AChR
Gli inibitori del recettore dell'acetilcolina (AChR) sono composti che bloccano l'attività dei recettori dell'acetilcolina, fondamentali per la neurotrasmissione nei sistemi nervoso centrale e periferico. Gli AChR svolgono un ruolo cruciale nella contrazione muscolare, nella memoria e nelle funzioni cognitive. Gli inibitori degli AChR vengono utilizzati per studiare condizioni come la miastenia grave, l'Alzheimer e altri disturbi neurologici. Modulando l'attività degli AChR, questi inibitori possono aiutare a svelare le complessità della segnalazione colinergica nel cervello. Presso CymitQuimica, offriamo una gamma di inibitori degli AChR per supportare la tua ricerca in neuroscienze, farmacologia e malattie neurodegenerative.
Trovati 617 prodotti di "AChR"
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Hydroxybupropion
CAS:Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).Formula:C13H18ClNO2Purezza:99.73%Colore e forma:Off-White SolidPeso molecolare:255.74DSPE-PEG2000-RVG29
<p>DSPE-PEG2000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and can traverse the BBB.</p>Colore e forma:Odour SolidNNC 11-1607
CAS:NNC 11-1607 is a functionally selective agonist of M(1)/M(4) mAChR.Formula:C30H32N6O2S2Colore e forma:SolidPeso molecolare:572.74Ebiratide TFA
<p>Ebiratide (HOE-427) TFA is a derivative of ACTH4-9 that exerts its effect directly on the central nervous system, enhancing memory. Ebiratide TFA also promotes the metabolism of acetylcholine (ACh) in the rat brain.</p>Formula:C48H73N11O10S·xC2HF3O2Colore e forma:SolidPeso molecolare:996.23 (free base)RuBi-Nicotine
CAS:Nicotinic receptor agonistFormula:C40H44Cl2N8RuPurezza:98%Colore e forma:SolidPeso molecolare:808.81PF-06827443
PF-06827443 is a orally bioavailable, CNS-penetrant M1-selective PAM with minimal agonist activity.Formula:C24H24N2O4Colore e forma:SolidPeso molecolare:404.47Lobeline sulfate
CAS:Lobeline sulfate, an alkaloid like nicotine, aids in smoking cessation, insomnia, and respiratory issues. Less potent on nicotinic receptors.Formula:C22H29NO6SPurezza:98%Colore e forma:White PowderPeso molecolare:435.54(Rac)-5-Carboxy tolterodine
CAS:<p>(Rac)-5-Carboxy tolterodine is an inactive metabolite of Tolterodine, which acts as a muscarinic acetylcholine receptor antagonist.</p>Formula:C22H29NO3Colore e forma:SolidPeso molecolare:355.47Tiquizium
CAS:<p>Tiquizium has effective Antimuscarinic effect, and causes significant bronchodilation in patients with chronic obstructive pulmonary disease.</p>Formula:C19H24NS2Purezza:99.82%Colore e forma:SolidPeso molecolare:330.53Lu AE51090
CAS:Lu AE51090 is a selective muscarinic M1 receptor agonist with minimal off-target effects, receptor function and selective pharmacological modulation.Formula:C24H29N3O3Purezza:99.57%Colore e forma:SolidPeso molecolare:407.51Angiopeptin
CAS:<p>Angiopeptin is a synthetic octapeptide analog of somatostatin; suppresses accelerated transplant atherosclerosis in rabbit heart arteries.</p>Formula:C54H71N11O10S2Colore e forma:SolidPeso molecolare:1098.34R-(+)-Cotinine
CAS:<p>R-(+)-Cotinine, an inactive nicotine metabolite, boosts Ach-induced current in human α7 nAChRs.</p>Formula:C10H12N2OColore e forma:SolidPeso molecolare:176.22Bensultap
CAS:Bensultap is an agricultural chemical typically used as a pesticide.Formula:C17H21NO4S4Purezza:98%Colore e forma:SolidPeso molecolare:431.61Perindoprilat
