Cisteina proteasi
Gli inibitori delle proteasi a cisteina sono composti che mirano e inibiscono le proteasi a cisteina, una classe di enzimi che degradano le proteine rompendo i legami peptidici in cui un residuo di cisteina agisce come nucleofilo. Questi enzimi sono coinvolti in vari processi fisiologici, tra cui l'apoptosi, la risposta immunitaria e il turnover proteico. Gli inibitori delle proteasi a cisteina sono cruciali per lo studio di malattie come il cancro, i disturbi neurodegenerativi e le infezioni parassitarie. Presso CymitQuimica, offriamo inibitori delle proteasi a cisteina per supportare la tua ricerca in proteolisi, regolazione cellulare e scoperta di farmaci.
Trovati 110 prodotti di "Cisteina proteasi"
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PMSF
CAS:PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine/cysteine protease , preparation of cell lysates. High-Quality, Low-Cost!Formula:C7H7FO2SPurezza:97.75% - 99.88%Colore e forma:White To Cream SolidPeso molecolare:174.19N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formula:C35H37F3N6O8Purezza:99.88%Colore e forma:SolidPeso molecolare:726.7Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidRef: TM-L1100
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaCathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormula:C24H35N5O4·xC2HF3O2Colore e forma:SolidLeupeptin
CAS:Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.Formula:C20H38N6O4Purezza:98%Colore e forma:SolidPeso molecolare:426.5626,6′-Dihydroxythiobinupharidine
CAS:6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormula:C30H42N2O4SColore e forma:SolidPeso molecolare:526.73VK13
VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.Formula:C24H28N4O5Colore e forma:SolidPeso molecolare:452.503Z-Phe-Tyr(tBu)-diazomethylketone
CAS:Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.Formula:C31H34N4O5Colore e forma:SolidPeso molecolare:542.636Z-L(D-Val)G-CHN2
Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.Formula:C22H31N5O5Purezza:98%Colore e forma:SolidPeso molecolare:445.51Relacatib
CAS:Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Formula:C27H32N4O6SColore e forma:SolidPeso molecolare:540.64FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.
Formula:C48H58BF2N7O5Colore e forma:SolidPeso molecolare:861.45605N-CBZ-Phe-Arg-AMC
CAS:Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formula:C33H36N6O6Purezza:98%Colore e forma:White To Off-White PowderPeso molecolare:612.68Hepcidin-1 (mouse)
CAS:Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.Formula:C111H169N31O35S8Colore e forma:SolidPeso molecolare:2754.24Z-FG-NHO-Bz
CAS:Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Formula:C26H25N3O6Colore e forma:SolidPeso molecolare:475.49Cathepsin D and E FRET Substrate
CAS:Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Formula:C85H122N22O19Colore e forma:SolidPeso molecolare:1756.046Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.Colore e forma:Odour SolidZ-Arg-Arg-βNA acetate
CAS:Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.Formula:C32H43N9O6Colore e forma:SolidPeso molecolare:649.74Gallinamide A TFA
CAS:Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].Formula:C33H53F3N4O9Colore e forma:SolidPeso molecolare:706.79Z-Leu-Tyr-Chloromethylketone
CAS:Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].Formula:C24H29ClN2O5Colore e forma:SolidPeso molecolare:460.95Cathepsin L-IN-3
CAS:Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.Formula:C41H49N7O4SColore e forma:SolidPeso molecolare:735.94Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Colore e forma:Odour SolidCathepsin Inhibitor 4
Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.
