AChR
Gli inibitori del recettore dell'acetilcolina (AChR) sono composti che bloccano l'attività dei recettori dell'acetilcolina, fondamentali per la neurotrasmissione nei sistemi nervoso centrale e periferico. Gli AChR svolgono un ruolo cruciale nella contrazione muscolare, nella memoria e nelle funzioni cognitive. Gli inibitori degli AChR vengono utilizzati per studiare condizioni come la miastenia grave, l'Alzheimer e altri disturbi neurologici. Modulando l'attività degli AChR, questi inibitori possono aiutare a svelare le complessità della segnalazione colinergica nel cervello. Presso CymitQuimica, offriamo una gamma di inibitori degli AChR per supportare la tua ricerca in neuroscienze, farmacologia e malattie neurodegenerative.
Trovati 618 prodotti di "AChR"
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Temiverine hydrochloride
CAS:Temiverine hydrochloride is a potential calcium channel antagonist with anticholinergic effects that inhibits some of the functions of atropine.Formula:C24H36ClNO3Purezza:99.26% - 99.43%Colore e forma:SolidPeso molecolare:422Iperoxo
CAS:Iperoxo (Iperoxo iodide) is an agonist of Muscarinic AChR and can be used to probe activation-related conformational transitions of muscarinic receptors.Formula:C10H17IN2O2Purezza:99.81%Colore e forma:SolidPeso molecolare:324.16McN-A 343
CAS:<p>McN-A 343: Selective M1 muscarinic agonist; reduces inflammation in colitis models.</p>Formula:C14H18Cl2N2O2Purezza:99.65%Colore e forma:SolidPeso molecolare:317.21ASM-024
CAS:ASM-024, a synthetic piperazine, activates nicotinic and β2-adrenergic receptors for potential asthma and bronchitis treatment with anti-inflammatory effects.Formula:C15H25N2Purezza:99.74%Colore e forma:SolidPeso molecolare:233.37Tribendimidine
CAS:<p>Tribendimidine: broad-spectrum oral anthelmintic, nAChR agonist, effective against A. lumbricoides and N. americanus.</p>Formula:C28H32N6Purezza:≥98%Colore e forma:SolidPeso molecolare:452.59AQW051
CAS:AQW051 (VQW-765) is an oral α7-nAChR activator for cognitive impairments, used in anxiety disorder studies.Formula:C19H22N2OPurezza:99.94%Colore e forma:SolidPeso molecolare:294.39rel-(1R,2R)-Vesamicol Hydrochloride
CAS:rel-(1R,2R)-Vesamicol Hydrochloride is a acetylcholine transport inhibitor.Formula:C17H26ClNOPurezza:99.88%Colore e forma:SolidPeso molecolare:295.85PHA 543613
CAS:PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.Formula:C15H17N3O2Purezza:99.43% - 99.96%Colore e forma:SolidPeso molecolare:271.31Oxotremorine M iodide
CAS:Oxotremorine M iodide (Oxotremorine methiodide) is an agonist of mAChR and potentiates NMDA receptors.Formula:C11H19IN2OPurezza:99.57%Colore e forma:SolidPeso molecolare:322.19Aceclidine
CAS:Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocularFormula:C9H15NO2Purezza:>99.99%Colore e forma:SolidPeso molecolare:169.22JNJ-39393406
CAS:JNJ-39393406 is an α7 nicotinic acetylcholine receptor positive allosteric modulator for the study of tobacco dependence and Alzheimer's disease.Formula:C19H18F2N6O3Purezza:98.5%Colore e forma:SolidPeso molecolare:416.38NB001
CAS:NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.Formula:C12H20N6OPurezza:99.69%Colore e forma:Off-White To Pale Pink SolidPeso molecolare:264.33Otenzepad
CAS:Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.Formula:C24H31N5O2Purezza:99.79%Colore e forma:SolidPeso molecolare:421.54Dimethindene
CAS:Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.Formula:C20H24N2Purezza:98.3% - 98.99%Colore e forma:SolidPeso molecolare:292.42N-Demethyl MK-6884
CAS:N-Demethyl MK-6884 (compound 34) is an M4 mAChR modulator for Alzheimer's and related disease research.Formula:C24H23N5OColore e forma:SolidPeso molecolare:397.47APS3
CAS:APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].Formula:C18H7Cl2F6N5O5S2Colore e forma:SolidPeso molecolare:622.31Adenylyl cyclase-IN-1
CAS:Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1].Formula:C9H8N2S3Colore e forma:SolidPeso molecolare:240.37ICL-CCIC-0019
CAS:<p>ICL-CCIC-0019 inhibits ChoKα, causes G1 arrest, ER stress, and cancer cell apoptosis.</p>Formula:C26H44Br2N4Purezza:99.54%Colore e forma:SolidPeso molecolare:572.463-Bromocytisine
CAS:3-Bromocytisine ((-)-3-Bromocytisine) is an effective agonist of nAChR (IC50s: 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7).Formula:C11H13BrN2OPurezza:99.974%Colore e forma:SolidPeso molecolare:269.14Homatropine hydrochloride
CAS:Homatropine hydrochloride is an orally active anticholinergic agent that induces rapid pupil dilation with cycloplegic effects and possesses antitussiveFormula:C16H22ClNO3Colore e forma:SolidPeso molecolare:311.8Tiotropium Bromide hydrate
CAS:Tiotropium Bromide hydrate is a potent, long-lasting anticholinergic bronchodilator for COPD, with high affinity for muscarinic receptors M1, M2, and M3.Formula:C19H24BrNO5S2Purezza:98.44% - 99.41%Colore e forma:SolidPeso molecolare:490.43mAChR antagonist 1
