Cisteina proteasi
Gli inibitori delle proteasi a cisteina sono composti che mirano e inibiscono le proteasi a cisteina, una classe di enzimi che degradano le proteine rompendo i legami peptidici in cui un residuo di cisteina agisce come nucleofilo. Questi enzimi sono coinvolti in vari processi fisiologici, tra cui l'apoptosi, la risposta immunitaria e il turnover proteico. Gli inibitori delle proteasi a cisteina sono cruciali per lo studio di malattie come il cancro, i disturbi neurodegenerativi e le infezioni parassitarie. Presso CymitQuimica, offriamo inibitori delle proteasi a cisteina per supportare la tua ricerca in proteolisi, regolazione cellulare e scoperta di farmaci.
Trovati 135 prodotti per "Cisteina proteasi".
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FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.Formula:C48H58BF2N7O5Colore e forma:SolidPeso molecolare:861.45605Z-Leu-Tyr-Chloromethylketone
CAS:Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].Formula:C24H29ClN2O5Colore e forma:SolidPeso molecolare:460.956,6′-Dihydroxythiobinupharidine
CAS:6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormula:C30H42N2O4SColore e forma:SolidPeso molecolare:526.73Z-FG-NHO-Bz
CAS:Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Formula:C26H25N3O6Colore e forma:SolidPeso molecolare:475.49LN5P45
LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis [1Formula:C13H15ClN2O2Colore e forma:SolidPeso molecolare:266.72JTE-607
CAS:JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.Formula:C25H33Cl4N3O5Purezza:97.88%Colore e forma:White SolidPeso molecolare:597.36Ref: TM-T27695
1mg42,00€5mg93,00€1mL*10mM (DMSO)109,00€10mg150,00€25mg310,00€50mg492,00€100mg707,00€200mg973,00€LY 3000328
CAS:LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.Formula:C25H29FN4O5Purezza:97.83% - 99.54%Colore e forma:White SolidPeso molecolare:484.52Ref: TM-TQ0116
1mg90,00€5mg198,00€1mL*10mM (DMSO)207,00€10mg263,00€25mg385,00€50mg557,00€100mg782,00€CA-074 methyl ester
CAS:CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). neuroprotective effect. High-Quality, Low-Cost!Formula:C19H31N3O6Purezza:97.26% - 99.58%Colore e forma:SolidPeso molecolare:397.472-Cyanopyrimidine
CAS:2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)Formula:C5H3N3Purezza:99.27%Colore e forma:SolidPeso molecolare:105.1Aloxistatin
CAS:Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.Formula:C17H30N2O5Purezza:99.46% - 99.69%Colore e forma:SolidPeso molecolare:342.43KGP94
CAS:KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.Formula:C14H12BrN3OSPurezza:99.6%Colore e forma:White SolidPeso molecolare:350.23Ref: TM-T27730
1mg65,00€5mg138,00€1mL*10mM (DMSO)152,00€10mg215,00€25mg359,00€50mg510,00€100mg692,00€200mg928,00€Balicatib
CAS:Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.Formula:C23H33N5O2Purezza:97.78% - 98.17%Colore e forma:SolidPeso molecolare:411.54E 64c
CAS:E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.Formula:C15H26N2O5Purezza:98.73%Colore e forma:SolidPeso molecolare:314.38L-006235
CAS:L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.Formula:C24H30N6O2SPurezza:99.37%Colore e forma:SolidPeso molecolare:466.6Ref: TM-T21616
2mg39,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg177,00€50mg299,00€100mg432,00€200mg602,00€MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Formula:C22H26N2O4Purezza:95.06%Colore e forma:SolidPeso molecolare:382.45Ref: TM-T2470
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)75,00€10mg90,00€25mg128,00€50mg167,00€100mg284,00€Odanacatib
CAS:Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.Formula:C25H27F4N3O3SPurezza:98.53% - 99.53%Colore e forma:SolidPeso molecolare:525.56(1S,2R)-Alicapistat
CAS:(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.Formula:C25H27N3O4Purezza:99.60%Colore e forma:White SolidPeso molecolare:433.5Ref: TM-T60150
1mg64,00€5mg142,00€1mL*10mM (DMSO)167,00€10mg197,00€25mg299,00€50mg400,00€100mg537,00€ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formula:C19H35N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:401.56S 2160
CAS:S 2160 is a synthetic chromogenic substrate for thrombin.Formula:C33H40N8O6Colore e forma:SolidPeso molecolare:644.72Cathepsin Inhibitor 1
CAS:Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.Formula:C20H24ClN5O2Purezza:99.78%Colore e forma:SolidPeso molecolare:401.89Ref: TM-T6015
1mg46,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg144,00€25mg236,00€50mg371,00€100mg522,00€200mg743,00€