Formula:C24H35N3O5Peso molecolare:445.25767Mpro/Cathepsin L-IN-1
Mpro/Cathepsin L-IN-1 (Compound 4d) is an inhibitor of SARS-CoV-2 Mpro and hCatL, with Ki values of 5.54 μM and 0.701 μM, respectively.Formula:C24H32FN3O4Peso molecolare:445.23768Ac-PLVE-FMK
CAS:Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl fluoromethylketone (FMKs), serves as a cathepsin inhibitor. It is utilized in cancer research [1].Formula:C25H41FN4O7Purezza:98%Colore e forma:SolidPeso molecolare:528.61Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formula:C21H18FN3O4Purezza:99.11%Colore e forma:SolidPeso molecolare:395.38Ref: TM-T9710
1mg96,00€5mg202,00€10mg305,00€25mg550,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)224,00€Tacalcitol monohydrate
CAS:Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.Formula:C27H46O4Purezza:99.284%Colore e forma:SolidPeso molecolare:434.65Mpro/Cathepsin L-IN-2
Mpro/Cathepsin L-IN-2 (Compound 1) is an irreversible dual inhibitor targeting the main protease of SARS-CoV-2 (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64). Mpro/Cathepsin L-IN-2 shows potential for use in research related to COVID-19 and other coronavirus infections.Colore e forma:Odour SolidCathepsin D and E FRET Substrate acetate
Fluorogenic substrate for cathepsins D & E, not B/H/L; useful in their mechanistic studies.Formula:C86H124N22O21Purezza:95.63%Colore e forma:SolidPeso molecolare:1802.04PD150606
CAS:PD150606 is a calpain inhibitor with neuroprotective activity that inhibits μ-calpains and interferes with excitotoxicity-dependent motor neuron death.Formula:C9H7IO2SPurezza:98.19%Colore e forma:SolidPeso molecolare:306.12LN5P45
LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis [1Formula:C13H15ClN2O2Colore e forma:SolidPeso molecolare:266.72JTE-607
CAS:JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.Formula:C25H33Cl4N3O5Purezza:97.88%Colore e forma:SolidPeso molecolare:597.36Ref: TM-T27695
1mg44,00€5mg87,00€10mg159,00€25mg328,00€50mg518,00€100mg747,00€200mg1.026,00€1mL*10mM (DMSO)115,00€E 64c
CAS:E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.Formula:C15H26N2O5Purezza:98.73%Colore e forma:SolidPeso molecolare:314.382-Cyanopyrimidine
CAS:2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)Formula:C5H3N3Purezza:99.27%Colore e forma:Crystalline SolidPeso molecolare:105.1Odanacatib
CAS:Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.Formula:C25H27F4N3O3SPurezza:98.53% - 99.53%Colore e forma:SolidPeso molecolare:525.56Ref: TM-T6035
2mg35,00€5mg52,00€10mg80,00€25mg120,00€50mg188,00€100mg354,00€200mgPrezzo su richiesta1mL*10mM (DMSO)60,00€L-006235
CAS:L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.Formula:C24H30N6O2SPurezza:99.37%Colore e forma:SolidPeso molecolare:466.6Ref: TM-T21616
2mg42,00€5mg64,00€10mg97,00€25mg187,00€50mg316,00€100mg455,00€200mg635,00€1mL*10mM (DMSO)65,00€MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Formula:C22H26N2O4Purezza:95.06%Colore e forma:SolidPeso molecolare:382.45Ref: TM-T2470
1mg35,00€2mg52,00€5mg74,00€10mg96,00€25mg135,00€50mg177,00€100mg299,00€1mL*10mM (DMSO)80,00€Aloxistatin
CAS:Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.Formula:C17H30N2O5Purezza:99.46% - 99.69%Colore e forma:SolidPeso molecolare:342.43Ref: TM-T6040
1mg43,00€2mg56,00€5mg88,00€10mg119,00€25mg188,00€50mg311,00€100mg502,00€500mg1.130,00€1mL*10mM (DMSO)70,00€Balicatib
CAS:Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.Formula:C23H33N5O2Purezza:97.78% - 98.17%Colore e forma:White To Off-White Solid PowderPeso molecolare:411.54Ref: TM-T1850
2mg42,00€5mg62,00€10mg99,00€25mg224,00€50mg378,00€100mg605,00€200mg848,00€1mL*10mM (DMSO)67,00€KGP94