CAS:Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.Formula:C17H28N2O5Purezza:99.48%Colore e forma:SolidPeso molecolare:340.41Aceclidine (hydrochloride)
CAS:agonist of muscarinic receptorsFormula:C9H16ClNO2Purezza:98%Colore e forma:SolidPeso molecolare:205.68α-Conotoxin PIA
CAS:Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nMFormula:C79H125N27O25S4Purezza:98%Colore e forma:SolidPeso molecolare:1981.3G-Protein antagonist peptide
CAS:Peptide inhibits G protein-receptor binding; competitively blocks M2 and β-adrenoceptor-induced Gs/Gi/Go activation.Formula:C57H64N12O9SPurezza:98%Colore e forma:SolidPeso molecolare:1093.27α-Muricholic acid
CAS:α-Muricholic acid is the most abundant primary bile acid in rodents.Formula:C24H40O5Purezza:98%Colore e forma:SolidPeso molecolare:408.57GeX-2
CAS:<p>GeX-2 is a truncated analogue of αO-conotoxin. It has the ability to activate GABAB receptors and inhibit α9α10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury.</p>Formula:C103H169N43O27Colore e forma:SolidPeso molecolare:2441.72TDI-10229
CAS:<p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>Formula:C16H16ClN5Purezza:99.85% - 99.89%Colore e forma:SoildPeso molecolare:313.78Soclenicant
CAS:Soclenicant is a negative-altering modulator of α 7 -nAChR for anxiety, depression, and PTSD, due to its high selectivity, oral availabilityFormula:C24H26N4O3Purezza:99.57%Colore e forma:SoildPeso molecolare:418.49M3/PDE4 modulator-1
M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.Formula:C38H41Cl2N3O8SColore e forma:SolidPeso molecolare:770.72α-Conotoxin EI
CAS:Selective antagonist of neuromuscular nicotinic receptors α1β1γδFormula:C83H125N27O27S5Purezza:98%Colore e forma:SolidPeso molecolare:2093.37Methylatropine (nitrate)
CAS:Methylatropine: Muscarinic antagonist, <0.1 nM IC50, atropine derivative, lowers ACh's effect on BP, affects salivation, pupil dilation, heart rate.Formula:C18H26N2O6Colore e forma:SolidPeso molecolare:366.414M 8218
CAS:M 8218 is a bioactive chemical.Formula:C20H29NO2Colore e forma:SolidPeso molecolare:315.45BTMPS
CAS:<p>BTMPS is a usage-dependent nicotinic antagonist capable of reducing acute withdrawal symptoms associated with morphine use.</p>Formula:C28H52N2O4Purezza:98.1%Colore e forma:SolidPeso molecolare:480.72Thiothixene
CAS:Thiothixene has a wide range of applications in life science related research.Formula:C23H29N3O2S2Colore e forma:SolidPeso molecolare:443.62LAS190792
CAS:LAS190792 (AZD8999) is a dual muscarinic antagonist/β2-agonist, pIC50s (M1-M5, β1-β3): 8.9-5.6; used as a bronchodilator.Formula:C39H43ClN4O9S2Colore e forma:SolidPeso molecolare:811.36Emraclidine
CAS:Emraclidine (CVL-231) is a novel, highly selective allosteric modulator of the muscarinic M4 receptor positive receptor.Cost-effective and quality-assured.Formula:C20H21F3N4OPurezza:99.96%Colore e forma:SolidPeso molecolare:390.4nAChR modulator-1
CAS:nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .Formula:C12H8ClN3O2Colore e forma:SolidPeso molecolare:261.66Biperiden Hydrochloride
CAS:<p>Biperiden HCl is an anti-Parkinson's drug, blocks M1 receptors, manages all Parkinson's types, and is FDA-approved. Non-toxic at 0.11 mg/kg to rats' cognition.</p>Formula:C21H30ClNOPurezza:98%Colore e forma:SolidPeso molecolare:347.92Epiboxidine hydrochloride
CAS:Epiboxidine HCl: potent α4β2 nAChR agonist; Ki 0.46 nM (rat), 1.2 nM (human); Epibatidine analog.Formula:C10H15ClN2OColore e forma:SolidPeso molecolare:214.69LtIA-F
