p97
Gli inibitori di p97 sono composti che inibiscono p97, noto anche come Proteina Contenente Valosina (VCP), un'ATPasi coinvolta in vari processi cellulari, inclusa la degradazione delle proteine, la regolazione del ciclo cellulare e la riparazione del DNA. p97 è un attore chiave nel sistema ubiquitina-proteasoma e la sua inibizione è di grande interesse nella ricerca sul cancro, nelle malattie neurodegenerative e in altri disturbi in cui è alterata l'omeostasi proteica. Presso CymitQuimica, offriamo inibitori di p97 per supportare la tua ricerca sulla proteostasi, neurobiologia e terapia del cancro.
Trovati 15 prodotti di "p97"
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UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C23H16ClN3O3SColore e forma:SolidPeso molecolare:449.91UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formula:C20H15ClN2O5SColore e forma:SolidPeso molecolare:430.86UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C17H17ClN4O2Colore e forma:SolidPeso molecolare:344.8MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formula:C29H29F3N2Colore e forma:SolidPeso molecolare:462.55CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Formula:C24H23N5O2Purezza:95.95% - 99.92%Colore e forma:SolidPeso molecolare:413.47ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formula:C23H25ClN4OPurezza:99.91% - 99.96%Colore e forma:SolidPeso molecolare:408.92ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Formula:C23H24N4OPurezza:98%Colore e forma:SolidPeso molecolare:372.46ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Formula:C23H20N6OPurezza:99.73% - >99.99%Colore e forma:SolidPeso molecolare:396.44NMS-873
CAS:<p>NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.</p>Formula:C27H28N4O3S2Purezza:99.05% - 99.85%Colore e forma:SolidPeso molecolare:520.67DBEQ
CAS:<p>DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.</p>Formula:C22H20N4Purezza:98.93% - ≥95%Colore e forma:SolidPeso molecolare:340.42NPD8733
CAS:<p>NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.</p>Formula:C18H15NO4Purezza:98.48%Colore e forma:SolidPeso molecolare:309.32CB-5339
CAS:<p>p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].</p>Formula:C24H24N6OPurezza:97.66%Colore e forma:SoildPeso molecolare:412.49UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formula:C30H32F2N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:594.68VCP/p97 IN-2
CAS:VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Formula:C24H23N5O2Colore e forma:SolidPeso molecolare:413.47p97-IN-1
CAS:p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Formula:C25H26N6O2Colore e forma:SolidPeso molecolare:442.51