CAS:KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.Formula:C14H12BrN3OSPurezza:99.6%Colore e forma:SolidPeso molecolare:350.23Ref: TM-T27730
1mg65,00€5mg138,00€10mg215,00€25mg359,00€50mg510,00€100mg692,00€200mg928,00€1mL*10mM (DMSO)152,00€LY 3000328
CAS:LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.Formula:C25H29FN4O5Purezza:97.83% - 99.54%Colore e forma:SolidPeso molecolare:484.52Ref: TM-TQ0116
1mg90,00€2mg130,00€5mg198,00€10mg263,00€25mg462,00€50mg672,00€100mg945,00€1mL*10mM (DMSO)207,00€CA-074 methyl ester
CAS:CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). neuroprotective effect. High-Quality, Low-Cost!Formula:C19H31N3O6Purezza:97.26% - 99.58%Colore e forma:SolidPeso molecolare:397.47(1S,2R)-Alicapistat
CAS:(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.Formula:C25H27N3O4Purezza:99.60%Colore e forma:SoildPeso molecolare:433.5Ref: TM-T60150
1mg67,00€5mg150,00€10mg208,00€25mg316,00€50mg423,00€100mg567,00€1mL*10mM (DMSO)170,00€S 2160
CAS:S 2160 is a synthetic chromogenic substrate for thrombin.Formula:C33H40N8O6Colore e forma:SolidPeso molecolare:644.72Cathepsin Inhibitor 1
CAS:Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
Formula:C20H24ClN5O2Purezza:99.78%Colore e forma:SolidPeso molecolare:401.89DTS
CAS:DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential.Formula:C14H14S3Purezza:98%Colore e forma:SolidPeso molecolare:278.46JPM-OEt
CAS:JPM-OEt: broad-spectrum, covalent cysteine cathepsin inhibitor with antitumor effects.Formula:C20H28N2O6Purezza:98%Colore e forma:SolidPeso molecolare:392.45Calpain-2-IN-1
CAS:Calpain-2-IN-1 is a selective calpain-2 inhibitor with Ki values of 181 nM for calpain-1 and 7.8 nM for calpain-2, applicable for neurodegenerative diseases a.Formula:C28H37N3O7Colore e forma:SolidPeso molecolare:527.61MDL 27399
CAS:MDL 27399 suppresses human neutrophil cathepsin G.Formula:C26H36N4O8Colore e forma:SolidPeso molecolare:532.59AM 4299 B
CAS:AM 4299 B is a novel inhibitor of a thiol protease.Formula:C16H27N3O7Purezza:98%Colore e forma:SolidPeso molecolare:373.4GSK-2793660
CAS:GSK-2793660, an oral, irreversible CTSC inhibitor, aids bronchiectasis research.Formula:C20H27N3O3Purezza:98%Colore e forma:SolidPeso molecolare:357.45Cysteine Protease inhibitor hydrochloride
CAS:Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.Formula:C18H15ClN4OPurezza:98%Colore e forma:SolidPeso molecolare:338.79Gü1303
CAS:Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK).Formula:C20H22N4O3Colore e forma:SolidPeso molecolare:366.41NAAA-IN-2
CAS:NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.
Formula:C11H13N3O2SColore e forma:SolidPeso molecolare:251.3SSAA09E1
CAS:SSAA09E1 blocks SARS-CoV entry, lowers ACE2-mediated HEK293T cell infection (EC50 = 6.7 μM), and inhibits cathepsin L (IC50 = 5.33 μM).Formula:C7H9N3S2Colore e forma:SolidPeso molecolare:199.3VEL-0230
CAS:VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.Formula:C14H24NNaO5Colore e forma:SolidPeso molecolare:309.33SQ 32602
CAS:SQ 32602 is a cathepsin E inhibitor.Formula:C32H52N3O7PColore e forma:SolidPeso molecolare:621.74GSK2793660 free base
CAS:GSK-2793660, a cathepsin C inhibitor, may treat cystic fibrosis and related lung conditions.Formula:C22H31N3O3Colore e forma:SolidPeso molecolare:385.5ASPER-29
CAS:ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.Formula:C31H29BrN2O5SColore e forma:SolidPeso molecolare:621.54Dutacatib
CAS:Dutacatib is an inhibitor of SARS-CoV-2 3CLpro and cathepsin K, offering antiviral properties and potential benefits in treating cancer-induced bone disease.
