Glutaminasi
Gli inibitori della glutaminasi sono composti che inibiscono la glutaminasi, un enzima che catalizza la conversione della glutamina in glutammato, un passaggio cruciale nel metabolismo cellulare, specialmente nelle cellule tumorali. La glutaminasi svolge un ruolo chiave nel fornire energia e precursori biosintetici per le cellule in rapida proliferazione. Gli inibitori della glutaminasi sono importanti per esplorare le dipendenze metaboliche nelle cellule tumorali e sviluppare potenziali strategie terapeutiche. Presso CymitQuimica, offriamo inibitori della glutaminasi per supportare la tua ricerca nel metabolismo del cancro, nella bioenergetica cellulare e nella scoperta di nuove terapie.
Trovati 46 prodotti di "Glutaminasi"
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BJJF078
CAS:BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.Formula:C27H29N3O6SPurezza:99.56%Colore e forma:SoildPeso molecolare:523.6LDN-27219
CAS:LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.Formula:C20H16N4O2S2Purezza:99.01% - 99.38%Colore e forma:SolidPeso molecolare:408.5Ref: TM-T11831
1mg34,00€5mg63,00€1mL*10mM (DMSO)67,00€10mg96,00€25mg152,00€50mg221,00€100mg334,00€200mg489,00€PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.Formula:C55H73N9O10SPurezza:98%Colore e forma:SolidPeso molecolare:1052.29LM11
LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.
Formula:C26H18Cl2N4O5Peso molecolare:536.06543L-Methionine-DL-sulfoximine
CAS:MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Formula:C5H12N2O3SPurezza:99.56% - ≥98%Colore e forma:White Crystalline PowderPeso molecolare:180.23Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Formula:C4H10AsNO4Peso molecolare:210.982586-Diazo-5-oxo-L-nor-Leucine
CAS:6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).Formula:C6H9N3O3Purezza:98.04% - 98.93%Colore e forma:SolidPeso molecolare:171.15Glutaminase C-IN-2
Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.Formula:C24H23N7O2SPurezza:98%Colore e forma:SolidPeso molecolare:473.55GLS1 Inhibitor-7
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, andFormula:C20H17F3N4O3S2Purezza:98%Colore e forma:SolidPeso molecolare:482.5HB-2-30
CAS:HB-2-30 is a far-red fluorescent transglutaminase 2 (TG2) probe for in vitro and in vivo endocytosis imaging. HB-2-30 complexes with TG2 and α2-macroglobulin for efficient endocytosis via the LRP1 pathway.Formula:C66H86N10O14S2Peso molecolare:1307.58PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.Formula:C47H57N9O6SPurezza:98%Colore e forma:SolidPeso molecolare:876.08Glutaminase-IN-1
CAS:Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.Formula:C26H24F3N7O3SePurezza:98.65% - 98.65%Colore e forma:SolidPeso molecolare:618.47Glutaminase-IN-3
CAS:Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.Formula:C19H19F3N6O2SPurezza:98.51%Colore e forma:SolidPeso molecolare:452.45Telaglenastat
CAS:Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.Formula:C26H24F3N7O3SPurezza:97.57% - 99.89%Colore e forma:SolidPeso molecolare:571.57L-Albizziin
CAS:L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.Formula:C4H9N3O3Purezza:99.98%Colore e forma:White PowderPeso molecolare:147.13Glutaminase C-IN-1
CAS:Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.Formula:C27H27BrN2OPurezza:99.68% - >99.99%Colore e forma:SolidPeso molecolare:475.42Ref: TM-T3964
2mg42,00€5mg60,00€1mL*10mM (DMSO)67,00€10mg87,00€25mg162,00€50mg273,00€100mg378,00€200mg557,00€GK921
CAS:GK921 is a transglutaminase 2 (TGase) inhibitor.Formula:C21H20N4OPurezza:97.44% - 99.92%Colore e forma:SolidPeso molecolare:344.41BPTES
CAS:BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.Formula:C24H24N6O2S3Purezza:95.83% - 99.64%Colore e forma:SolidPeso molecolare:524.68Ref: TM-T6791
1mg34,00€2mg49,00€5mg65,00€10mg84,00€1mL*10mM (DMSO)84,00€25mg142,00€50mg207,00€100mg308,00€200mg447,00€500mg732,00€Zampilimab
CAS:Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.Purezza:95%Colore e forma:LiquidPeso molecolare:~150 kDaIrbesartan-d4
CAS:Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.Formula:C25H28N6OPurezza:>99.99%Colore e forma:SolidPeso molecolare:432.55