CAS:Compound 4a, a mAChR antagonist, exhibits K i values of 255 nM for M1 and M5 subtypes, and lower values of 121 nM and 158 nM for M3 and M4 subtypes,Formula:C19H22N2O2Colore e forma:SolidPeso molecolare:310.39Tolterodine Dimer
CAS:Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder.Formula:C35H41NO2Colore e forma:SolidPeso molecolare:507.71AR420626
CAS:AR420626: selective FA3R agonist, guards against SALS, effects blocked by BHB, a FA3R antagonist.Formula:C21H18Cl2N2O3Purezza:98.62%Colore e forma:SolidPeso molecolare:417.29ASP8302
CAS:ASP8302 is an allosteric potentiator of the muscarinic M3 receptor. It enhances urination efficiency and reduces residual urine volume in two rat models of voiding dysfunction. ASP8302 is useful for investigating diseases associated with bladder dysfunction.Formula:C26H32ClN7O3S2Colore e forma:SolidPeso molecolare:590.16Muscarine tosylate
CAS:Muscarine ((+)-Muscarine) tosylate, a prototype mAChR agonist, serves as a parasympathetic nervous system stimulant and is recognized for its toxic properties [1] [2].Formula:C16H27NO5SColore e forma:SolidPeso molecolare:345.45Hydroxy Varenicline
CAS:Hydroxy varenicline, a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline, functions within the biochemical pathway by interacting with nAChR sites.Formula:C13H13N3OColore e forma:SolidPeso molecolare:227.267VU 0255035
CAS:<p>VU 0255035 is a highly selective, competitive and brain penetrant muscarinic M1 receptor antagonist with an IC50 of 130 nM.</p>Formula:C18H20N6O3S2Purezza:98.09% - 98.1%Colore e forma:SolidPeso molecolare:432.52Cynandione A
CAS:Cynandione A is an acetophenone derived from Cynanchum wilfordii with anti-inflammatory activity.Formula:C16H14O6Purezza:99.62%Colore e forma:SolidPeso molecolare:302.28VU0453595
CAS:<p>VU0453595 is a M1 positive allosteric modulator (PAM).</p>Formula:C18H15FN4OPurezza:99.91%Colore e forma:SolidPeso molecolare:322.34UFP-512
CAS:UFP-512 is a selective delta-opioid (DOP) receptor agonist.Formula:C31H33N5O5Purezza:98%Colore e forma:SolidPeso molecolare:555.62A-424274
CAS:A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.Formula:C14H15N3Purezza:98%Colore e forma:SolidPeso molecolare:225.29L 687306
CAS:L 687306 is a partial agonist of muscarinic M1 receptors. It is also a highly competitive antagonist at cardiac M2 receptors and ileal M3 muscarinic receptors.Formula:C11H15N3OColore e forma:SolidPeso molecolare:205.26ABT-418 hydrochloride
CAS:ABT-418 HCl enhances cognition and reduces anxiety as a selective nAChRs agonist, researched for Alzheimer's.Formula:C9H15ClN2OColore e forma:SolidPeso molecolare:202.68BMS-933043
CAS:BMS-933043: α7 nAChR partial agonist, binds rat (Ki=3.3 nM) & human (Ki=8.1 nM), agonist with EC50=23.4 nM (calcium assay), 0.14-0.29 μM (electrophysiology).Formula:C16H19N7OPurezza:98%Colore e forma:SolidPeso molecolare:325.37PTAC oxalate
CAS:muscarinic receptor ligandFormula:C14H21N3O4S2Purezza:98%Colore e forma:SolidPeso molecolare:359.46Timepidium bromide
CAS:Timepidium bromide is an agent of anticholinergic.Formula:C17H22BrNOS2Purezza:98%Colore e forma:SolidPeso molecolare:400.4LG 50643
CAS:LG 50643 is a muscarinic antagonist.Formula:C24H34INO2Purezza:98%Colore e forma:SolidPeso molecolare:495.44Zamifenacin fumarate
CAS:Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.Formula:C31H33NO7Purezza:99.88%Colore e forma:SolidPeso molecolare:531.6LY2033298
CAS:LY2033298 enhances oximoline's effect on hamster circadian rhythms, aiding neurosystem disorders.Formula:C13H14ClN3O2SPurezza:98.78%Colore e forma:SolidPeso molecolare:311.79Tematropium
CAS:Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.Formula:C21H31NO8SPurezza:99.89%Colore e forma:SolidPeso molecolare:457.54VU6007496
CAS:<p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>Formula:C25H27N5O2Colore e forma:SolidPeso molecolare:429.51p-F-HHSiD hydrochloride
CAS:p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3mAChR antagonist. It is capable of inhibiting acetylcholine-mediated vasodilation in human umbilical vein endothelial cells (HUVEC).Formula:C20H33ClFNOSiPeso molecolare:386.019Lu 26-046
CAS:Lu 26-046 is a muscarinic receptor agonist.Formula:C10H12N2OSColore e forma:SolidPeso molecolare:208.28YM-49598 iodide
CAS:YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.Formula:C36H45Cl2IN2O2Colore e forma:SolidPeso molecolare:735.57CHF-6366
CAS:CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.Formula:C42H48N6O8Colore e forma:SolidPeso molecolare:764.87VU6016235
CAS:VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.Formula:C21H22N4OSColore e forma:SolidPeso molecolare:378.49TAAR1 agonist 2
CAS:TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.Formula:C9H11NOColore e forma:SolidPeso molecolare:149.19(S)-Albuterol
CAS:<p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>Formula:C13H21NO3Colore e forma:SolidPeso molecolare:239.311TDI-11861
CAS:TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.Formula:C22H25ClF2N6O3Colore e forma:SolidPeso molecolare:494.92