Formula:C23H31N7OColore e forma:SolidPeso molecolare:421.54JNJ-10329670
CAS:JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.Formula:C30H34ClF3N6O3SColore e forma:SolidPeso molecolare:651.14Gü2602
CAS:Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for matureFormula:C16H22N4O3Colore e forma:SolidPeso molecolare:318.37L-873724
CAS:L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.Formula:C23H26F3N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:481.53CAA0225
CAS:CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.Formula:C28H29N3O5Colore e forma:SolidPeso molecolare:487.55GSK2793660 HCl
CAS:GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.Formula:C22H32ClN3O3Colore e forma:SolidPeso molecolare:421.96Cysteine protease inhibitor-2
CAS:Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.Formula:C13H5N5OPurezza:98%Colore e forma:SolidPeso molecolare:247.21Calpain Inhibitor XII
CAS:Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a calpain I inhibitor that inhibits calpain II and cathepsin B.
Formula:C26H34N4O5Colore e forma:SolidPeso molecolare:482.57Cysteine Protease inhibitor
CAS:Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine ProteaseFormula:C18H14N4OPurezza:98%Colore e forma:SolidPeso molecolare:302.33Kgp-IN-1
CAS:Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.Formula:C19H24F4N4O3Purezza:98%Colore e forma:SolidPeso molecolare:432.41LHVS
CAS:LHVS effectively blocks T.
Formula:C28H37N3O5SPurezza:98%Colore e forma:SolidPeso molecolare:527.68CA 074
CAS:CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates
Formula:C18H29N3O6Purezza:97.80%Colore e forma:SolidPeso molecolare:383.44Oxocarbazate
CAS:Oxocarbazate (CID23631927) is a subnanomolar, reversible cathepsin L inhibitor, also reducing SARS-CoV and Ebola virus entry into human cells.Formula:C28H33N5O6Colore e forma:SolidPeso molecolare:535.59LmCPB-IN-1
CAS:LmCPB-IN-1, compound 35, is a reversible inhibitor of LmCPB with strong binding (pKi 9.7).Formula:C18H30N6O2Colore e forma:SolidPeso molecolare:362.47Cathepsin L/S-IN-1
Cathepsin L/S-IN-1 inhibits Cathepsin L & S (IC50: 4.10 & 1.79 μM) and reduces metastasis in pancreatic cancer cells.Formula:C29H33BrN4O4SColore e forma:SolidPeso molecolare:613.57Cathepsin X-IN-1
CAS:Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].
Formula:C15H13N3O3SPurezza:99.34%Colore e forma:SolidPeso molecolare:315.35JNJ-10311795
CAS:JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.Formula:C40H35N2O6PPurezza:97.43%Colore e forma:SolidPeso molecolare:670.69Z-LVG
CAS:Z-LVG, an irreversible cysteine protease inhibitor and a tripeptide derivative of cystatin C, serves as an inhibitor of viral replication and is utilized inFormula:C21H31N3O6Colore e forma:SolidPeso molecolare:421.49Cathepsin K inhibitor 3
CAS:Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.Formula:C30H31FN4O4SColore e forma:SolidPeso molecolare:562.65Cathepsin Inhibitor 2
CAS:Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).Formula:C19H21F6N3OPurezza:98%Colore e forma:SolidPeso molecolare:421.38Z-FG-NHO-BzOME
CAS:Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,Formula:C27H27N3O7Colore e forma:SolidPeso molecolare:505.52Z-DEVD-CMK
CAS:Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].Formula:C27H35ClN4O12Colore e forma:SolidPeso molecolare:643.04MeOSuc-AAPV-CMK
CAS:MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediatedFormula:C22H35ClN4O7Colore e forma:SolidPeso molecolare:502.99SPR38
SPR38: SARS-CoV-2 protease inhibitor with Ki 0.260 μM; also blocks hCatL (Ki 1.92 μM) and hCatB (Ki 11.1 μM).Formula:C24H33N3O5Colore e forma:SolidPeso molecolare:443.54(Rac)-Neurodegenerative Disorder-Targeting Compound 1
CAS:(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor.Formula:C28H28N4O4Colore e forma:SolidPeso molecolare:484.55Petesicatib
CAS:Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.Formula:C25H23F6N5O4SPurezza:99.76%Colore e forma:SolidPeso molecolare:603.54Ref: TM-T16474
