Formula:C13H21NO3Colore e forma:SolidPeso molecolare:239.311UB 165
CAS:Subtype-selective nicotinic agonistFormula:C13H15ClN2Purezza:98%Colore e forma:SolidPeso molecolare:234.72AChE/BChE-IN-10
CAS:AChE/BChE-IN-10 inhibits AChE/BChE (IC50: 0.176/0.47 μM), crosses the blood-brain barrier, and prevents Aβ-aggregation.
Formula:C26H30N2O2Purezza:99.55% - 99.88%Colore e forma:SoildPeso molecolare:402.53VU6000918
CAS:VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.Formula:C18H17F2N5OSColore e forma:SolidPeso molecolare:389.42Lupinine
CAS:Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and Lupinus. It may also inhibit heparin.
Formula:C10H19NOPurezza:99.95%Colore e forma:SolidPeso molecolare:169.26Oxitropium Bromide
CAS:Oxitropium bromide, a mAChR blocker, treats asthma and COPD as an anticholinergic bronchodilator.Formula:C19H26BrNO4Purezza:98%Colore e forma:SolidPeso molecolare:412.32Ref: TM-T16417
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