Cisteina proteasi
Gli inibitori delle proteasi a cisteina sono composti che mirano e inibiscono le proteasi a cisteina, una classe di enzimi che degradano le proteine rompendo i legami peptidici in cui un residuo di cisteina agisce come nucleofilo. Questi enzimi sono coinvolti in vari processi fisiologici, tra cui l'apoptosi, la risposta immunitaria e il turnover proteico. Gli inibitori delle proteasi a cisteina sono cruciali per lo studio di malattie come il cancro, i disturbi neurodegenerativi e le infezioni parassitarie. Presso CymitQuimica, offriamo inibitori delle proteasi a cisteina per supportare la tua ricerca in proteolisi, regolazione cellulare e scoperta di farmaci.
Trovati 117 prodotti per "Cisteina proteasi".
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BI-1915
CAS:BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.Formula:C21H37N5O3Colore e forma:SolidPeso molecolare:407.55Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Formula:C28H21F3N6OSColore e forma:SolidPeso molecolare:546.57RO5461111
CAS:RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Formula:C27H24F6N4O4SColore e forma:SolidPeso molecolare:614.56SID 26681509 quarterhydrate
SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).Formula:C27H35N5O6SColore e forma:SolidPeso molecolare:544.16Z-Val-Val-Nle-diazomethylketone
CAS:Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.Formula:C25H37N5O5Colore e forma:SolidPeso molecolare:487.59Dual Cathepsin L/JAK-IN-1
CAS:DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).Formula:C19H18ClN5Colore e forma:SolidPeso molecolare:351.833ONO-5334
CAS:ONO-5334: selective cathepsin K inhibitor, potential for osteoporosis study; Ki: 0.10 nM (human), 0.049 nM (rabbit), 0.85 nM (rat).Formula:C21H34N4O4SPurezza:98.91% - 99.97%Colore e forma:SolidPeso molecolare:438.58Cathepsin K-IN-8
CAS:CathepsinK-IN-8 (cxample 6-60) is an inhibitor of cathepsin K, which is useful for researching inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, and tumors.Formula:C25H32N6O2Peso molecolare:448.56AEP-IN-1
APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.Formula:C18H27N3O3Colore e forma:SolidPeso molecolare:333.43SAR-114137
CAS:SAR-114137 is a histone sphingomyelin kinase inhibitor used in the study of molluscum arteriosum and peripheral neuropathic pain.Formula:C25H34N4O7SPurezza:99.09% - 99.91%Colore e forma:SolidPeso molecolare:534.63Cathepsin C-IN-5
CAS:Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.Formula:C21H17ClN6OSColore e forma:SolidPeso molecolare:436.92AEP-IN-3
CAS:AEP-IN-3 (compound 18) is an orally administered, potent asparagine endopeptidase (AEP) inhibitor that effectively crosses the blood-brain barrier. It boasts an IC50 of 7.8 ± 0.9 nM and is applicable in Alzheimer's Disease (AD) research [1].Formula:C21H21F4N3O4Peso molecolare:455.4Z-FY-CHO
CAS:Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.Formula:C26H26N2O5Purezza:95.88%Colore e forma:SolidPeso molecolare:446.5GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Formula:C33H39N3O6Colore e forma:SolidPeso molecolare:573.68Verducatib
CAS:Verducatib is an inhibitor of cathepsins (cathepsin).Formula:C31H35FN4O3Colore e forma:SolidPeso molecolare:530.633MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Formula:C17H24F3N3O4Purezza:99.27%Colore e forma:White SolidPeso molecolare:391.39PD 151746
CAS:PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Formula:C11H8FNO2SPurezza:98.63% - ≥95%Colore e forma:Yellow SolidPeso molecolare:237.25