1mg105,00€5mg250,00€10mg393,00€25mg777,00€50mg1.198,00€100mg1.549,00€200mg2.080,00€1mL*10mM (DMSO)331,00€SQ 32056
CAS:SQ 32056 is a cathepsin E inhibitor.Formula:C37H56N4O5Purezza:98%Colore e forma:SolidPeso molecolare:636.86MPI8
CAS:MPI8 is a SARS-CoV-2 Protease inhibitor (IC50 = 105 nM).Formula:C32H48N4O7Colore e forma:SolidPeso molecolare:600.75ABP 25
CAS:ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.Formula:C55H66ClN5O3Colore e forma:SolidPeso molecolare:880.6SID 26681509
CAS:SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).Formula:C27H33N5O5SPurezza:99.18%Colore e forma:SolidPeso molecolare:539.65Ref: TM-T12909
1mg63,00€5mg137,00€10mg205,00€25mg414,00€50mg618,00€100mg882,00€1mL*10mM (DMSO)163,00€MK-0674
CAS:MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.Formula:C26H27F6N3O2Purezza:97.3% - 99.91%Colore e forma:SolidPeso molecolare:527.5VBY-825
CAS:VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.Formula:C23H29F4N3O5SPurezza:99.91%Colore e forma:SolidPeso molecolare:535.55SID 26681509 quarterhydrate
SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).Formula:C27H35N5O6SColore e forma:SolidPeso molecolare:544.16RO5461111
CAS:RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Formula:C27H24F6N4O4SColore e forma:SolidPeso molecolare:614.56Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Formula:C28H21F3N6OSColore e forma:SolidPeso molecolare:546.57BI-1915
CAS:BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.
Formula:C21H37N5O3Colore e forma:SolidPeso molecolare:407.55Cathepsin K inhibitor 2
CAS:Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Formula:C30H33F4N5O3Colore e forma:SolidPeso molecolare:587.61ONO-5334
CAS:ONO-5334: selective cathepsin K inhibitor, potential for osteoporosis study; Ki: 0.10 nM (human), 0.049 nM (rabbit), 0.85 nM (rat).Formula:C21H34N4O4SPurezza:98.22% - 99.60%Colore e forma:SolidPeso molecolare:438.58Cathepsin C-IN-4
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).Formula:C21H14ClF3N4SColore e forma:SolidPeso molecolare:446.88AEP-IN-1
APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.Formula:C18H27N3O3Colore e forma:SolidPeso molecolare:333.43CTSL/CAPN1-IN-2
CAS:CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].Formula:C34H40N4O6Colore e forma:SolidPeso molecolare:600.7SAR-114137
CAS:SAR-114137 is a histone sphingomyelin kinase inhibitor used in the study of molluscum arteriosum and peripheral neuropathic pain.Formula:C25H34N4O7SPurezza:99.09% - 99.91%Colore e forma:SolidPeso molecolare:534.63CatD-IN-1
CAS:CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Formula:C18H18Cl2N4O5Colore e forma:SolidPeso molecolare:441.265GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Formula:C33H39N3O6Colore e forma:SolidPeso molecolare:573.68Verducatib
CAS:Verducatib is an inhibitor of cathepsins (cathepsin).Formula:C31H35FN4O3Colore e forma:SolidPeso molecolare:530.633Z-FY-CHO
CAS:Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.Formula:C26H26N2O5Purezza:95.88%Colore e forma:SolidPeso molecolare:446.5Cathepsin C-IN-5
CAS:Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.
Formula:C21H17ClN6OSColore e forma:SolidPeso molecolare:436.92Dual Cathepsin L/JAK-IN-1
CAS:DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).Formula:C19H18ClN5Colore e forma:SolidPeso molecolare:351.833Z-Val-Val-Nle-diazomethylketone
CAS:Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.Formula:C25H37N5O5Colore e forma:SolidPeso molecolare:487.59MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Formula:C17H24F3N3O4Purezza:99.27%Colore e forma:SolidPeso molecolare:391.39PD 151746
CAS:PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Formula:C11H8FNO2SPurezza:98.63% - ≥95%Colore e forma:SolidPeso molecolare:237.25ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formula:C19H35N3O4SPurezza:98%Colore e forma:White PowderPeso molecolare:401.56