LtIA-F, a fluorescent LtIA derivative, aids study of α3β2 nAChR's structure, distribution, and binding domain.Formula:C86H121N25O22S4Colore e forma:SolidPeso molecolare:1985.31ANQ-9040
CAS:<p>ANQ-9040 is a nondepolarizing neuromuscular relaxant of the steroid class.</p>Formula:C36H58N2O5SColore e forma:SolidPeso molecolare:630.92(S)-Dinotefuran
CAS:(S)-Dinotefuran, a neonicotinoid, more toxic to bees than its R-isomer, targets α8 nAChR.Formula:C7H14N4O3Colore e forma:SolidPeso molecolare:202.21(rel)-Asperparaline A
CAS:<p>Aspergillimide, from A. japonicus, inhibits silkworm neuron nAChRs (IC50s: 20.2/39.6 nM), not affecting chicken nAChRs, and paralyzes silkworm larvae.</p>Formula:C20H29N3O3Colore e forma:SolidPeso molecolare:359.47(±)-Coniine
CAS:(±)-Coniine, a piperidine alkaloid, is a toxin found in poison hemlock.Formula:C8H17NColore e forma:SolidPeso molecolare:127.23α-Conotoxin PIA TFA
α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist.Formula:C81H126F3N27O27S4Purezza:98.81%Colore e forma:SolidPeso molecolare:2095.3(Rac)-Sabcomeline
CAS:(Rac)-Sabcomeline ((Rac)-SB-202026) is an M1/M4 muscarinic agonist used in the study of neurologic disorders such as schizophrenia.Formula:C10H15N3OPurezza:99.14%Colore e forma:SolidPeso molecolare:193.25NSC 23766
CAS:NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.Formula:C24H35N7Purezza:99.49%Colore e forma:SolidPeso molecolare:421.58Tolterodine
CAS:Tolterodine ((R)-(+)-Tolterodine) is an mACh antagonist used in the treatment of detrusor instability and overactive bladder syndrome.Formula:C22H31NOPurezza:99.71%Colore e forma:White Like Or Light Brown Crystalline PowderPeso molecolare:325.49Metixene hydrochloride hydrate
CAS:Metixene HCl hydrate is a potential anticholinergic for Parkinson's with IC50 of 55 nM and Ki of 15 nM against muscarine receptors.Formula:C20H26ClNOSPurezza:99.99%Colore e forma:SolidPeso molecolare:363.95NKH477
CAS:NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity.Formula:C27H44ClNO8Purezza:98% - 98%Colore e forma:SolidPeso molecolare:546.09Fipexide hydrochloride
CAS:Fipexide (hydrochloride) is a kind of psychoactive drug of the piperazine class.Formula:C20H22Cl2N2O4Colore e forma:SolidPeso molecolare:425.31YM-58790 hydrochloride
CAS:YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).Formula:C27H32ClN3O2Purezza:98%Colore e forma:SolidPeso molecolare:466.02Palmatine hydroxide
CAS:<p>Palmatine hydroxide: oral IDO-1 inhibitor (IC50: 3-157μM), targets WNV protease, has anti-cancer/viral and neuroprotective properties.</p>Formula:C21H23NO5Colore e forma:SolidPeso molecolare:369.41Cevimeline
CAS:Cevimeline: muscarinic agonist, treats dry mouth & Sjögren's, boosts saliva post-cancer radiotherapy.Formula:C10H17NOSColore e forma:Off-White SolidPeso molecolare:199.31ABT-107
CAS:ABT-107: α7 neuronal receptor agonist; protects rats' brains from 6-OHDA-induced damage.Formula:C19H20N4OColore e forma:SolidPeso molecolare:320.396Dexetimide
CAS:Dexetimide, a muscarinic receptor antagonist, treats neuroleptic-induced parkinsonism.Formula:C23H26N2O2Colore e forma:SolidPeso molecolare:362.46β2AR/M-receptor agonist-2
CAS:<p>β2AR/M-receptor agonist-2 is a dual-function compound acting as a muscarinic antagonist and β2 adrenoceptor agonist (MABA).</p>Formula:C36H49ClN4O7SColore e forma:SolidPeso molecolare:717.31
